A5088267373- Data-Driven Disease Surveillance
- Influenza Virus Research Studies
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Bipolar Disorder and Treatment
- Smoking Behavior and Cessation
- Cardiac Imaging and Diagnostics
- COVID-19 epidemiological studies
- Respiratory viral infections research
- Pregnancy and Medication Impact
- Iron Metabolism and Disorders
- Prenatal Screening and Diagnostics
- Advanced MRI Techniques and Applications
- Nuclear Structure and Function
- Hemoglobinopathies and Related Disorders
- Pharmacological Effects and Toxicity Studies
- Acute Myocardial Infarction Research
- Species Distribution and Climate Change
- Child and Adolescent Psychosocial and Emotional Development
- Prenatal Substance Exposure Effects
- Folate and B Vitamins Research
- COVID-19 Impact on Reproduction
- Mental Health Treatment and Access
- Radiomics and Machine Learning in Medical Imaging
Cancer Research And Biostatistics
2020-2025
Boston University
2016-2023
Boston Children's Hospital
2015-2018
Brigham and Women's Hospital
2017
China Medical University
2017
Harvard University
2017
Oregon Health & Science University
2017
Massachusetts General Hospital
2017
VA Boston Healthcare System
2017
Framingham Heart Study
2017
We summarized Flu Near You (FNY) data from the 2012-2013 and 2013-2014 influenza seasons in United States.FNY collects limited demographic characteristic information upon registration, prompts users each Monday to report symptoms of influenza-like illness (ILI) experienced during previous week. calculated descriptive statistics rates ILI for seasons. compared raw noise-filtered with Centers Disease Control Prevention ILINet surveillance system.More than 61 000 participants submitted at least...
Background— The presence and extent of coronary artery calcium (CAC) are associated with increased risk for cardiovascular events. We determined whether information on the distribution CAC dominance as detected by cardiac computed tomography were incremental to traditional Agatston score (AS) in predicting incident major heart disease (CHD). Methods Results— assessed total AS per artery, segment, participants from offspring third-generation cohorts Framingham Heart Study. primary outcome was...
Influenza outbreaks pose major challenges to public health around the world, leading thousands of deaths a year in United States alone. Accurate systems that track influenza activity at city level are necessary provide actionable information can be used for clinical, hospital, and community outbreak preparation.Although Internet-based real-time data sources such as Google searches tweets have been successfully produce estimates ahead traditional care-based national state levels, tracking...
Flu Near You (FNY) is an Internet-based participatory surveillance system in the United States and Canada that allows volunteers to report influenza-like symptoms using a brief weekly symptom report.Our objective was evaluate representativeness of FNY population compared with general States, explore demographic behavioral characteristics associated FNY's high-participation users, summarize results from user survey cohort participants.We (1) sex age groups participants during 2014-2015 flu...
Influenza causes an estimated 3000 to 50,000 deaths per year in the United States of America (US). Timely and representative data can help local, state, national public health officials monitor respond outbreaks seasonal influenza. Data from cloud-based electronic records (EHR) crowd-sourced influenza surveillance systems have potential provide complementary, near real-time estimates activity. The objectives this paper are compare two novel influenza-tracking with three traditional...
Purpose To extract radiomic features from coronary artery calcium (CAC) on CT images and to determine whether this approach could improve the ability identify individuals at risk for a composite endpoint of clinical events. Materials Methods Participants Offspring Third Generation cohorts community-based Framingham Heart Study underwent noncontrast cardiac (2002–2005) were followed more than median 9.1 years major A total 624 participants with CAC Agatston score (AS) greater 0 good or...
Abstract Background Pregnant people with coronavirus disease 2019 (COVID-19) experience higher risk for severe and adverse pregnancy outcomes, but no pharmacokinetic (PK) data exist to support dosing of COVID-19 therapeutics during pregnancy. We report PK safety intravenous remdesivir in Methods IMPAACT 2032 was a phase 4 prospective, open-label, nonrandomized opportunistic study hospitalized pregnant nonpregnant women receiving as part clinical care. Intensive sampling performed on infusion...
