A5089160902- Astrophysics and Cosmic Phenomena
- Dark Matter and Cosmic Phenomena
- Immunotherapy and Immune Responses
- Parasitic Infections and Diagnostics
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Toxoplasma gondii Research Studies
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Immune cells in cancer
- Particle Detector Development and Performance
- Advanced Semiconductor Detectors and Materials
- Semiconductor Quantum Structures and Devices
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- NF-κB Signaling Pathways
- Drug Transport and Resistance Mechanisms
- Ubiquitin and proteasome pathways
- Mineralogy and Gemology Studies
- CCD and CMOS Imaging Sensors
- Cultural Heritage Materials Analysis
- Immune Response and Inflammation
- Galaxies: Formation, Evolution, Phenomena
University of Pennsylvania
2023-2024
UPMC Hillman Cancer Center
2024
Cancer Research Institute
2024
Accademia di Belle Arti di Napoli
2024
South University
2023
California University of Pennsylvania
2023
University of Chicago Medical Center
2019
University of Chicago
2017-2018
The University of Texas MD Anderson Cancer Center
2017-2018
Foundation for the Advancement of Social Theory
2017
Abstract Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable clinical success in the treatment of hematological malignancies. However, producing these bespoke cancer‐killing cells is a complicated ex vivo process involving leukapheresis, artificial activation, and CAR construct introduction. The activation step requires engagement CD3/TCR CD28 vital for transfection differentiation. Though antigen‐presenting (APCs) facilitate vivo, relies on antibodies against CD3...
Lipid nanoparticles (LNPs) have emerged as a viable, clinically-validated platform for the delivery of mRNA therapeutics. LNPs been utilized systems applications including vaccines, gene therapy, and cancer immunotherapy. However, LNPs, which are typically composed ionizable lipids, cholesterol, helper lipid-anchored polyethylene glycol, often traffic to liver limits therapeutic potential platform. Several approaches proposed resolve this tropism such post-synthesis surface modification or...
Acquired resistance to immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using mouse model of pancreatic ductal adenocarcinoma (PDAC) study tumor relapse following immunotherapy-induced responses, we find that is reproducibly associated with an epithelial-to-mesenchymal transition (EMT), EMT-transcription factors ZEB1 and SNAIL functioning as master genetic epigenetic regulators this effect. in not due immunosuppression the immune microenvironment,...
Cryptosporidium causes debilitating diarrheal disease in patients with primary and acquired defects T cell function. However, it has been a challenge to understand how this infection generates responses they mediate parasite control. Here, was engineered express effector protein (MEDLE-2) that contains the major histocompatibility complex-I restricted SIINFEKL epitope which is recognized by receptor transgenic OT-I(OVA-TCR-I) clusters of differentiation (CD)8+ cells. These modified parasites...
The Fluorescence detector Array of Single-pixel Telescopes is a proposed low-cost, large-area, next-generation experiment for the detection ultrahigh-energy cosmic rays via atmospheric fluorescence technique. design involves deployment several hundred large field-of-view telescopes on regular grid thousand square kilometers in ground area. This paper describes optical prototype telescope, as well its mechanical support structure.
Contributions of the Fluorescence detector Array Single-pixel Telescopes (FAST) to 35th International Cosmic Ray Conference, 12-20 July 2017, Busan, Korea
Abstract Cryptosporidium causes debilitating diarrheal disease in patients with primary and acquired defects T cell function. However, it has been a challenge to understand how this infection generates responses they mediate parasite control. Here, was engineered express effector protein (MEDLE-2) that contains the MHC-I restricted SIINFEKL epitope which is recognized by TCR transgenic OT-I CD8 + cells. These modified parasites induced expansion of endogenous SIINFEKL-specific cells were...
Cryptosporidium is an enteric pathogen and a prominent cause of diarrheal disease worldwide. Control requires CD4+ T cells, but how protective cell responses are generated poorly understood. Here, parasites that express MHCII-restricted model antigens were to understand the basis for priming effector function. These studies revealed parasite-specific cells primed in draining mesenteric lymph node differentiate into Th1 gut provide local parasite control. Although type 1 conventional...
Abstract Acquired resistance to immune checkpoint immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using mouse model of pancreatic ductal adenocarcinoma (PDAC) study tumor relapse following immunotherapy-induced responses, we found that tumors underwent an epithelial-to-mesenchymal transition (EMT) resulted in reduced sensitivity T cell-mediated killing. EMT-transcription factors (EMT-TFs) ZEB1 and SNAIL function as master genetic epigenetic regulators...
Abstract Cryptosporidium is an enteric pathogen that a prominent cause of diarrheal disease. Control this infection requires CD4 + T cells, though the processes lead to cell-mediated resistance have been difficult assess. Here, parasites express MHCII-restricted model antigens were generated dissect early events influence cell priming and effector function. These studies highlight parasite-specific cells are primed in draining mesenteric lymph node (mesLN) differentiate into Th1 gut, where...
We present the opto-mechanical design of a new generation fluorescence telescope for de- tection ultrahigh-energy cosmic rays (UHECRs). The Fluorescence detector Array Single- pixel Telescopes (FAST) is proposed low-cost, large-area, next-generation experiment detection UHECRs via atmospheric technique. simpli- fied Schmidt design, suitable camera consisting only few large pixels. has 1 m2 entrance aperture, and field-of-view 30◦ × . optical prototype as well mirror alignment pointing...
The results of non-invasive diagnostic analyses the painting Adoration Magi by Artemisia Gentileschi are presented. It was created in 1630s to decorate choir Cathedral San Procolo Pozzuoli (Naples, Italy). Multispectral imaging at different wavelengths (VIS, IR and UV) X-ray fluorescence (XRF) were used. data integrated compared with art historical literature on Artemisia's activity, especially Naples after 1630. research aims identify artist's palette, materials used, including restoration,...
The Fluorescence detector Array of Single-pixel Telescopes (FAST) is a design concept for the next generation ultrahigh-energy cosmic ray (UHECR) observatories, addressing requirements large-area, low-cost suitable measuring properties highest en- ergy rays. In FAST design, large field view covered by few pixels at focal plane mirror or Fresnel lens. Motivated successful detection UHECRs using prototype comprised single 200 mm photomultiplier-tube and 1 m^2 lens system [Astropart.Phys. 74...
<h3>Background</h3> Adaptive immunity is driven by antigen-restricted cell:cell interactions. In mice, two-photon excitation microscopy (TPEM) has revolutionized our understanding of immune cell architectures. However, TPEM several limitations: most notably it can only be used to study manipulated animal model systems and not human disease. Previously, we demonstrated that quantifying the distance between B cells T in multichannel confocal images tissue (Cell Distance Mapping, CDM) could...