A5051516944- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Biochemical effects in animals
- Polyamine Metabolism and Applications
- Cannabis and Cannabinoid Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Autophagy in Disease and Therapy
- Systemic Lupus Erythematosus Research
- Diet, Metabolism, and Disease
- Epigenetics and DNA Methylation
- Moringa oleifera research and applications
Universitat de Barcelona
2015-2021
Centre for Biomedical Network Research on Rare Diseases
2021
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2021
Hospital Clínic de Barcelona
2015-2018
Centro de Investigación Biomédica en Red
2018
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2015
Chiba University
2015
University College London
2015
Ocera Therapeutics (United States)
2015
Grifols (United States)
2015
Background & AimsCirrhosis and its clinical consequences can be aggravated by bacterial infections, ultimately leading to the development of acute on chronic liver failure (ACLF), characterized decompensation, organ failure, high mortality within 28 days. Little is known about cellular molecular mechanisms ACLF in patients with cirrhosis, so no therapeutic options are available. We developed a sepsis-associated preclinical model facilitate studies pathogenesis evaluate protective effects...
In cirrhosis, increased intrahepatic vascular resistance (IHVR) is the primary factor for portal hypertension (PH) development. Hepatic stellate cells (HSCs) play a major role increasing IHVR because, when activated, they are contractile and promote fibrogenesis. Protease‐activated receptors (PARs) can activate HSCs through thrombin Xa, which known PAR agonists, cause microthrombosis in liver microcirculation. This study investigates effects of oral anticoagulant, rivaroxaban (RVXB), direct...
Abstract Background & Aims In cirrhosis, activated hepatic stellate cells ( HSC ) play a major role in increasing intrahepatic vascular resistance and developing portal hypertension. We have shown that cirrhotic livers increased reactive oxygen species ROS ), antioxidant therapy decreases pressure. Considering mitochondria produce many of these , our aim was to assess the effects oral mitochondria‐targeted mitoquinone on oxidative stress, phenotype, liver fibrosis Methods Ex vivo:...
Advanced chronic liver disease (aCLD) represents a major public health concern. aCLD is more prevalent and severe in the elderly, carrying higher risk of decompensation. We aimed at understanding how aging may impact on pathophysiology aged rats humans secondly, evaluating simvastatin as therapeutic option animals. was induced young (1 month) old (16 months) rats. A subgroup aCLD-old animals received (5 mg/kg) or vehicle (PBS) for 15 days. Hepatic systemic hemodynamic, cells phenotype...
Increased hepatic vascular resistance is the primary factor in development of portal hypertension. Metformin ameliorates cells function several beds. Our study was aimed at evaluating effects, and underlying mechanisms, metformin on systemic hemodynamics cirrhotic rats its possible interaction with effects propranolol (Prop), current standard treatment for CCl 4 -cirrhotic received by gavage 300 mg/kg or vehicle once a day 1 wk, before mean arterial pressure (MAP), (PP), blood flow (PBF),...
Porto-sinusoidal vascular disease (PSVD) is a rare that requires excluding cirrhosis and other causes of portal hypertension for its diagnosis because it lacks specific diagnostical test. Although has been occasionally associated with autoimmune diseases, the pathophysiology PSVD remains unknown. The aim this study was to evaluate potential role autoimmunity in PSVD.Thirty-seven consecutive patients 39 matched by gender, signs liver function were included (training set). By using Indirect...
Chronic liver diseases are multifactorial and the need to develop effective therapies is high. Recent studies have shown potential of ameliorating disease progression through protection endothelium. Polyamine spermidine (SPD) a caloric restriction mimetic with autophagy-enhancing properties capable prolonging lifespan proven beneficial effect in cardiovascular mice humans. We evaluated use dietary supplementation SPD two models (CCl4 CDAAH diet). analyzed on endothelial dysfunction vitro...
We have developed two advanced cirrhosis regression experimental models with persistent relevant fibrosis and portal hypertension an associated deteriorated metabolism that mimic what happens in patients. LI, despite improving metabolism, did not enhance the process our cirrhotic models. CR further reduce PP, hepatic fibrosis, or HSC activation. MEE exhibited a profibrogenic effect liver blunting regression. One of potential explanations this worsening could be ammonia accumulation.