Flu Near You (FNY) is an online participatory syndromic surveillance system that collects health-related information. In this article, we summarized the healthcare-seeking behavior of FNY participants who reported influenza-like illness (ILI) symptoms.We applied inverse probability weighting to calculate age-adjusted estimates percentage in United States sought health care for ILI symptoms during 2015-2016 through 2018-2019 influenza season and compared seasonal trends across different...
The Centers for Disease Control and Prevention (CDC) tracks influenza-like illness (ILI) using information on patient visits to health care providers through the Outpatient Influenza-like Illness Surveillance Network (ILINet). As participation in this system is voluntary, composition, coverage, consistency of reports vary from state state, leading different measures ILI activity between regions. degree which these reflect actual differences influenza or systematic methods used collect...
We assessed bone and kidney outcomes in infants randomized postdelivery as mother-infant pairs within the IMPAACT PROMISE trial to maternal tenofovir disoproxil fumarate-based antiretroviral treatment (mART) or infant nevirapine prophylaxis (iNVP) prevent breastfeeding HIV transmission.Infants were coenrolled P1084s substudy on randomization day followed through Week 74. Lumbar spine mineral content (LS-BMC) was at entry (6-21 age days) 26 by dual-energy x-ray absorptiometry. Creatinine...
Background: Primary results of the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) 2002 trial showed that cognitive behavioural therapy (CBT) and medication management algorithm (MMA) (COMB-R) significantly improved depression in youth with HIV (YWH) compared enhanced standard care (ESC). Acceptability satisfaction were examined among study participants clinicians.Method: Between March 2017 2019, 13 U.S. sites enrolled YWH, aged 12-24, diagnosed...
Abstract Background Tenofovir disoproxil fumarate (TDF) in combination with other antiretroviral (ARV) drugs has been clinical use for HIV treatment since its approval 2001. Although the effectiveness of TDF preventing perinatal infection is well established, information about renal safety during pregnancy still limited. Trial design The IMPAACT PROMISE study was an open-label, strategy trial that randomized pregnant women to one three arms: based therapy (ART), zidovudine (ZDV) ART, and ZDV...
ObjectiveTo estimate and compare influenza attack rates (AR) in the United States (US) using different approaches to adjust for reporting biases participatory syndromic surveillance data.IntroductionBecause dynamics severity of US vary each season, yearly estimates disease burden population are essential evaluate interventions allocate resources. The CDC uses data from a national health-care based system mathematical models overall general population. Over past decade, crowd-sourced systems...
Over the past fifteen years, infectious disease surveillance has evolved to include online citizen science projects that implement active digital data collection. Flu Near You (FNY) is an participatory system in United States collects weekly health reports from its volunteers. Because high engagement levels and consistent participation of users are essential accurately track estimate burden, FNY implemented three measures: (1) adding a new feature allows website visitors submit report...
Studies suggest that manualized, measurement-guided, depression treatment is more efficacious than usual care but impact can wane. Our study among youth with HIV (YWH), aged 12-24 years at US clinical research sites in the International Maternal Pediatric Adolescent AIDS Clinical Trials Network, found a significant reduction depressive symptoms YWH who received measurement-guided treatment. This paper reports outcomes up to 24 weeks after intervention. Eligibility included diagnosis of...
Abstract Background This exploratory analysis investigates the prevalence and risk factors of neurocognitive toxicity in postpartum women on HIV treatment response to a concern an Isoniazid Preventive Therapy (IPT)/Efavirenz interaction. Trial Design Pregnant from countries with high TB were randomized IMPAACT P1078 28 weeks IPT started either during pregnancy or at 12 postpartum. Partway through study implementation, Patient Health Questionnaire 9, cognitive complaint questionnaire,...