Vanessa Douet

ORCID: 0000-0002-5162-8944
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About
Contact & Profiles
Research Areas
  • Caveolin-1 and cellular processes
  • Congenital heart defects research
  • Genetics and Neurodevelopmental Disorders
  • Dermatological and Skeletal Disorders
  • Cognitive Abilities and Testing
  • Kruppel-like factors research
  • Plant-Microbe Interactions and Immunity
  • Proteoglycans and glycosaminoglycans research
  • Plant Pathogenic Bacteria Studies
  • Skin and Cellular Biology Research
  • Functional Brain Connectivity Studies
  • Legume Nitrogen Fixing Symbiosis
  • HIV Research and Treatment
  • Hemispheric Asymmetry in Neuroscience
  • Bipolar Disorder and Treatment
  • Selenium in Biological Systems
  • RNA Research and Splicing
  • Genomic variations and chromosomal abnormalities
  • Autism Spectrum Disorder Research
  • HIV-related health complications and treatments
  • Cell Adhesion Molecules Research
  • Tryptophan and brain disorders
  • Neurogenesis and neuroplasticity mechanisms
  • COVID-19 Clinical Research Studies
  • Amyloidosis: Diagnosis, Treatment, Outcomes

Université Côte d'Azur
2023-2024

Cognition Behaviour Technology
2024

Cambia
2022

University of Hawaiʻi at Mānoa
2006-2017

John Wiley & Sons (United States)
2017

Hudson Institute
2017

University of Hawaii System
2006-2016

Queen's Medical Center
2014-2016

University of California, San Diego
2016

Yale University
2016

<h3>Objective:</h3> The aims of the current study were to determine whether children with 6 different <i>APOE</i> ε genotypes show differences in gray matter maturation, particularly for those ε4 and ε2 alleles, which are associated poorer outcomes many neurologic disorders. <h3>Methods:</h3> A total 1,187 healthy (aged 3–20 years, 52.1% boys, 47.9% girls) acceptable data from cross-sectional Pediatric Imaging Neurocognition Genetics Study evaluated effects on macroscopic microscopic...

10.1212/wnl.0000000000002939 article EN Neurology 2016-07-14

<h3>Objective:</h3> We aimed to evaluate the combined effects of HIV and <i>APOE</i> ε4 allele(s) on glial metabolite levels, known cognitive deficits associated with either condition, across ages. <h3>Methods:</h3> One hundred seventy-seven participants, primarily white mixed race (97 seronegative subjects: aged 44.7 ± 1.3 years, 85 [87.6%] men, 28 [28.9%] ε4+; 80 HIV+ 47.3 1.1 73 [91.3%] 23 [28.8%] ε4+), were assessed cross-sectionally for concentrations using proton magnetic resonance...

10.1212/wnl.0000000000000526 article EN Neurology 2014-05-22

Attention-deficit hyperactivity disorder (ADHD) occurs in 5.9% of youth, impacting their health and social conditions often across lifespan. Currently, early diagnosis is constrained by clinical complexity limited resources professionals to conduct evaluations. Scalable methods for ADHD screening are thus needed. Recently, digital epidemiology biometry, such as the visual, emotional, or digit pathway, have examined brain dysfunction individuals. However, whether biometry can support symptoms...

10.3389/fpsyt.2025.1466107 article EN cc-by Frontiers in Psychiatry 2025-03-17

Abstract Objectives : Fractones are extracellular matrix structures that form a niche for neural stem cells and their immediate progeny in the subventricular zone of lateral ventricle (SVZa), primary neurogenic adult brain. We have previously shown heparan sulphates (HS) associated with fractones bind fibroblast growth factor‐2 (FGF‐2), powerful mitotic factor SVZa. Here, our objective was to determine whether binding FGF‐2 fractone‐HS is implicated mechanism leading cell proliferation...

10.1111/cpr.12023 article EN Cell Proliferation 2013-03-19

Asthma can progress to subepithelial airway fibrosis, mediated in large part by transforming growth factor-beta (TGF-beta). The scaffolding protein caveolin-1 (cav1) inhibit the activity of TGF-beta, perhaps forming membrane invaginations that enfold TGF-beta receptors. study goals were 1) evaluate how allergen challenge affects lung expression cav1 and density caveolae vivo 2) determine whether reduced is interleukin (IL)-4 3) measure effects decreased on signaling. C57BL/6J, IL-4-deficient...

10.1074/jbc.m701572200 article EN cc-by Journal of Biological Chemistry 2007-12-04

Objective We aimed to evaluate the effectiveness of an adaptive working memory (WM) training (WMT) program, corresponding neural correlates, and LMX 1A‐rs4657412 polymorphism on WMT, in human immunodeficiency virus (HIV) participants compared seronegative (SN) controls. Methods A total 201 206 qualified completed baseline assessments before randomization 25 sessions WMT or nonadaptive WMT. 74 76 (34 HIV, 42 SN) all 40 (20 20 were assessed after 1 month, 55 also 6 months. Nontrained...

10.1002/ana.24805 article EN cc-by-nc-nd Annals of Neurology 2016-10-20

The neuregulin-1 (NRG1) gene is one of the best-validated risk genes for schizophrenia, and psychotic bipolar disorders. rs6994992 variant in NRG1 promoter (SNP8NRG243177) associated with altered frontal temporal brain macrostructures and/or white matter density integrity schizophrenic adults, as well healthy adults neonates. However, ages when these changes begin whether neuroimaging phenotypes are cognitive performance not fully understood. Therefore, we investigated association on...

10.1038/tp.2014.41 article EN cc-by-nc-sa Translational Psychiatry 2014-05-27

Potent combined antiretroviral therapy decreased the incidence and severity of HIV-associated neurocognitive disorders (HAND); however, no specific effective pharmacotherapy exists for HAND. Patients with HIV commonly have deficits in working memory attention, which may negatively impact many other cognitive domains, leading to Since HAND lead loss independence activities daily living negative emotional well-being, incur a high economic burden, treatments are urgently needed. This study aims...

10.1186/s13063-016-1160-4 article EN cc-by Trials 2016-02-02

ABSTRACT The type II secretion (T2S) system is an essential device for Erwinia chrysanthemi virulence. Previously, we reported the key role of OutF protein in forming, along with OutELM, inner membrane platform Out T2S system. Here, report that copurified five proteins identified by matrix-assisted laser desorption ionization-time flight analysis as AcsD, TogA, SecA, Tsp, and DegP. AcsD was known to be involved biosynthesis achromobactin, which a siderophore important E. yeast two-hybrid...

10.1128/jb.00845-08 article EN Journal of Bacteriology 2008-11-01
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