A5051782798- Ubiquitin and proteasome pathways
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Hedgehog Signaling Pathway Studies
- Protein Degradation and Inhibitors
- Glycosylation and Glycoproteins Research
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- Microtubule and mitosis dynamics
- Genetic Syndromes and Imprinting
- Renal cell carcinoma treatment
- Chromatin Remodeling and Cancer
Laboratoire de Chimie de Coordination
2021-2025
Centre National de la Recherche Scientifique
2025
Institut de Recherche pour le Développement
2021-2022
Pharmacochimie et Pharmacologie pour le Développement
2021-2022
Université Toulouse III - Paul Sabatier
2021-2022
CIC bioGUNE
2018-2021
Institut Technique de l'Aviculture
2020
Institut de Pharmacologie et de Biologie Structurale
2020
Institut des Technologies Avancées en sciences du Vivant
2020
Primary cilia are sensory organelles crucial for cell signaling during development and organ homeostasis. Cilia arise from centrosomes their formation function is governed by numerous factors. Through our studies on Townes-Brocks Syndrome (TBS), a rare disease linked to abnormal in human fibroblasts, we uncovered the leucine-zipper protein LUZP1 as an interactor of truncated SALL1, dominantly-acting causing disease. Using TurboID proximity labeling pulldowns, show that associates with...
Resistance to bortezomib (BTZ) represents a major bottleneck continue using this proteasome inhibitor in the treatment of mantle cell lymphoma (MCL). In study, we investigated mechanisms by which TRIM24 (tripartite motif-containing 24), ubiquitin ligase enriched ubiquitome BTZ-resistant MCL cells, modulates proteasome-autophagy crosstalk. The localization and stability were differentially influenced inhibition or autophagy cells with acquired BTZ resistance (ZBR). Moreover, genetic deletion...
Townes-Brocks syndrome (TBS) is characterized by a spectrum of malformations in the digits, ears, and kidneys. These anomalies overlap those seen growing number ciliopathies, which are genetic syndromes linked to defects formation or function primary cilia. TBS caused mutations gene encoding transcriptional repressor SALL1 associated with presence truncated protein that localizes cytoplasm. Here, we provide evidence might cause means beyond its capacity. By using proximity proteomics, show...
LUZP1 is a centrosomal and actin cytoskeleton-localizing protein that regulates both ciliogenesis filament bundling. As the cytoskeleton cilia are implicated in metastasis tumor suppression, we examined roles for context of cancer. Here show exhibits frequent genomic aberrations cancer, with predominance gene deletions. Furthermore, demonstrate CRISPR/Cas9-mediated loss Luzp1 mouse fibroblasts promotes cell migration invasion features, reduces viability, increases apoptosis, centriole...
Protein ubiquitylation coordinates crucial cellular events in physiological and pathological conditions. A comparative analysis of the ubiquitin proteome from bortezomib (BTZ)-sensitive BTZ-resistant mantle cell lymphoma (MCL) revealed an enrichment autophagy-lysosome system (ALS) cells. Pharmacological inhibition autophagy at level lysosome-fusion a constitutive activation proteaphagy accumulation proteasome subunits within autophagosomes different MCL lines with acquired or natural...
Acute myeloid leukaemia (AML) is a clonal disorder that affects hematopoietic stem cells or progenitors. One of the most common mutations results in AML occurs gene encoding fms‐like tyrosine kinase 3 ( FLT3 ). Previous studies have demonstrated expressing FLT3‐internal tandem duplication (ITD) are more sensitive to proteasome inhibitor bortezomib (Bz) than wild‐type cells, with this cytotoxicity being mediated by autophagy (Atg). Here, we show inhibition Bz modest but consistent proteaphagy...
ABSTRACT Primary cilia are sensory organelles that crucial for cell signaling during development and organ homeostasis. Cilia arise from the centrosome their formation is governed by numerous regulatory factors. We show leucine-zipper protein LUZP1 localizes to pericentriolar material actin cytoskeleton. Using TurboID proximity labeling pulldowns, associates with factors linked filaments. Loss of reduces F-actin levels, facilitating ciliogenesis altering Sonic Hedgehog signaling, pointing a...