A5011392242- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects and Toxicity Studies
- Muscle and Compartmental Disorders
- Gout, Hyperuricemia, Uric Acid
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Diseases and Glomerulopathies
- Potassium and Related Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal and related cancers
- Systemic Lupus Erythematosus Research
- Case Reports on Hematomas
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Acute Kidney Injury Research
- Vasculitis and related conditions
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Central Venous Catheters and Hemodialysis
- Neurological and metabolic disorders
- Abdominal vascular conditions and treatments
- COVID-19 Clinical Research Studies
- Ion Transport and Channel Regulation
- Medicine and Dermatology Studies History
- Erythropoietin and Anemia Treatment
Hospital Universitario Fundación Jiménez Díaz
2016-2024
Universidad Autónoma de Madrid
2016-2024
Instituto de Salud Carlos III
2019-2021
Fundación Renal
2017-2021
Spanish Clinical Research Network
2016-2020
Federación Española de Enfermedades Raras
2020
Chronic kidney disease (CKD) expands the prior concept of chronic renal insufficiency by including patients with relatively preserved function, as assessed estimated glomerular filtration rate (eGFR), even these early CKD stages are associated an increased risk for all-cause death and cardiovascular death, progression acute injury. A decreased eGFR (<60 mL/min/1.73 m2) is itself diagnostic when persisting >3 months. However, ≥60 m2, additional criterion required to diagnose CKD. In a recent...
In April 2019, two major Phase 3 randomized clinical trials were published that assessed primary renal outcomes in diabetic kidney disease (DKD) type 2 diabetes mellitus (T2DM). The Canagliflozin and Renal Events Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) tested an already available antidiabetic drug, canagliflozin, the Study of Diabetic Atrasentan (SONAR) a novel molecule, endothelin-1 receptor blocker atrasentan, both on top renin-angiotensin system blockade. Both...
In 2018, World Kidney Day (WKD) and International Women's coincide. The WKD editorial focuses on women's kidney health. European Renal Association–European Dialysis Transplant Association (ERA-EDTA) Registry Annual Report 2015 summary provides an excellent snapshot of renal replacement therapy (RRT) epidemiology women in Europe. reports a lower incidence RRT major registries potential limitations to access transplantation. What is the situation Europe? Europe, also women: 38% incident...
In this issue of ckj, Tabibzadeh et al. report one the largest series patients with MYH9 mutations and kidney disease. The cardinal manifestation MYH9-related disease is thrombocytopenia giant platelets. population frequency pathogenic may be at least 1 in 20 000. literature abounds misdiagnosed cases treated for idiopathic thrombocytopenic purpura immune suppressants even splenectomy. Additional manifestations include neurosensorial deafness proteinuric hematuric progressive (at some point,...
<b><i>Background/Aims:</i></b> A recent alert from Spanish health authorities warned of a higher incidence reported hypersensitivity reactions to hemodialysis membranes with polysulfone, in the 2017 review acute dialyzers found only published reports 21<sup>st</sup> century on polysulfone and its derivatives. The aim is assess/evaluate current characteristics patients. <b><i>Methods:</i></b> retrospective multicentre study 9...
Key Points Mortality and incidence of AKI do not differ between coronavirus disease 2019 (COVID-19) patients with or without glomerular diseases. The main predictor is pre-COVID-19 eGFR, independent the presence GN. Incomplete kidney function recovery after COVID-19-associated more common in GN than controls. Background acute long-term effects severe respiratory syndrome 2 infection individuals are still unclear. To address this relevant issue, we created International Registry COVID-19...
According to WHO, succinate dehydrogenase (SDH)–deficient renal cell carcinoma is characterized by negative immunostaining for SDHB, which remains positive in non-tumor tissue despite germline mutations the SDHB gene. We now report a patient with mutation, c.166_170del (p.Pro56Tyrfs*5) who developed carcinomas characteristic morphological features of SDH-deficient but had immunostaining. Within 6-year period, two different carcinomas, (uniform cells characteristically displaying eosinophilic...
Atrial fibrillation (AF) is the most common arrhythmia in patients with chronic kidney disease (CKD), and its presence associated a higher risk of stroke mortality.The FAERC study performed retrospective multicentre analysis historical cohorts which data were collected from diagnosis onwards.We analysed Spanish cohort 4749 CKD (mean eGFR 33.9 mL/min) followed up nephrology clinic, observing 12.2% prevalence non-valvular AF. In total, 98.6% these receiving anticoagulant treatment, mainly...
La mortalidad de los pacientes en hemodiálisis es alta. Una tasa ultrafiltración horaria ajustada por peso (UFR/W) elevada se ha asociado con episodios hipotensión arterial y mayor riesgo muerte y/o eventos cardiovasculares. Hemos evaluado la asociación entre UFR/W 215 prevalentes seguidos durante 28 ± 6,12 meses. Se estimaron características clínicas basales media a lo largo del seguimiento. fue 9,0 2,4 terciles 7,1 10,1 mL/kg/h. categorizó población función tiempo que habían estado igual o...
Abstract Background and Aims Gliflozins are a class drugs widely used in diabetes as they act sodium-glucose co-transporter type 2 inhibitors (SGLT2i). Irrespective from glycaemic control, SGLT2i known to possess kidney heart protective effects. The kidney- heart-protective effects of gliflozins (SGLT2i) have received different explanations because their efficacy non-diabetic patients. Indeed, the non-glycemic puzzling SGLT2, molecular target gliflozins, is mainly expressed proximal tubule...