A5067620514- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
- HIV-related health complications and treatments
- Ultrasound Imaging and Elastography
- Ultrasound and Hyperthermia Applications
- Parasitic infections in humans and animals
- Viral gastroenteritis research and epidemiology
- COVID-19 Impact on Reproduction
- Pancreatitis Pathology and Treatment
- HIV Research and Treatment
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Congenital Anomalies and Fetal Surgery
- SARS-CoV-2 and COVID-19 Research
University of Pavia
2010-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2005-2024
Policlinico San Matteo Fondazione
2006-2024
University of Atlanta
2021
University of South Carolina
2021
Thomas Jefferson University
2021
Texas Children's Hospital
2021
Baylor College of Medicine
2021
University of Alabama at Birmingham
2021
Northeast Ohio Medical University
2021
OBJECTIVES: The primary aim of this study was to investigate the value attenuation imaging (ATI), a novel ultrasound technique for detection steatosis, by comparing results that obtained with controlled parameter (CAP) and using MRI-derived proton density fat fraction (PDFF) as reference standard. METHODS: From March November 2018, 114 consecutive adult subjects potentially at risk steatosis 15 healthy controls were enrolled. Each subject underwent ATI CAP assessment on same day. MRI-PDFF...
Objectives The main aim was to assess the performance and cutoff value for detection of liver steatosis (grade S > 0) with Attenuation Imaging–Penetration (ATI‐Pen) algorithm available on Aplio i‐series ultrasound systems (Canon Medical Systems, Otawara, Japan). magnetic resonance imaging–derived proton density fat fraction (MRI‐PDFF) used as reference standard. Secondary aims were compare results those obtained previous ATI (Attenuation Imaging–General [ATI‐Gen]) controlled attenuation...
Objectives The primary aim was to estimate the influence of various depths on ultrasound attenuation coefficient (AC) multiple vendors in liver. secondary evaluate impact region interest (ROI) size AC measurements a subset participants. Methods This Institutional Review Board (IRB)‐approved Health Insurance Portability and Accountability Act (HIPAA)‐compliant retrospective study carried out two centers using AC‐Canon AC‐Philips algorithms extracting AC‐Siemens values from ultrasound‐derived...
The primary aim of this study was to determine the inter-system variability liver stiffness measurements (LSMs) in patients with varying degrees stiffness. secondary inter-observer measurements. 21 individuals affected by chronic hepatitis C and 5 healthy were prospectively enrolled. assessment LSMs performed using six ultrasound (US) systems, four which point shear wave elastography (p-SWE) two 2 D (2D-SWE) systems. Fibroscan (Echosens, France) used as reference standard. Four observers...
To assess the clinical validity of controlled attenuation parameter (CAP) in diagnosis hepatic steatosis a series overweight or obese children by using imperfect gold standard methodology. Consecutive referred to our institution for auxological evaluation obesity minor elective surgery were prospectively enrolled. Anthropometric and biochemical parameters recorded. Ultrasound (US) assessment was carried out ultrasound systems. CAP obtained with FibroScan 502 Touch device (Echosens, Paris,...
The two available pegylated interferon formulations, peginterferon alpha-2a and alpha-2b, have different pharmacokinetic profiles; as a result they may differing abilities to suppress the hepatitis C virus. A recently reported study by Formann colleagues assessing early viral kinetics among 20 patients receiving alpha-2b either once or twice weekly suggests that once-weekly administration of is not sufficient for continuous exposure over 160 h. Twice-weekly recommended avoid increases in...
Performance of Real-Time Strain Elastography, Transient and Aspartate-to-Platelet Ratio Index in the Assessment Fibrosis Chronic Hepatitis CGiovanna Ferraioli1, Carmine Tinelli2, Antonello Malfitano3, Barbara Dal Bello4, Gaetano Filice3, Carlo Filice1, Liver Study Group, Elisabetta Above1, Giorgio Barbarini3, Enrico Brunetti1, Willy Calderon3, Marta Di Gregorio1, Raffaella Lissandrin1, Serena Ludovisi3, Laura Maiocchi3, Giuseppe Michelone3, Mario Mondelli3, Savino F. A. Patruno3, Alessandro...
The hyperinflammation phase of severe SARS-CoV-2 is characterised by complete blood count alterations. In this context, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) can be used as prognostic factors. We studied NLR PLR trends at different timepoints computed optimal cutoffs to predict four outcomes: use continuous positive airways pressure (CPAP), intensive care unit (ICU) admission, invasive ventilation death. retrospectively included all adult patients with...
