A5069016864- Dialysis and Renal Disease Management
- Dermatology and Skin Diseases
- Nutrition and Health in Aging
- Libraries, Manuscripts, and Books
- Urticaria and Related Conditions
- Central Venous Catheters and Hemodialysis
- Mechanical Behavior of Composites
- COVID-19 Clinical Research Studies
- Advanced Breast Cancer Therapies
- Body Composition Measurement Techniques
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Clinical Nutrition and Gastroenterology
- Muscle and Compartmental Disorders
- COVID-19 and healthcare impacts
- Advanced Surface Polishing Techniques
- Psoriasis: Treatment and Pathogenesis
- Renal function and acid-base balance
- Ethics and bioethics in healthcare
- Asthma and respiratory diseases
- Nursing care and research
- Pancreatitis Pathology and Treatment
- Potassium and Related Disorders
- Chronic Kidney Disease and Diabetes
- Long-Term Effects of COVID-19
Hospital Universitario La Paz
2016-2025
Hospital General Universitario de Alicante Doctor Balmis
1991-2024
Acerinox (Spain)
1998-2024
Sociedad Española de Nefrología
2023-2024
Instituto Nacional de Rehabilitación
2024
Institut Català d'Oncologia
2015-2023
GEICAM – Spanish Breast Cancer Group
2022-2023
Hospital Universitari Joan XXIII de Tarragona
2008-2022
Hospital de Sant Joan Despí Moisès Broggi
2018-2022
Hospital Universitario Infanta Leonor
2022
1009 Background: Trastuzumab deruxtecan (T-DXd) is approved for adult patients (pts) with HER2+ advanced/metastatic breast cancer (mBC) who received a prior anti-HER2–based regimen. DESTINY-Breast07 Phase 1b/2 multicenter, open-label, modular study exploring the safety, tolerability, and antitumor activity of T-DXd alone or in combination other anticancer agents (NCT04538742). These results are from an interim analysis dose-expansion phase assessing ± pertuzumab (P) as first-line (1L)...
Background. Depending on the cytokine microenvironment, macrophages (Mφ) can adopt a proinflammatory (M1) or profibrotic (M2) phenotype characterized by expression of cell surface proteins such as CD206 and CD163 soluble factors CC chemokine ligand 18 (CCL18). A key role for Mφ in fibrosis has been observed diverse organ settings. We studied population human model peritoneal dialysis which continuous stress due to fluids recurrent peritonitis represent risk membrane dysfunction reflected...
Background. Peritoneal membrane deterioration during peritoneal dialysis (PD) is associated with epithelial-to-mesenchymal transition (EMT) of mesothelial cells (MC), which believed to be mainly due glucose degradation products (GDPs) present in PD solutions. Here we investigate the impact GDPs solutions on EMT MC vitro and ex vivo.
Chronic kidney disease-associated pruritus (CKD-aP), a persistent itching sensation, is prevalent among hemodialysis patients. This study aims to understand its prevalence, possible association with selected solutes, and impact on quality of life (QoL) in Involving 434 patients Spain, this observational employed survey based validated assessment tools, alongside demographic, clinical, biochemical data collection. The used statistical analyses examine the correlation between CKD-aP various...
Patients with Stage 5 chronic kidney disease who are on hemodialysis (HD) remain in a inflammatory state, characterized by the accumulation of uremic toxins that induce endothelial damage and cardiovascular (CVD). Our aim was to examine microvesicles (MVs), monocyte subpopulations, angiopoietins (Ang) identify prognostic markers HD patients or without diabetes mellitus (DM). A total 160 prevalent from 10 centers across Spain were obtained Biobank Nephrology Renal Network (Madrid, Spain): 80...
Kidney replacement therapy (KRT) confers the highest risk of death from coronavirus disease 2019 (COVID-19). However, most data refer to early pandemic waves. Whole-year analysis compared with prior secular trends are scarce.We present 2020 REMER Madrid KRT registry, corresponding Spanish Region hardest hit by COVID-19.In 2020, incidence decreased 12% versus 2019, while prevalence 1.75% for first time since records began and number kidney transplants (KTs) 16%. Mortality on was 10.2% (34%...
