A5081478888- HIV/AIDS Research and Interventions
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Syphilis Diagnosis and Treatment
- Nail Diseases and Treatments
- HIV/AIDS drug development and treatment
- Science and Education Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- HIV-related health complications and treatments
- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Reproductive tract infections research
- COVID-19 Clinical Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Long-Term Effects of COVID-19
- Sex work and related issues
- COVID-19 and healthcare impacts
- Animal Disease Management and Epidemiology
- LGBTQ Health, Identity, and Policy
- Healthcare during COVID-19 Pandemic
- Bacterial Infections and Vaccines
- Psychology and Mental Health
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
Universidade Federal do Rio Grande do Norte
2019-2025
Instituto de Medicina Tropical
2023
Hospital de Clínicas de Porto Alegre
2010-2012
Universidade Federal do Rio Grande do Sul
2010-2012
Histoplasmosis is highly endemic in the American continent. This condition associated with a high mortality, particularly people living HIV/AIDS (PLWHA). Diagnosis of histoplasmosis usually late South America, as Histoplasma antigen detection rarely available. Here we determined prevalence, risk factors, and outcome PLWHA Brazilian hospitals. was prospective cohort study (2016–2018) involving 14 tertiary medical centers Brazil. We included hospitalized presenting fever additional clinical...
This study aimed to analyse the survival of patients admitted Brazilian hospitals due COVID-19 and estimate prognostic factors. is a retrospective, multicentre cohort study, based on data from 46 285 hospitalisations for in Brazil. Survival functions were calculated using Kaplan–Meier's method. The log-rank test compared each variable that, hazard ratios (HRs) calculated, proportional model was used Cox multiple regression. smallest curves ones at age 68 years or more, black/mixed race,...
Abstract Background Histoplasmosis is a major AIDS-defining illness in Latin America. Liposomal amphotericin B (L-AmB) the drug of choice for treatment, but access restricted due to high and hospitalization costs conventional long regimens. Methods Prospective randomized multicenter open-label trial 1- or 2-dose induction therapy with L-AmB versus control disseminated histoplasmosis AIDS, followed by oral itraconazole therapy. We subjects to: (i) single dose 10 mg/kg L-AmB; (ii) on D1, 5 D3;...
Background To determine the prevalence and associated factors with chronic kidney disease (CKD) in a cohort of HIV-positive individuals undetectable viral load on HAART. Methods From March, 2009 to September 2009, 213 between 18-70 years, period HAART ≥12 months, < 50 copies/mm3, CD4 ≥ 200 cells/mm3, were consecutively enrolled at outpatient clinic Hospital de Clínicas, Porto Alegre, Brazil. Exclusion criteria obesity, malnourishment, amputee, paraplegic, previous history renal disease,...
<title>Abstract</title> The Clinical Outcomes of Dolutegravir Treatment in People Living with HIV Brazil (CODE) cohort study is a multicenter, prospective, observational designed to evaluate the safety and efficacy (DTG)-based antiretroviral therapy (ART) among people living across diverse settings Brazil. With recent global shift towards DTG as preferred option for first-line ART, particularly low- middle-income countries, there vital need comprehensive real-world data inform its widespread...
Background Human T cell lymphotropic virus type 1 (HTLV-1) is highly endemic in Brazil, necessitating surveillance studies to understand its epidemiology. While previous research has focused on either specific cities or populations, there a need for multicenter encompassing epidemiologically relevant populations ascertain more accurate prevalence rates and predictors of HTLV-1 infection the country. Methods We conducted multicenter, cross-sectional study involving 3,184 participants across...
Cryptococcosis is a common opportunistic infection in patients infected by Human Immunodeficiency Virus (HIV) and the second leading cause of mortality Acquired Syndrome (AIDS) worldwide. The most frequent presentation cryptococcal subacute meningitis, especially with CD4+ T Lymphocytes count below 100 cells/μL. However, severely immunosuppressed individuals Cryptococcus neoformans can infect virtually any human organ, including bone marrow, which rare cryptococcosis. A 45-year-old...
Histoplasmosis is a neglected disease that affects mainly immunocompromised patients, presenting progressive dissemination pattern and high mortality rate, due to delayed diagnosis, caused by slow fungal growth in culture. Therefore, fast, suitable cost-effective assay required for the diagnosis of histoplasmosis resource-limited laboratories. This study aimed develop evaluate two new molecular approaches more histoplasmosis.Seeking suitable, sensitive, specific low-cost detection technique,...
To (i) describe the nationwide antimicrobial susceptibility of Neisseria gonorrhoeae (NG) isolates cultured across Brazil in 2018-20 and compare it with NG resistance data from 2015-16, (ii) present epidemiological corresponding gonorrhoea patients 2018-20.Twelve representative sentinel sites men urethral discharge. Susceptibility to eight antimicrobials was examined using agar dilution method, according WHO standards. The consenting participants were invited provide data.In total, 633 (one...
