A5008842666- Developmental Biology and Gene Regulation
- Genetic Neurodegenerative Diseases
- Congenital heart defects research
- Wnt/β-catenin signaling in development and cancer
- Neuroscience and Neuropharmacology Research
- Muscle Physiology and Disorders
- Hedgehog Signaling Pathway Studies
- Congenital gastrointestinal and neural anomalies
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- melanin and skin pigmentation
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Zebrafish Biomedical Research Applications
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Retinal Development and Disorders
- Cancer-related gene regulation
- Congenital Ear and Nasal Anomalies
- Biochemical Analysis and Sensing Techniques
- Silk-based biomaterials and applications
- Kruppel-like factors research
- ATP Synthase and ATPases Research
- Axon Guidance and Neuronal Signaling
- Congenital limb and hand anomalies
Centre National de la Recherche Scientifique
2011-2024
Université Paris-Saclay
2017-2024
Institut des Neurosciences Paris-Saclay
2024
Inserm
2011-2023
Université Paris Sciences et Lettres
2017-2023
Institut Curie
2009-2023
Grenoble Institute of Neurosciences
2022
Université Grenoble Alpes
2022
Centre Hospitalier Universitaire de Grenoble
2022
Université Paris-Sud
2011-2015
The therapeutic activity of selective serotonin (5-HT) reuptake inhibitors (SSRIs) relies on long-term adaptation at pre- and post-synaptic levels. sustained administration SSRIs increases the serotonergic neurotransmission in response to a functional desensitization inhibitory 5-HT1A autoreceptor dorsal raphe. At nerve terminal such as hippocampus, enhancement 5-HT availability brain-derived neurotrophic factor (BDNF) synthesis signaling, major event stimulation adult neurogenesis. In...
Huntingtin (HTT), the protein mutated in Huntington's disease (HD), controls transport of neurotrophin, brain-derived neurotrophic factor (BDNF), within corticostriatal neurons. Transport and delivery BDNF to striatum are reduced disease, which contributes striatal neuron degeneration. released by cortical neurons activates TrkB receptors at dendrites promote survival. However, it remains be determined whether TrkB, receptor, depends on HTT such is altered mutant situation. Here we show that...
Insm1 (IA-1) encodes a Zn-finger factor that is expressed in the developing nervous system. We demonstrate here development of sympatho-adrenal lineage severely impaired mutant mice. Differentiation precursors, as assessed by expression neuronal subtype-specific genes such Th and Dbh, delayed pronounced manner, which accompanied reduced proliferation. Sympathetic neurons eventually overcome differentiation blockade mature correctly, but sympathetic ganglia remain small. By contrast, terminal...
Neurotrophin-bearing endosomes respond to local calcium concentrations self-direct long-range retrograde transport.
Summary Endothelin receptors B (Ednrb) are involved in the development of enteric and melanocytic lineages, which originate from neural crest cells (NCCs). In mice, trunk NCCs their derivatives express only one Ednrb. quail, two Ednrb: Ednrb Ednrb2. Quail is expressed migrating along ventral pathway, gives rise to peripheral nervous system, including ganglia. Ednrb2 upregulated before these enter dorsolateral pathway. The pathway melanocyte precursors. We analyzed vitro differentiation ovo...
Monoaminergic neurons include the physiologically important central serotonergic and noradrenergic subtypes. Here, we identify zinc-finger transcription factor, Insm1, as a crucial mediator of differentiation both subtypes, in particular acquisition their neurotransmitter phenotype. Insm1 is expressed hindbrain progenitors monoaminergic they exit cell cycle, pattern that partially overlaps with expression proneural factor Ascl1. Consistent this, conserved cis-regulatory sequence associated...
Huntington disease (HD) is associated with early psychiatric symptoms including anxiety and depression. Here, we demonstrate that wild-type huntingtin, the protein mutated in HD, modulates anxiety/depression-related behaviors according to its phosphorylation at serines 1181 1201. Genetic phospho-ablation 1201 mouse reduces basal levels of anxiety/depression-like behaviors. We observe reduction phenotypes increased adult hippocampal neurogenesis. By improving attachment molecular motors...
Pax3 is a member of the paired-box-containing transcription factors. It expressed in developing somites, dorsal spinal cord, mesencephalon and neural crest derivatives. Several loss-of-function mutations are correlated with Splotch phenotype mice Waardenburg syndrome humans. Malformations include lack muscle limb, failure tube closure dysgenesis numerous In this study we have used embryonic stem (ES) cells to generate lacZ knock-in into locus. The allele (Sp(2G)) was Pax3-deficient ES order...
Neural crest (NC) specification comprises an early phase, initiating immature NC progenitors formation at neural plate stage, and a later phase fold resulting into functional premigratory NC, able to delaminate migrate. We found that the Gene Regulatory Network triggers up-regulation of pfkfb4 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4) during this late phase. As shown in previous studies, PFKFB4 controls AKT signaling gastrulas glycolysis rate adult cells. Here, we focus on...
Huntington's disease (HD) is a fatal neurodegenerative disease, characterized by motor defects and psychiatric symptoms, including mood disorders such as anxiety depression. HD caused an abnormal polyglutamine (polyQ) expansion in the huntingtin (HTT) protein. The development analysis of various mouse models that express pathogenic polyQ-HTT revealed link between mutant HTT anxio-depressive behaviors hippocampal neurogenesis defects. However, it unclear whether phenotype linked to alteration...
Embryonic stem (ES) cells differentiate into various cell lineages in vitro. A procedure was previously designed to promote the differentiation of ES towards melanocyte lineage and obtain large reproducible amounts melanocytes. To elucidate main events that lead development melanocytes vitro, we used transgenic Dct::lacZ mouse blastocysts establish lines expressing lacZ reporter gene under control Dct promoter. Dct, a melanoblast marker, is expressed just after determination vivo. We...
Branchiomotor neurons comprise an important class of cranial motor that innervate the branchial-arch-derived muscles face, jaw and neck. They arise in ventralmost progenitor domain rhombencephalon characterized by expression homeodomain transcription factors Nkx2.2 Phox2b. Phox2b particular plays a key role specification branchiomotor neurons. In its absence, generic neuronal differentiation is defective no are produced. Conversely, ectopic spinal regions neural tube promotes cell cycle exit...
Summary statement PFKFB4 controls neural crest final specification and migration by regulation of AKT signaling or glycolysis. Abstract Neural (NC) comprises an early phase, initiating immature NC progenitors formation at plate stage, a later phase fold resulting into functional premigratory NC, able to delaminate migrate. We found that the NC-GRN triggers up-regulation pfkfb4 (6- p hosphofructo-2- k inase/ f ructose-2,6- b isphosphatase 4 ) during this late phase. As shown in previous...
Unlike mammals, some nonmammalian species recruit Müller glia for retinal regeneration after injury. Identifying the underlying mechanisms may help to foresee regenerative medicine strategies. Using a