A5039532569- Dialysis and Renal Disease Management
- Peripheral Nerve Disorders
- Peripheral Neuropathies and Disorders
- Amyotrophic Lateral Sclerosis Research
- Botulinum Toxin and Related Neurological Disorders
- Chronic Disease Management Strategies
- Orthopedic Surgery and Rehabilitation
- Neurogenetic and Muscular Disorders Research
- Heart Failure Treatment and Management
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Healthcare Systems and Reforms
- Systemic Lupus Erythematosus Research
- Cardiac Imaging and Diagnostics
- Nerve injury and regeneration
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Gestational Diabetes Research and Management
- Streptococcal Infections and Treatments
- Pain Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Trigeminal Neuralgia and Treatments
- Hereditary Neurological Disorders
- GDF15 and Related Biomarkers
- Infections and bacterial resistance
Jilin University
2023-2025
Peking University
2017-2023
Peking University First Hospital
2017-2023
University of Science and Technology Beijing
2023
Renmin Hospital of Wuhan University
2011-2022
Wuhan University
2011-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Yixing People's Hospital
2017
Jiangsu University
2017
Ministry of Education of the People's Republic of China
2017
Abstract Streptococcus suis ( S. ) is an emerging zoonotic pathogen that threatens both animal and human health worldwide. UgpE a protein subunit of the Ugp (uptake g lycerol p hosphate) transporter system involved in glycerophospholipid synthesis bacterial membranes. In this study, ugpE deletion mutant was constructed effects on cell morphology, biofilm formation, virulence were investigated. Deletion slowed down growth impaired chain formation capsular by downregulating mRNA levels regulon...
Abstract Background Patients receiving maintenance hemodialysis (HD) and peritoneal dialysis (PD) are frequently hospitalized. Reducing unplanned 30-day hospital readmissions is a key priority for improving the quality of health care. The purpose this study was to assess association between Charlson Comorbidity Index (CCI), which has been used evaluate multi-comorbidities status, readmission in patients on HD PD therapy. Methods Hospital Quality Monitoring System (HQMS), national...
Objective: Studies have demonstrated the protective effects of biomaterials against myocardial infarction (MI), but relationship between their physical characteristics and function is incompletely understood. This study investigated such relationships for a hydrogel preparation. Methods: Two types poly(N-isopropylacrylamide) (PNIPAAm) with different degradation times (Gel A Gel B) were synthesized. In vivo formation maintenance observed confirmed in mice. The solutions also injected into...
Abstract Previous studies suggested that the reactive hyperemia index (RHI) is a promising cardiovascular risk predictor. We aimed to evaluate clinical determinants of RHI and its association with circulating endothelial injury cardiac markers in hemodialysis patients. Among 368 patients recruited, was evaluated by peripheral arterial tonometry (PAT) on midweek nondialysis day. Clinical were explored multiple stepwise regression analysis associations between general linear models. The major...
[Purpose] To clarify the features associated with decrements in compound muscle action potentials (CMAP) during slow-rate repetitive nerve stimulation (RNS) of muscles involved amyotrophic lateral sclerosis (ALS) mainland China. [Subjects and Methods] A retrospective study decremental responses to RNS was performed compare patients ALS those myasthenia gravis (MG). [Results] significant decrement (>5%) observed at least one 54% patients. The trapezius most commonly affected (67%). In group,...
Objective Genetic variants in FH (complement factor H) were reported to associate with susceptibility systemic lupus erythematosus (SLE). This study proposed that the genetic defects of and development nephritis might be different. Methods enrolled 334 patients, 269 SLE patients without clinical renal involvement 350 controls. Two-step genotyping was performed. First, all exons gene fully sequenced 100 healthy Second, three common functional, rs1061170, rs800292 rs6677604, conducted...
The hospital admission rate is high in patients treated with peritoneal dialysis (PD), and the length of stay (LOS) a key indicator medical resource allocation. This study aimed to develop scoring tool for predicting prolonged LOS (pLOS) PD by combining machine learning traditional logistic regression (LR).This was based on patient data collected using Hospital Quality Monitoring System (HQMS) China. Three methods, classification tree (CART), random forest (RF), gradient boosting decision...
