A5062912484- Rabies epidemiology and control
- Virology and Viral Diseases
- Poxvirus research and outbreaks
- Microbial infections and disease research
- Bacillus and Francisella bacterial research
- Bat Biology and Ecology Studies
- Yersinia bacterium, plague, ectoparasites research
- Data-Driven Disease Surveillance
- Genomics and Phylogenetic Studies
- Viral Infections and Vectors
- Venomous Animal Envenomation and Studies
- Viral Infections and Outbreaks Research
- Human-Animal Interaction Studies
- Zoonotic diseases and public health
Ifakara Health Institute
2022-2024
University of Nairobi
2020-2024
University of Glasgow
2020-2024
Tanzania Industrial Research and Development Organization
2021-2024
Glasgow Centre for Population Health
2021-2024
University of Embu
2024
Kenya Medical Research Institute
2024
Eisenhower Medical Center
2024
National Institutes of Health
2024
Uniformed Services University of the Health Sciences
2024
Points• Surveillance is critical to manage preventative health services and control infectious diseases.Integrated surveillance involving public health, veterinary, environmental sectors urgently needed effectively zoonoses vector-borne diseases.However, most in low-income countries paper-based, provides negligible timely feedback, poorly incentivised, results delays, limited reporting, inaccurate data, costly processing.• The potential of mobile technologies for improving system has been...
A rabies elimination demonstration project was implemented in Tanzania from 2010 through to 2015, bringing together government ministries the health and veterinary sectors, World Health Organization (WHO), national international research institutions. Detailed data on mass dog vaccination campaigns, bite exposures, use of post-exposure prophylaxis (PEP) human deaths were collected throughout duration areas. Despite no previous experience within areas, district officers able implement...
Almost half of all countries in the world are effectively free human deaths from dog-mediated rabies. But disease still affects people low- and middle-income countries, especially rural poor, children. Successful regional elimination rabies is attributable to advances significant sustained investment dog vaccination, post-exposure vaccination surveillance, illustrated by productive efforts reduce Latin America over last 35 years. Nonetheless, facing endemic face barriers elimination. Using...
<ns4:p>Genomic surveillance is an important aspect of contemporary disease management but has yet to be used routinely monitor endemic transmission and control in low- middle-income countries. Rabies almost invariably fatal viral that causes a large public health economic burden Asia Africa, despite being entirely vaccine preventable. With policy efforts now directed towards achieving global goal zero dog-mediated human rabies deaths by 2030, establishing effective tools critical. Genomic...
Dog-mediated rabies is endemic across Africa causing thousands of human deaths annually. A One Health approach to advocated, comprising emergency post-exposure vaccination bite victims and mass dog break the transmission cycle. However, impacts cost-effectiveness these components are difficult disentangle. We combined contact tracing with whole-genome sequencing track in animal reservoir spillover risk humans from 2010 2020, investigating how a reduced disease burden eliminated Pemba Island,...
Genomic surveillance is an important aspect of contemporary disease management but has yet to be used routinely monitor endemic transmission and control in low- middle-income countries. Rabies almost invariably fatal viral that causes a large public health economic burden Asia Africa, despite being entirely vaccine preventable. With policy efforts now directed towards achieving global goal zero dog-mediated human rabies deaths by 2030, establishing effective tools critical. data can provide...
Abstract Rabies, a viral disease that causes lethal encephalitis, kills ≈59,000 persons worldwide annually, despite availability of effective countermeasures. Rabies is endemic in Kenya and mainly transmitted to humans through bites from rabid domestic dogs. We analyzed 164 brain stems collected animals western eastern evaluated the phylogenetic relationships rabies virus (RABV) 2 regions. also RABV genomes for potential amino acid changes vaccine antigenic sites nucleoprotein glycoprotein...
Genomic data can be used to track the transmission and geographic spread of infectious diseases. However, sequencing capacity required for genomic surveillance remains limited in many low- middle-income countries (LMICs), where dog-mediated rabies and/or transmitted by wildlife such as vampire bats pose major public health economic concerns. We present here a rapid affordable sample-to-sequence-to-interpretation workflow using nanopore technology. Protocols sample collection diagnosis are...
<title>Abstract</title> <bold>Background: </bold>Rabies remains a major public health problem in low- and middle-income countries. However, human rabies deaths are rarely laboratory-confirmed, especially Africa. Here, we use virus sequence data to enhance investigations for series of 5 East Africa discuss the implications these at individual, healthcare, societal-level. <bold>Case presentation: </bold>The epidemiological context care cases is contrasting: three bite victims did not receive...
The molecular clock hypothesis assumes that mutations accumulate on an organism's genome at a constant rate over time, but this assumption does not always hold true. While modelling approaches exist to accommodate deviations from strict clock, assumptions about variation may fully represent the underlying evolutionary processes. There is considerable variability in rabies virus (RABV) incubation periods, ranging days year, during which viral replication be reduced. This prompts question of...
Abstract The molecular clock hypothesis assumes that mutations accumulate on an organism’s genome at a constant rate over time, but this assumption does not always hold true. While modelling approaches exist to accommodate deviations from strict clock, assumptions about variation may fully represent the underlying evolutionary processes. There is considerable variability in rabies virus (RABV) incubation periods, ranging days year, during which viral replication be reduced. This prompts...
Abstract Background Dog-mediated rabies is endemic across Africa causing thousands of human deaths annually. A One Health approach to advocated, comprising emergency post-exposure vaccination bite victims and mass dog break the transmission cycle. However, impacts cost-effectiveness these components are difficult disentangle. Methods We combined contact tracing with whole-genome sequencing track in animal reservoir spillover risk humans from 2010-2020, investigating how a reduced disease...
Background: Dog-mediated rabies is endemic across Africa causing thousands of deaths annually. We investigated how components a One Health approach, post-exposure vaccination bite victims and dog vaccination, reduced the disease burden eliminated from Pemba island, Tanzania.Methods: From 2010-2020 we conducted islandwide contact tracing animal cases, human exposures whole-genome sequencing sampled viruses. With resulting data inferred transmission chains, estimated case detection quantified...