A5046381456- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- Sports Performance and Training
- Dementia and Cognitive Impairment Research
- Fatty Acid Research and Health
- Health and Lifestyle Studies
- Exercise and Physiological Responses
- Thermoregulation and physiological responses
- Reproductive Health and Contraception
- Aging and Gerontology Research
- Coconut Research and Applications
- Birth, Development, and Health
- Alzheimer's disease research and treatments
- Blood Pressure and Hypertension Studies
- Frailty in Older Adults
- Bipolar Disorder and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tryptophan and brain disorders
- Folate and B Vitamins Research
- Health disparities and outcomes
- Muscle metabolism and nutrition
- Mitochondrial Function and Pathology
- Technology Use by Older Adults
Macquarie University
2020-2023
Hunter Water
2021
University of Newcastle Australia
2015
This study examined the impacts of COVID-19 lockdown on health and lifestyle factors for older adults in Sydney, Australia. The demographic differences, social engagement, loneliness, physical activity, emotion regulation, technology use, grandparenting experiences their contribution to emotional quality life during lockdown.Participants were 201 community-dwelling (60-87 years, M = 70.55, SD 6.50; 67.8% female) who completed self-report scales measuring outcomes, life, service utilization,...
There is a growing incidence of cognitive decline and dementia associated with the ageing population. Lifestyle factors such as diet, physical activity, activities may individually or collectively be undertaken to increase one's odds preventing future dementia. This study will examine whether clinical trials using multidomain lifestyle intervention can significantly decrease risk therefore systematic literature review interventions for prevention followed PRISMA guidelines. Clinical...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently has no cure. Identifying biochemical changes associated with neurodegeneration prior to symptom onset, will provide insight into the biological mechanisms processes, may also aid in identifying potential drug targets. The current study therefore investigated associations between plasma neurofilament light chain (NF-L), marker of neurodegeneration, metabolites are products various cellular processes. Plasma...
Abstract Objective This study assessed the long‐term symptom relapse rates among older adults previously treated with cognitive behaviour therapy (CBT) for anxiety and/or depression during COVID‐19. Methods Participants were 37 ( M = 75 years, SD 5; 65% female) CBT unipolar who re‐assessed an average of 5.6 years later, first Australian COVID‐19 lockdown. Results On average, there was no significant group‐level change in anxiety, or quality life. When assessing symptoms based on clinical...
Abstract Background The highly encouraging findings from the Finnish Geriatric Intervention Study (known as FINGER) led to global initiative for dementia risk reduction known world‐wide FINGERS (WW FINGERS). As part of collaboration, our Australian AU‐ARROW trial will follow general protocol FINGER trial, and also be aligned with U.S. arm study, US‐POINTER, though have minor cultural dietary modifications determine validity intervention in an setting. Method is a randomised, single‐blind...
Abstract Background The Finnish Geriatric Intervention Study (FINGER) reported that a multidomain lifestyle intervention could provide an effective and accessible means of protecting against age‐related cognitive decline dementia. This led to the global dementia risk reduction initiative: World‐Wide FINGERS (WW‐FINGERS). As part WW‐FINGERS, AU‐ARROW study mirrors aspects FINGER, as well U.S. (US‐POINTER, also WW‐FINGERS), while allowing for Australian cultural dietary adaptations. Method is...
Abstract Background Alzheimer’s disease (AD) neuropathology begins 20 to 30 years before clinical diagnosis. Thus, there is an opportunity implement strategies prevent the progression of AD. Insulin resistance in brain causes a disruption glucose utilisation. Medium‐chain fatty acids (MCFA) are readily available substrates for synthesis ketone bodies (KB), which alternative fuel not controlled by insulin. A constant supply KB may close energy gap AD‐prone brain, and doing so or delay symptom...
Abstract Background Medium‐chain fatty acids (MCFA) are quickly absorbed and transported to the liver. Where they preferentially metabolised into energy ketone bodies, as compared long‐chain acids. Ketone bodies then brain other tissues for supply. This makes MCFA ideal source patients with conditions in which deprivation is observed, such Alzheimer’s disease (AD). In AD, insulin resistance causes partial glucose deprivation. However, still able use energy. Despite potential, our knowledge,...
Abstract Background Medium‐chain triglycerides (MCT), unlike other type of fats, are quickly digested into medium‐chain fatty acids (MCFA), which metabolized by the liver energy in form ketones. Ketones then transported to brain for supply. In Alzheimer’s disease (AD), becomes less efficient glucose uptake and metabolism, resulting an deficiency. The only backup source is this study we examined potential MCT serve as a fuel during deprivation, such what observed AD. Method Healthy males...