Men who have sex with men (MSM) account for the highest prevalence of HIV in Brazil. testing allows to implement preventive measures, reduces transmission, morbidity, and mortality. We conducted a cross-sectional study evaluate during lifetime, factors associated decision test, knowledge about use condoms between MSM from city Natal, northeast Out 99 participants, 62.6% had been tested 46.2% last year. The most frequent reported reason be infection was curiosity (35.5%). Correct observed...
We measured fungicidal activity of continuous infusion amphotericin B deoxycholate plus 5'flucytosine using quantitative cultures cerebrospinal fluid (CSF) obtained from lumbar punctures human immunodeficiency virus (HIV)-infected patients with neurocryptococcosis during 14 days treatment. Glomerular renal function was preserved in all patients. Mycological efficacy progressive reduction CSF cryptococcal colony-forming units comparable to standard 4-h B.
Background Currently, integrase inhibitors (INIs)-based ART regimens are the preferred initial therapy for AIDS patients. There is scarce information on use of dolutegravir (DTG) among late-presenter people living with HIV (PLHIV). Objectives To compare effect DTG- or efavirenz (EFV)-based outcomes patients advanced AIDS. Methods We compared two cohorts consecutive symptomatic (WHO stage 4, CD4 count&lt;50 cells/mL) starting DTG-based (2018–2021, prospective cohort) EFV-based (2013–2016,...
Abstract Objectives Regular quality-assured WGS with antimicrobial resistance (AMR) and epidemiological data of patients is imperative to elucidate the shifting gonorrhoea epidemiology, nationally internationally. We describe dynamics gonococcal population in 11 cities Brazil between 2017 2020 emerging disappearing lineages associated AMR, compare Brazilian AMR from 2015 2016, explain recent changes epidemiology. Methods was performed using Illumina NextSeq 550 genomes 623 isolates were used...
Abstract The epidemic caused by COVID-19 in Brazil is associated with an unfavorable political scenario, aggravated intense social inequality and low number of available hospital beds. Therefore, this study aimed to analyze the survival patients admitted Brazilian hospitals due estimate prognostic factors. This a retrospective, multicenter cohort study, based on data from 46285 hospitalizations for Brazil. Survival functions were calculated using Kaplan-Meier’s method. Log-rank test compared...
Hepatitis A virus (HAV) infection has disproportionately affected more men who have sex with (MSM), occurring in outbreaks, despite being vaccine-preventable. We determined the prevalence and factors associated HAV susceptibility among cisgender MSM on HIV pre-exposure prophylaxis (PrEP) Northeastern Brazil. From September 30, 2021 to June 19, 2023, 282 receiving PrEP were enrolled into this cross-sectional study. Sociodemographic clinical information collected. Blood samples collected for...
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This study aimed to determine the prevalence and factors associated with susceptibility hepatitis B virus (HBV) among cisgender men who have sex (MSM) on HIV pre-exposure prophylaxis (PrEP) in Northeastern Brazil.
Analisar o comportamento da tendência na utilização de testes rápidos sífilis, rede atenção básica em saúde das capitais brasileiras, no período 2019 a 2020. Trata-se um estudo ecológico, utilizando dados secundários do sistema nacional informações ambulatoriais. No janeiro dezembro 2020, foram calculadas as taxas padronizadas mensais por 100.000 habitantes, nas brasileiras. Para análise tendências, foi utilizado programa regressão Joinpoint, que através log-linear segmentada permite...
A Organização Mundial da Saúde estima que mais de 30 milhões pessoas no mundo estejam infectadas com o vírus imunodeficiência humana (HIV), e que, pelo menos um terço desta população, vive em áreas endêmicas leishmaniose.No Brasil, isso ocorre principalmente na região Nordeste. histoplasmose, 5 a 10% dos pacientes HIV+ pode evoluir para forma disseminada taxas mortalidade acima 50%. O objetivo deste trabalho é relatar caso paciente do Nordeste Brasileiro, co-infecção leishmaniose visceral...
A síndrome de reconstituição imune (SIRI) é uma resposta inflamatória anômala que ocorre em pacientes com HIV após iniciar a terapia antirretroviral (TARV). Manifesta-se através sintomas associados à reativação doenças prévias. Possui relevância clínica devido ao seu impacto na morbidade e mortalidade dos pacientes. Sua ocorrência está correlacionada alguns fatores risco o nosso paciente apresenta. Descrição: Relatamos quadro do sexo masculino, 41 anos, recebeu diagnóstico investigar...
A depressão é subdiagnosticada e subtratada em pessoas vivendo com HIV/Aids (PVHA). Considerando que fatores psicológicos têm um profundo impacto no tratamento da infecção pelo HIV, fato a influencia na disposição dos pacientes iniciar manter terapia antirretroviral (TARV), sendo preditor de resultados clínicos negativos. Por isso, o reconhecimento, monitoramento constante essencial para sucesso longo prazo TARV aumento qualidade vida HIV. O objetivo do estudo foi avaliar prevalência...