Background The increasing number of patients treated with peritoneal dialysis (PD) and their consistently high rate hospital admissions have placed a large burden on the health care system. Early clinical interventions optimal management at risk prolonged length stay (pLOS) may help improve medical efficiency prognosis PD-treated patients. If timely are not provided, pLOS face poor expenses, which will also be hospitals. Therefore, physicians need an effective prediction model for Objective...
Objectives: To assess prospectively the significance of sonographic measurements median nerve in diagnosis carpal tunnel syndrome (CTS), to look for proper parameters and cutoff values diagnosis, correlate with electrophysiological findings. Materials methods: This study involved 30 patients, who were clinically diagnosed as CTS merely based on their symptoms signs; healthy volunteers served controls. Eligible subjects underwent electromyographic detection. Results: In patient group,...
Objective: Acute bulbar palsy plus (ABPp) syndrome is a rare regional variant of Guillain-Barré (GBS) characterized by acute combined with other cranial symptoms or ataxia without limb and neck weakness. We aim to investigate characteristics ABPp analyze its nosological position within the GBS spectrum. Methods: A patient was reported, previous case reports patients who met criteria for from literature were reviewed. Results: total 28 included in our study. Median age 32 years. Most (78.6%)...
Objective: To identify the characteristics of repetitive nerve stimulation (RNS) in patients with amyotrophic lateral sclerosis (ALS), and further verify electrophysiological exclusion criteria ALS. Methods: A total 150 ALS who were admitted to Department Neurology Renmin Hospital Wuhan University from January 2015 December 2018 enrolled. Clinical data enrolled collected. The differences amplitudes compound muscle action potential (CMAP) between trapezius (Trap) abductor digiti minimi (ADM)...
[Purpose] To prospectively assess the effectiveness of neutral wrist nocturnal splinting in patients with carpal tunnel syndrome (CTS) by using clinical scores and nerve conduction studies (NCS). [Subjects Methods] Forty-one enrolled study were clinically evaluated a symptom severity scale (SSS) functional status (FSS), electrophysiologically conventional NCS; distal motor latency (DML), sensory velocity (SCV), difference between median ulnar nerves (ΔDSL) measured. Subjects treated...
Objective To investigate the diagnostic significance of sensory nerve action protential (SNAP) on diabetic neuropathy (DN), through measuring amplitude and ratio. Methods There were 91 patients with type 2 diabetes involing 51 cases without neurologic symptom/sign as subgroup Ⅰ, 30 mild Ⅱ 10 severe Ⅲ, according to Toronto clinical scoring system (TCSS). Thirty-nine healthy volunteers age- gender-matched served controls. SNAP antidromically recorded using surface electrodes. The observed...
Background: Previous studies have shown cardiovascular disease (CVD) to be a risk factor in the prediction of 30-day hospital readmission among patients receiving dialysis. However, Asian populations are limited. In present study, we examined association between CVD and Chinese maintenance dialysis.Methods: Patients dialysis were identified by searching national claims database, China Health Insurance Research Association (CHIRA) using International Classification Diseases revision 10...
High-quality vaccine-preventable disease (VPD) surveillance data are critical for timely outbreak detection and response. In 2019, the World Health Organization (WHO) African Regional Office (AFRO) began transitioning from Epi Info, a free, CDC-developed statistical software package with limited capability to integrate other information systems, affecting reporting timeliness use, District Information Software 2 (DHIS2). DHIS2 is free open-source platform electronic aggregate Integrated...
Streptococcus suis (S. suis) is an emerging zoonotic pathogen that threatens both animal and human health worldwide. UgpE a protein subunit of the Ugp (uptake glycerol phosphate) transporter system involved in glycerophospholipid synthesis bacterial membranes. In this study, ugpE deletion mutant was constructed effects on cell morphology, biofilm formation, virulence were investigated. Deletion did not affect growth but impaired chain formation capsular by downregulating mRNA levels regulon...