A5102838492- Angiogenesis and VEGF in Cancer
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Single-cell and spatial transcriptomics
- Protease and Inhibitor Mechanisms
- Blood Pressure and Hypertension Studies
- Congenital heart defects research
- Cerebrovascular and Carotid Artery Diseases
- Pregnancy and preeclampsia studies
- Cardiac Imaging and Diagnostics
- Cancer Genomics and Diagnostics
- Peripheral Artery Disease Management
- Pluripotent Stem Cells Research
- Vascular Procedures and Complications
- Apelin-related biomedical research
- Cardiac, Anesthesia and Surgical Outcomes
- Tuberous Sclerosis Complex Research
- Heart Failure Treatment and Management
- Adipose Tissue and Metabolism
- Kruppel-like factors research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Issues in Pregnancy
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Physical Activity and Health
- Renal and related cancers
Vanderbilt University
2020-2024
Gleneagles Hospital
2019-2024
Brown University
2023
Mayo Clinic
2023
Mayo Clinic Hospital
2023
Brigham and Women's Hospital
2023
Massachusetts General Hospital
2023
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2019
Rajasthan Dental College and Hospital
2017
Jaypee Institute of Information Technology
2017
Background— Neointimal vascular smooth muscle cell (VSMC) proliferation is a primary cause of occlusive disease, including atherosclerosis, restenosis after percutaneous interventions, and bypass graft stenosis. Angiogenesis implicated in the progression early atheromatous lesions animal models, but its role neointimal VSMC undefined. Because coronary interventions result induction periadventitial angiogenesis, we analyzed this process neointima formation. Methods Results— Local injury to...
Background— Placental growth factor (PlGF) has been implicated in the pathophysiological angiogenesis and monocyte recruitment that underlie chronic inflammatory disease, but its role atherosclerosis not examined. We investigated effects of exogenous PlGF, delivered by adenoviral gene transfer, on atherogenic intimal thickening macrophage accumulation induced collar placement around rabbit carotid artery examined PlGF deficiency apolipoprotein E–deficient (apoE −/− ) mice. Methods Results—...
Vascular injury initiates a cascade of phenotype-altering molecular events. Transcription factor function in this process, particularly that negative regulators, is poorly understood. We demonstrate here the forced expression injury-inducible GLI-Krüppel zinc finger protein Yin Yang-1 (YY1) inhibits neointima formation human, rabbit and rat blood vessels. YY1 p21 WAF1/Cip1 transcription, prevents assembly -cdk4-cyclin D1 complex, blocks downstream pRb Ser249/Thr252 phosphorylation PCNA...
Abstract Objectives : To construct a calculator to assess the risk of 30‐day mortality following PCI. Background Predictors are commonly used aid management decisions for cardiac surgical patients. There is need an equivalent risk‐score percutaneous coronary intervention (PCI) as many patients suitable both procedures. Methods The British Columbia Cardiac Registry (BCCR) population‐based registry that collects information on all PCI procedures performed in (BC). We data from BCCR identify...
The regulation of endothelial cell adhesion molecules (CAMs) by vascular growth factor (VEGF) was investigated in cultures and a rabbit model atherogenic neointima formation.VEGF CAM-1 (vascular molecule), intercellular (intercellular E-selectin were human umbilical vein cells using quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, flow cytometry, the collar macrophage accumulation immunostaining. VEGF alone caused no significant induction molecule-1, or compared...
Lipoprotein and apoiipoprotein parameters were studied in the male Zucker diabetic fatty (ZDF) rat at 10 20 weeks of age, corresponding to hyperinsulinemic insulinopenic type 2 diabetes mellitus, respectively.At both ages, ZDF rats had elevated serum triglycerides, free acids, corticosterone, whereas 20-week reduced thyroid hormones.At weeks, hyperlipidemia was confined elevations pre-13 triglyceride-rich (d < 1.006 g/mL) lipoproteins.By all lipoprotein density fractions increased compared...
Abstract The advent of high‐dimensional imaging offers new opportunities to molecularly characterize diagnostic cells in disorders that have previously relied on histopathological definitions. One example case is found tuberous sclerosis complex (TSC), a developmental disorder characterized by systemic growth benign tumors. Within resected brain tissues from patients with TSC, detection abnormally enlarged balloon (BCs) pathognomonic for this disorder. Though BCs can be identified an expert...
This study aims to determine the effects of periadventitial vascular endothelial growth factor (VEGF) gene transfer on neointima formation and macrophage accumulation induced by collar placement around carotid artery in hypercholesterolemic rabbits.Collar cholesterol-fed rabbits intimal thickening with increased neointimal content. Liposome-mediated VEGF transfer, confirmed transgene-specific RT-PCR, caused a marked inhibition both compared lacZ control gene. was not accompanied significant...
A 69‐year‐old man with chronic obstructive pulmonary disease (COPD) presented an exacerbation of cough and breathlessness, as well a 5 day history sudden‐onset bilateral calf tenderness. He had been commenced on inhaled steroids 4 1 / 2 years earlier then received maintenance oral prednisone. Upon examination, there was haematoma inferior to the medial malleolus no Achilles tenderness left side. On right side, focal over mid‐portion tendon pain accentuated upon dorsi flexion. venous duplex...
The present study aims to comparatively evaluate the isolation and quantification of stem cells derived from dental pulp periodontal ligament a permanent tooth assess their viability proliferation on platelet-rich fibrin (PRF) scaffold.
We report here the case of an infant who presented to emergency department after unintentional ingestion almost 130 mg/kg elemental iron. The had evidence serious toxicity in form hypotension, metabolic acidosis and excessive irritability. Her serum iron levels were 360 µg/dl, which was well above normal range for her age. Despite such high levels, made uneventful recovery with medical management alone did not require exchange transfusion. chose this highlight conservative therapy alone.
Cyclic immunohistochemistry (cycIHC) uses sequential rounds of colorimetric immunostaining and imaging for quantitative mapping location number cells interest. Additionally, cycIHC benefits from the speed simplicity brightfield microscopy, making collection entire tissue sections slides possible at a trivial cost compared to other high dimensional modalities. However, large datasets currently require an expert data scientist concatenate separate open-source tools each step image...
Vascular injury initiates a cascade of phenotype-altering molecular events. Transcription factor function in this process, particularly that negative regulators, is poorly understood. We demonstrate here the injury-inducible GLI-Krüppel zinc finger protein YY1 inhibits neointima formation human, rabbit and rat blood vessels. p21WAF1/Cip1 transcription, prevents assembly p21WAF1/Cip1-cdk4-cyclin D1 complex, blocks downstream pRbSer249/Thr252 phosphorylation expression PCNA TK-1. Conversely,...