The guarantee of surface integrity has become a primary objective for researchers when analysing the reliability machined aircraft aluminium alloy structural parts in high-speed machining. This work studies effect cutting speed on face milled 7050-T7451 workpieces. First, workpieces were under dry conditions using three speeds (200, 800, 1400 m/min) at constant feed (0.20 mm/tooth) and depth cut (1 mm). An indexable milling cutter with diameter 50 mm five uncoated inserts was used tests....
Background. Patients starting peritoneal dialysis (PD) with active cardiovascular disease (CVD) show higher protein and albumin levels in effluent. Peripheral arterial (PAD) is increasingly recognized as an entity particularly associated mortality. Methods. To explore whether daily clearance (PrC) on PD a risk marker, we have formulated the hypothesis that PAD, expression of highest CVD grade, specifically related to amount PrC. Results. The average 24-h effluent losses (PPL) was 6.88 ± 3.31...
<b><i>Background/Aims:</i></b> A recent alert from Spanish health authorities warned of a higher incidence reported hypersensitivity reactions to hemodialysis membranes with polysulfone, in the 2017 review acute dialyzers found only published reports 21<sup>st</sup> century on polysulfone and its derivatives. The aim is assess/evaluate current characteristics patients. <b><i>Methods:</i></b> retrospective multicentre study 9...
Uremic pruritus (UP) is one of the most uncomfortable symptoms for patients in dialysis. UP has a great impact on dialysis patients' quality life and prevalence between those (28–70%). Physiopathology unknown usually unnoticed nephrologists (in more than 65% centers underdiagnosed). This lack awareness drives to unsuccessful treatment this symptom. Moreover, fact that studies have been carried out small populations difficulty assessing complicates correct therapeutical approach. For reason,...
The treatment of cirrhotic patients with ascites and end-stage renal disease is complex, due mainly to decreased effective arterial volume hemodynamic instability. Peritoneal dialysis as a continuous therapy represents an alternative hemodialysis-related intolerance. We report on our experience that others treated by peritoneal dialysis. Hemodynamic tolerance was excellent in all solute water transport increased above the normal range almost cases. Morbidity mortality were related...
Our aim was to evaluate the prognostic value of 2 measurements serum adiponectin levels for all-cause mortality and cardiovascular (CV) in uremic patients.We analyzed 184 patients (19-86 years) undergoing peritoneal dialysis (n = 86) or hemodialysis 98). All had (at baseline after 1 year). Relationships between were studied by means survival analysis Cox regression analysis.During a median follow-up time 31.2 months, 67 (36.4%) died, 26 (14.1%) as result CV disease. Mean with 1-year values...
Advanced oxidation protein products (AOPPs) are considered as markers and even mediators of the proinflammatory effect oxidative stress in uremia. We hypothesized that an increase associated with peritoneal dialysis (PD), estimated by variation plasma AOPPs over time, might be cardiovascular (CV) risk overall prognosis. In 48 PD patients, blood samples were collected on two occasions: first one six months after starting therapy second one, year after. The level was significantly CV...
El prurito asociado a la enfermedad renal crónica (Pa-ERC) es una de las comorbilidades más comunes e incapacitantes en los pacientes con ERC avanzada. Además, está un mayor riesgo mortalidad, peor calidad vida, aparición trastornos del sueño, alteraciones salud mental y uso recursos sanitarios. La presentación clínica Pa-ERC muy heterogénea, lo que dificulta su diagnóstico tratamiento. Actualmente, no existen guías nivel nacional sobre el manejo Pa-ERC. objetivo este documento proporcionar...
Several cases of patients with anaphylactic or systemic hypersensitivity reactions to polysulfone (PS) hemodialysis (HD) membranes and tolerance cellulose triacetate (CTA) have recently been reported. To investigate the mechanisms involved in PS hypersensitivity, basophil, T cell, complement activation were analyzed acute-phase samples from two PS-based membranes. Basophil cell activation, as well higher serum tryptase levels detected compared basal levels. Complement (C3 C4) decreased...
Abstract Background: Detectable troponin below the 99th percentile may reflect an underlying cardiac abnormality which might entail prognostic consequences. This study aimed to investigate prognosis of patients admitted emergency department (ED) with detectable reference limit who did not present acute coronary syndrome (ACS). Methods: We analysed clinical data all consecutive ED during years 2012 and 2013 in whom was requested by attending clinician (cTnI Ultra Siemens, Advia Centaur)....