A5060071133- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- Sex work and related issues
- Genital Health and Disease
- Vaccine Coverage and Hesitancy
- Child Nutrition and Water Access
- Female Genital Mutilation/Cutting Issues
- Feminism, Gender, and Sexuality Studies
- Hepatitis Viruses Studies and Epidemiology
- HIV/AIDS oral health manifestations
- Art Therapy and Mental Health
- Cervical Cancer and HPV Research
- Prenatal Substance Exposure Effects
- Pneumonia and Respiratory Infections
- Pregnancy and Medication Impact
- Pneumocystis jirovecii pneumonia detection and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Poverty, Education, and Child Welfare
- HIV/AIDS drug development and treatment
- Vitamin C and Antioxidants Research
- Tuberculosis Research and Epidemiology
- Viral Infections and Immunology Research
Botswana Harvard AIDS Institute Partnership
2016-2024
University of Botswana
2016
University of Maryland, Baltimore
2016
The feasibility of reducing the population-level incidence human immunodeficiency virus (HIV) infection by increasing community coverage antiretroviral therapy (ART) and male circumcision is unknown.
Background Botswana is close to reaching the UNAIDS “90-90-90” HIV testing, antiretroviral treatment (ART), and viral suppression goals. We sought determine incidence in this setting with both high prevalence ART coverage. Methods used a cross-sectional approach assessing incidence. A random, population-based sample of adults age 16–64 years was enrolled 30 rural peri-urban communities as part Combination Prevention Project (BCPP), from October 2013 –November 2015. Data samples baseline...
Poloko Kebaabetswea, Kutlo Manyakea, Etienne Kadimaa, Chloe Auletta-Youngb, Unoda Chakalisaa, Tumalano Sekotoa, Oarabile Makgabana Dintwaa†, Mompati Mmalanea, Joseph Makhemaa, Refeletswe Lebelonyanec, Pamela Bachanasd, Rebeca Plankbe‡, Tendani Gaolathea, Shahin Lockmanabe & Molly Pretorius Holmeb*a Botswana Harvard AIDS Institute Partnership, Gaborone, Botswanab Harvard. T.H. Chan School of Public Health, Boston, MA, USAc Ministry Health and Wellness, Botswanad Centers for Disease Control...
HIV-1 RNA load is the best biological predictor of HIV transmission and treatment response. The rate virologic suppression among key subpopulations can guide prevention programs.The Botswana Combination Prevention Project performed a population-based household survey adults in 30 communities Botswana. Data collected included knowledge HIV-positive status, antiretroviral therapy (ART) coverage, (HIV-1 ≤400 copies per milliliter). Individuals aged 16-29 years were considered young adults.Among...
Abstract Background Phylogenetic mapping of HIV-1 lineages circulating across defined geographical locations is promising for better understanding HIV transmission networks to design optimal prevention interventions. Methods We obtained near full-length genome sequences from people living with (PLWH), including participants on antiretroviral treatment in the Botswana Combination Prevention Project, conducted 30 communities 2013–2018. relationships among viral were estimated by maximum...
Introduction Non-citizens often face barriers to HIV care and treatment. Quantifying knowledge of positive status antiretroviral therapy (ART) coverage among non-citizens in a high HIV-prevalence country like Botswana that is close achieving UNAIDS "90-90-90" targets may expose important gaps universal testing Methods The Combination Prevention Project (BCPP) pair-matched cluster-randomized trial evaluating the impact prevention interventions on incidence 30 rural or peri-urban communities....
Additional strategies are needed to prevent and treat tuberculosis (TB). Although vitamin D may have antimycobacterial effects, it is unknown whether low status confers a risk for active TB in African children. This case-control study assessed serum 25-hydroxyvitamin (25(OH)D) concentration children with without Gaborone, Botswana. A total of 80 under 2 years old TB, seen at hospitals clinics the greater Gaborone area between September 2010 November 2012, were enrolled. Of these, 39 cases...
We describe rotavirus testing and clinical characteristics for children admitted with acute gastroenteritis during Botswana's 2011 season. The season extended from June to October rotavirus-specific case fatality being 2.8%. Using molecular as reference, the immunochromatographic test had a sensitivity of 76.5% specificity 68.0%. Rotavirus vaccine may significantly reduce childhood morbidity mortality in Botswana.
Background: Adolescents and young adults account for more than one-third of incident Human Immunodeficiency Virus (HIV) infections globally. Understanding sexual practices this high-risk group is critical in designing HIV targeted prevention programming. Objectives: To describe self-reported risky adolescents aged 16–24 years from 30 Botswana communities. Methods: Cross-sectional, age at debut; number partners; condom alcohol use during sex; intergenerational transactional sex data were...
Abstract Background Human immunodeficiency virus 1 (HIV-1) antiretroviral therapy (ART) alters hormonal contraceptive levels delivered via intravaginal ring (IVR) in a regimen-specific manner. We explored the role of IVR on vaginal microbial communities, short chain fatty acids (SCFAs), HIV shedding, and effect microbes hormone concentrations cisgender women with (WWH). Methods Vaginal were assessed by 16S RNA sequencing weekly swabs, SCFA mass spectrometry, HIV-1 shedding nucleic acid...
To identify predictors of HIV acquisition in Botswana.
Cervical cancer is a common worldwide, with > 85% of deaths occurring in Lower- and Middle-Income Countries where resources for screening programs are limited. Women living HIV (WLHIV) at increased risk. HPV test-and-treat strategy women offered ablative treatment the cervix to reduce risk invasive cancer. WLHIV tend have more extensive cervical lesions, necessitating specialised surgical treatments.
HIV-1 RNA level is strongly associated with HIV transmission risk. We sought to determine whether was prior knowledge of status among treatment-naive HIV-infected individuals in Botswana, a country high rates antiretroviral treatment (ART) coverage. This information may be helpful targeting diagnosis and efforts similar prevalence settings population-based survey. were identified during household survey performed 30 communities across Botswana. ART-naive persons detectable (>400 copies/mL)...
Abstract Background This exploratory analysis investigates the prevalence and risk factors of neurocognitive toxicity in postpartum women on HIV treatment response to a concern an Isoniazid Preventive Therapy (IPT)/Efavirenz interaction. Trial Design Pregnant from countries with high TB were randomized IMPAACT P1078 28 weeks IPT started either during pregnancy or at 12 postpartum. Partway through study implementation, Patient Health Questionnaire 9, cognitive complaint questionnaire,...
Understanding factors associated with prevalent Mycobacterium tuberculosis infection and TB disease in household contacts of patients drug-resistant (TB) may be useful for program staff conducting contact investigations.
Background: Hospital-acquired infections, including hospital-acquired gastroenteritis (HAGE), are well documented in Western countries but little is known about these infections sub-Saharan Africa. Aim: To determine the incidence of and explore modifiable risk factors for HAGE. Methods: A prospective cohort study children 72 hours after admission or upon recent discharge a non-GE illness. Children were followed until to ascertain therapies used adverse outcomes. Enteric pathogens...
Background: Hospital-acquired infections, including hospital-acquired gastroenteritis (HAGE), are well documented in Western countries but little is known about these infections sub-Saharan Africa. Aim: To determine the incidence of and explore modifiable risk factors for HAGE. Methods: A prospective cohort study children 72 hours after admission or upon recent discharge a non-GE illness. Children were followed until to ascertain therapies used adverse outcomes. Enteric pathogens identified...