A5039725604- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Thyroid Cancer Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Multiple Myeloma Research and Treatments
- Wnt/β-catenin signaling in development and cancer
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Thyroid Disorders and Treatments
- DNA Repair Mechanisms
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Genomics and Chromatin Dynamics
- HER2/EGFR in Cancer Research
- Ubiquitin and proteasome pathways
University of Chieti-Pescara
2019-2024
Institute of Oncology Research
2018-2021
Università della Svizzera italiana
2018
Colorectal cancer (CRC) is a multistep process that arises in the colic tissue microenvironment. Oxidative stress plays role mediating CRC cell survival and progression, as well promoting resistance to therapies. progression associated with Wnt/β-Catenin signaling dysregulation loss of proper APC functions. Cancer recurrence/relapse has been attributed altered ROS levels, produced cancerous The effect oxidative distress on light functions unclear. This study evaluated H2O2-induced short-term...
Background: Colorectal adenoma undergoes neoplastic progression via the normal epithelium-adenoma-adenocarcinoma sequence as reported in Vogelgram. The risk of developing cancer is strongly associated with number and size subtype. Currently, adenomatous polyps can be distinguished on basis histology: prevalence are tubular, 5-15% villous tubular/villous. Considering increased for malignant transformation described tubular/villous adenomas, patients diagnosed polyposis at CRC. Wnt/β-catenin...
Thyroid diseases have a complex and multifactorial aetiology. Despite the numerous studies on signals referable to malignant transition, molecular mechanisms concerning role of oxidative stress remain elusive. Based its strong power, H2O2 could be responsible for high level DNA damage observed in cancerous thyroid tissue hyperactivation mitogen-activated protein kinase (MAPK) PI3K/Akt, which mediate ErbB signaling. Increased levels 8-oxoG adducts been detected early stages cancer. These...
Gastric cancer is worldwide the fifth and third for incidence mortality, respectively. Stomach wall daily exposed to oxidative stress BER system has a key role in defense from oxidation-induced DNA damage, whilst ErbB receptors have important roles pathogenesis of cancer. We used AGS cells as an aggressive gastric carcinoma cell model, treated with H2O2 alone or combined signaling pathway inhibitors, evaluate effects cancer, focusing on modulation pathways their eventual cross-talk system....
The aetiology of breast and ovarian cancer (BC/OC) is multi‑factorial. At present, the involvement base excision repair (BER) glycosylases (MUTYH OGG1) in BC/OC predisposition controversial. present study investigated whether germline mutation status mRNA expression two BER genes, <em>MUTHY</em> <em>OGG1</em>, were correlated with <em>BRCA1</em> 59 patients 50 matched population controls. In addition, to evaluate relationship between <em>MUTYH</em>, <em>OGG1</em> <em>BRCA1</em>, their...
The role of non-genetic factors as modifiers TP53-related hereditary breast cancer (BC) risk is debated. In this regard, little known about the impact germline TP53 mutations on BC in sub-Saharan Africa, where disease often presents non-contraceptive multiparous premenopausal women with extended history breastfeeding. Herein, we report found a series 92 Sudanese patients characterized for reproductive history.
Abstract Background: Bromodomain and Extra-Terminal domain (BET) proteins are epigenetic readers that play a fundamental role in transcription regulation. Preclinical early clinical evidences sustain BET targeting as promising novel approach for cancer treatment. degraders chimeric compounds merging inhibitor, which allows the binding to bromodomains, linked an additional small molecule, mediates E3 ubiquitin ligase complex, triggering degradation via proteasome. These based on concept of...
Aim: Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that play a fundamental role in transcription regulation. Preclinical early clinical evidence sustain BET targeting as an anti-cancer approach. degraders chimeric compounds comprising of inhibitor, which allows the binding to bromodomains, linked small molecule, binder for E3 ubiquitin ligase complex, triggering degradation via proteasome. These degraders, called proteolysis-targeting chimeras (PROTACs), can...
The colorectal adenoma undergoes neoplastic progression via the normal epithelium-adenoma-adenocarcinoma sequence as reported in Vogelgram. hazard of developing a tumor is deeply associated with number and size adenomas their subtype. Adenomatous polyps are histologically categorized follows: approximately 80-90% tubular, 5-15% villous, 5-10% tubular/villous. Given higher risk malignant transformation observed tubular/villous adenomas, patients diagnosed adenomatous polyposis at an improved...