A5043545403- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Venous Thromboembolism Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Electrolyte and hormonal disorders
- Alcohol Consumption and Health Effects
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
- Cardiac, Anesthesia and Surgical Outcomes
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Drug-Induced Hepatotoxicity and Protection
- Abdominal vascular conditions and treatments
- Atrial Fibrillation Management and Outcomes
- Hemodynamic Monitoring and Therapy
- Systemic Lupus Erythematosus Research
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- Clinical practice guidelines implementation
- COVID-19 Clinical Research Studies
- Central Venous Catheters and Hemodialysis
Universitat de Barcelona
2020-2024
Centre for Biomedical Network Research on Rare Diseases
2021-2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2021-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2020-2024
Fundació Clínic per a la Recerca Biomèdica
2024
Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
2024
Hospital Clínic de Barcelona
2021-2023
Agència de Gestió d'Ajuts Universitaris i de Recerca
2023
ERN GUARD-Heart
2023
Centro de Investigación Biomédica en Red
2023
•Factors related to more severe portal hypertension are associated with higher risk of PVT in cirrhosis.•Acquired and inherited alterations coagulation do not predict development during follow-up.•Cirrhosis-associated inflammation or generation NETs relevant factors predicting development. Background & AimsPortal vein thrombosis (PVT) is a relatively frequent event patients cirrhosis. While different for have been reported, such as decreased blood flow velocity (PBFV) parameters severity...
•Around 9% of patients with alcohol-related cirrhosis are delisted for improvement.•MELD score is the main determinant improvement.•Women have higher probabilities being improvement.•Outcomes after delisting globally favorable and affected by alcohol relapse. Background & AimsTo what extent decompensated can improve until recovery from decompensation remains unclear. We aimed to investigate probability due improvement in on waiting list (WL) liver transplantation (LT).MethodsWe conducted a...
Background and Aims: Patients with compensated cirrhosis clinically significant portal hypertension (CSPH: HVPG > 10 mm Hg) have a high risk of decompensation. is, however, an invasive procedure not available in all centers. The present study aims to assess whether metabolomics can improve the capacity clinical models predicting outcomes these patients. Approach Results: This is nested from PREDESCI cohort (an RCT nonselective beta-blockers vs. placebo 201 patients CSPH), including 167...
•Patients with PSVD have a unique transcriptomic profile.•Pathways related to vascular homeostasis might be involved in development.•Intravascular endothelial dysfunction is key pathophysiology.•Maintaining healthy liver endothelium emerges as promising therapeutic strategy. Background & AimsPorto-sinusoidal disease (PSVD) rare of unknown etiology that causes portal hypertension. It usually affects young individuals and shortens live expectancy. The deregulated pathways development are...
Porto-sinusoidal vascular disease (PSVD) is a rare that requires excluding cirrhosis and other causes of portal hypertension for its diagnosis because it lacks specific diagnostical test. Although has been occasionally associated with autoimmune diseases, the pathophysiology PSVD remains unknown. The aim this study was to evaluate potential role autoimmunity in PSVD.Thirty-seven consecutive patients 39 matched by gender, signs liver function were included (training set). By using Indirect...
Abstract Background and Aims A reduction in hepatic venous pressure gradient (HVPG) is the most accurate marker for assessing severity of portal hypertension effectiveness intervention treatments. This study aimed to evaluate prognostic potential blood‐based proteomic biomarkers predicting HVPG response amongst cirrhotic patients with due Hepatitis C virus (HCV) had achieved sustained virologic (SVR). Methods The comprised 59 from two cohorts. Patients underwent paired (pretreatment after...
Background & AimsEtiologic factor removal (ER) drives recompensation and improves portal hypertension in cirrhosis. Esophageal varices (EV) portosystemic shunts (PSS) have been found patients despite hepatic vein pressure gradient (HVPG) dropping below 10mmHg after ER, questioning HVPG accuracy reflecting true the setting of ER. We aim to evaluate correlation with direct (DPP) persistence EV ER < 10mmHg.MethodsBicentric "proof concept" study evaluating ultrasound guided percutaneous DPP HCV...
Porto-sinusoidal vascular disorder (PSVD) encompasses a group of liver diseases with abnormalities that can cause portal hypertension in the absence cirrhosis. The new diagnostic criteria allow for coexistence other diseases, however its relationship chronic hepatitis B (CHB) remains unclear. This study aimed to assess HBV prevalence PSVD cohort and evaluate clinical impact.
Abstract Background & Aims Sustained virological response (SVR) to direct‐acting antivirals ameliorates portal hypertension, improves hepatic function and may reverse the procoagulant state observed in patients with cirrhosis. However, an unexpected incidence of vein thrombosis (PVT) immediately after antiviral therapy has recently been reported. Therefore, we analysed long‐term impact SVR on development non‐tumoural PVT. Methods Our study comprised two well‐characterized prospective...
Patients with vascular liver diseases (VLD) are at higher risk of both severe courses COVID-19 disease and thromboembolic events. The impact SARS-CoV-2 vaccination in patients VLD has not been described represents the aim our study. International, multicenter, prospective observational study analyzing incidence infection after vaccination, severity side effects, occurrence events hepatic decompensation. In a subgroup patients, humoral cellular responses to were also analyzed. A total 898...