To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used a recently published meta-analysis.This was single center cross-sectional study. Consecutive chronic viral hepatitis scheduled for biopsy at the outpatient ward Infectious Diseases Department were enrolled. TE carried out using FibroScan™ (Echosens, Paris, France). Liver performed on same day as TE, case procedure. Fibrosis staged according to Metavir scoring...
Background & Aims: Noninvasive assessment of liver stiffness has been increasingly used to evaluate fibrosis instead biopsy, especially in patients with chronic viral hepatitis. The aim this study was assess the performance staging updated ElastPQ® technique (EPIQ7 ultrasound system, Philips Healthcare, Bothell, WA, USA) “real life” setting by using FibroScan as reference standard and understand whether use quality criteria improves technique.
 Methods: This a cross-sectional study:...
Objectives: To assess performance and cutoffs of the 2-dimensional shear wave elastography technique available on Aplio i800 ultrasound system (Canon Medical Systems, Japan), using transient as reference standard, to correlation shear-wave-speed dispersion with liver fibrosis or steatosis. Methods: This was a single-center cross-sectional study. The correlations between values obtained 2-dimensional-shear elastography, steatosis, were assessed Pearson’s r . diagnostic for staging significant...
IntroductionThere is ongoing debate regarding the role of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in asthma exacerbation, and its long-term impact on lung function individuals with asthma. In contrast, potential coronavirus disease 2019 (COVID-19) vaccination entirely unexplored.Case studyThis study examined a challenging case exacerbation 28-year-old female following two doses mRNA-based vaccine BNT162b2 (Pfizer-BioNTech) at IRCCS Policlinico San Matteo Pavia,...
Abstract An accurate prediction of the clinical outcomes European patients requiring hospitalisation for Coronavirus Disease 2019 (COVID-19) is lacking. The aim study to identify predictors in-hospital mortality and discharge in a cohort Lombardy with COVID-19. All consecutive hospitalised from February 21st March 30th, 2020, confirmed COVID-19 IRCCS Policlinico San Matteo, Pavia, Lombardy, Italy, were included. In-hospital evaluated by competing risk analysis. Fine Gray model was fitted...
Abstract Background Since nonalcoholic fatty liver disease (NAFLD) has become the leading cause of in Western world, clinicians need reliable noninvasive tools for identification NAFLD-associated fibrosis. Limited evidence on performance novel shear wave elastography technique Elast-PQ (EPQ) NAFLD is available. Method In this prospective, European multinational study we assessed diagnostic accuracy EPQ using vibration-controlled transient (VCTE) as a reference standard. Results Among 353...
Summary Background Peginterferon alfa‐2a and alfa‐2b, the two commercially available pegylated interferons, have different pharmacokinetic properties that produce differing abilities to suppress replication of hepatitis C virus. Aim To compare pharmacodynamics peginterferon alfa‐2b in interferon‐naive patients with chronic C. Methods Patients were randomized receive alfa‐2a, 180 μg ( n = 10) or 1.0 μg/kg 12) once weekly. The enzymatic activity 2′5′‐oligoadenylate synthetase levels neopterin...
Background: The natural history of initially compensated cirrhosis in patients with HIV and concurrent hepatitis B virus (HBV) and/or C (HCV) infection is poorly defined. This study was designed to investigate the incidence type liver-related complications mortality coinfected cirrhotic patients. Methods: We retrospectively identified a cohort HCV or HBV viral cirrhosis. Time decompensation from causes were recorded. Results: Between 1999 2004, 392 HIV-infected underwent follow-up ≥6 months....
Ultrasound is the imaging modality most widely utilized in general population for diagnostic purposes. Controlled attenuation parameter a novel noninvasive method assessing steatosis. Our aim was to investigate whether clinical value of controlled patients referred abdominal ultrasound examinations affected by liver fibrosis.Consecutive were enrolled. and stiffness assessed with FibroScan (Echosens, France). Liver fibrosis staged according published cutoffs measurements. Pearson's or...
Background: The primary aim of our study was to assess the correlation between an improved version attenuation coefficient available on Arietta 850 ultrasound system (iATT, Fujifilm Healthcare, Tokyo, Japan) and controlled parameter (CAP). secondary whether focusing only iATT acquisition without following strict protocol for liver stiffness measurements would affect measurement. Methods: Consecutive individuals were enrolled. Pearson’s r used test ATT CAP values. concordance tested using...