A5081741154- Fatty Acid Research and Health
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Lipid metabolism and biosynthesis
- Biochemical Analysis and Sensing Techniques
- Nutrition and Health in Aging
- Dye analysis and toxicity
- Advanced Chemical Sensor Technologies
- Lipid metabolism and disorders
- Eicosanoids and Hypertension Pharmacology
- Curcumin's Biomedical Applications
- Cholesterol and Lipid Metabolism
- Retinal Diseases and Treatments
- Aging and Gerontology Research
- Evasion and Academic Success Factors
- Coconut Research and Applications
- Iron Metabolism and Disorders
- Public Health in Brazil
- Technology Use by Older Adults
- Retinal Imaging and Analysis
- Health disparities and outcomes
Macquarie University
2019-2023
University of Newcastle Australia
2013-2021
Massey University
2018-2019
Riddet Institute
2018-2019
Callaghan Innovation
2018
Palmerston North Hospital
2018
Hunter Medical Research Institute
2015
Dietary supplementation with curcumin has been previously reported to have beneficial effects in people insulin resistance, type 2 diabetes (T2D) and Alzheimer’s disease (AD). This study investigated the of dietary on key peptides implicated resistance individuals high risk developing T2D. Plasma samples from participants recruited for a randomised controlled trial (180 mg/day) 12 weeks were analysed circulating glycogen synthase kinase-3 β (GSK-3β) islet amyloid polypeptide (IAPP). Outcome...
This study examined the impacts of COVID-19 lockdown on health and lifestyle factors for older adults in Sydney, Australia. The demographic differences, social engagement, loneliness, physical activity, emotion regulation, technology use, grandparenting experiences their contribution to emotional quality life during lockdown.Participants were 201 community-dwelling (60-87 years, M = 70.55, SD 6.50; 67.8% female) who completed self-report scales measuring outcomes, life, service utilization,...
There is a growing incidence of cognitive decline and dementia associated with the ageing population. Lifestyle factors such as diet, physical activity, activities may individually or collectively be undertaken to increase one's odds preventing future dementia. This study will examine whether clinical trials using multidomain lifestyle intervention can significantly decrease risk therefore systematic literature review interventions for prevention followed PRISMA guidelines. Clinical...
The structural similarity among lipid species and the low sensitivity spectral resolution of nuclear magnetic resonance (NMR) have traditionally hampered routine use 1H NMR profiling complex biological samples in metabolomics, which remains mostly manual lacks freely available bioinformatics tools. However, provides fast quantitative screening major classes (fatty acids, glycerolipids, phospholipids, sterols) some individual has been used several clinical nutritional studies, leading to...
Aberrant amyloid-β (Aβ) deposition in the brain occurs two decades prior to manifestation of Alzheimer's disease (AD) clinical symptoms and therefore Aβ load measured using PET serves as a gold standard biomarker for early diagnosis AD. However, uneconomical nature makes blood markers, that reflect deposition, attractive candidates investigation surrogate markers. Investigation plasma marker cognitively normal elderly individuals. Plasma Aβ40 Aβ42 concentrations were ultrasensitive Single...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently has no cure. Identifying biochemical changes associated with neurodegeneration prior to symptom onset, will provide insight into the biological mechanisms processes, may also aid in identifying potential drug targets. The current study therefore investigated associations between plasma neurofilament light chain (NF-L), marker of neurodegeneration, metabolites are products various cellular processes. Plasma...
As the food matrix is a determinant of rate fat digestion and absorption, it important for modulation postprandial triglyceridaemia.
In the current study, we aimed to evaluate effects of a single dose curcumin and/or fish oil on postprandial glycaemic parameters in healthy individuals. This was randomised, placebo-controlled and crossover study. Sixteen (n = 16) volunteers were randomised receive placebo, (180 mg) tablets, (1.2 g long chain omega-3 polyunsaturated fatty acids) capsules + prior standard meal 4 test days separated by week. Blood glucose, serum insulin triglycerides measured at intervals between 0-120 min....
Dietary saturated fat (SFA) intake has been associated with elevated blood lipid levels and increased risk for the development of chronic diseases. However, some animal studies have demonstrated that dietary SFA may not raise when diet is sufficient in omega-3 polyunsaturated fatty acids (n-3PUFA). Therefore, a randomised cross-over design, we investigated postprandial effects feeding meals rich either (butter) or vegetable oil omega-6 (n-6PUFA), conjunction n-3PUFA, on profiles [total...
Targeting kinases linked to insulin resistance (IR) and inflammation may help in reducing the risk of type 2 diabetes (T2D) Alzheimer’s disease (AD) its early stages. This study aimed determine whether DHA-rich fish oil supplementation reduces glycogen synthase kinase (GSK-3), which is both IR AD. Baseline post-intervention plasma samples from 58 adults with abdominal obesity (Age: 51.7 ± 1.7 years, BMI: 31.9 0.8 kg/m2) were analysed for outcome measures. Participants allocated g capsules...
Abstract Background The highly encouraging findings from the Finnish Geriatric Intervention Study (known as FINGER) led to global initiative for dementia risk reduction known world‐wide FINGERS (WW FINGERS). As part of collaboration, our Australian AU‐ARROW trial will follow general protocol FINGER trial, and also be aligned with U.S. arm study, US‐POINTER, though have minor cultural dietary modifications determine validity intervention in an setting. Method is a randomised, single‐blind...
Background/Objective: Hepcidin, an iron-regulating hormone, suppresses the release of iron by binding to exporter protein, ferroportin, resulting in intracellular accumulation.Given that dyshomeostasis has been observed Alzheimer's disease (AD) together with elevated serum hepcidin levels, current study examined whether levels are early event AD pathogenesis measuring hormone cognitively normal older adults at risk AD, based on high neocortical amyloid- load (NAL).