A5033947768- Pharmacological Receptor Mechanisms and Effects
- Substance Abuse Treatment and Outcomes
- Atrial Fibrillation Management and Outcomes
- Alcohol Consumption and Health Effects
- Forensic Toxicology and Drug Analysis
- Medical Image Segmentation Techniques
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Acute Ischemic Stroke Management
- Peripheral Artery Disease Management
- Air Quality and Health Impacts
- Gastrointestinal disorders and treatments
- Neuroscience and Neuropharmacology Research
- ECG Monitoring and Analysis
- Gastrointestinal motility and disorders
- Opioid Use Disorder Treatment
- COVID-19 epidemiological studies
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Air Quality Monitoring and Forecasting
- Intestinal Malrotation and Obstruction Disorders
- Cardiac Arrhythmias and Treatments
- Vaccine Coverage and Hesitancy
- Cardiac Imaging and Diagnostics
Louisiana State University Health Sciences Center Shreveport
2021-2025
Louisiana State University
2022-2024
Louisiana State University in Shreveport
2022-2024
Saidu Teaching Hospital
2024
Thomas Jefferson University
2024
Thomas Jefferson University Hospital
2024
University of Swat
2024
Jefferson Hospital
2024
University of Tabriz
2023
Universidad de Guadalajara
2023
Abstract Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular dysfunction, and also induce late-onset cardiomyopathy heart failure. Despite extensive studies, the pathogenic sequelae leading to progression of Dox-associated remains unknown. We assessed temporal changes in autophagy, mitochondrial dynamics, bioenergetics mouse models chronic Dox-cardiomyopathy. Time course study Dox-treatment showed accumulation LC3B II lysates. Autophagy flux assays confirmed...
Abstract Background Recent single-center reports have suggested that community-acquired bacteremic co-infection in the context of Coronavirus disease 2019 (COVID-19) may be an important driver mortality; however, these not been validated with a multicenter, demographically diverse, cohort study data spanning pandemic. Methods In this retrospective study, inpatient encounters were assessed for COVID-19 using 48-h post-admission blood cultures and grouped by: (1) confirmed [recovery bacterial...
Lactate is used as an energy source by producer cells or shuttled to neighboring and tissues. Both glucose lactate fulfill the bioenergetic demand of neurons, latter imported from astrocytes. The contribution astrocytic neuronal bioenergetics mechanisms production are incompletely understood. Through in vivo 1H magnetic resonance spectroscopy, 13C mass electroencephalographic molecular studies, here we show that sensor AMP activated protein kinase (AMPK) regulates survival a...
Alzheimer's disease (AD), a neurodegenerative that mostly affects the elderly, slowly impairs memory, cognition, and daily tasks. AD has long been one of most debilitating chronic neurological disorders, affecting people over 65. In this study, we investigated use Vision Transformer (ViT) for Magnetic Resonance Image processing in context diagnosis. ViT was utilized to extract features from MRIs, map them feature sequence, perform sequence modeling maintain interdependencies, classify using...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an umbrella term for simple hepatic steatosis and the more severe metabolic steatohepatitis. The current reliance on biopsy diagnosis a lack of validated biomarkers are major factors contributing to overall burden MASLD. This study investigates association between stiffness measurements, measured by FibroScan®. Data from National Health Nutritional Examination Survey (2017-2020) was collected 15,560 patients. Propensity...
Background The Sigma 1 receptor (Sigmar1) functions as an interorganelle signaling molecule and elicits cytoprotective functions. presence of Sigmar1 in the heart was first reported on basis a ligand-binding assay, all studies to date have been limited pharmacological approaches using less-selective ligands for Sigmar1. However, physiological function cardiac remains unknown. We investigated regulating hemodynamics knockout mouse (Sigmar1-/-). Methods Results Sigmar1-/- hearts at 3 4 months...
Abstract Methamphetamine-associated cardiomyopathy is the leading cause of death linked with illicit drug use. Here we show that Sigmar1 a therapeutic target for methamphetamine-associated and defined molecular mechanisms using autopsy samples human hearts, mouse model “binge crash” methamphetamine administration. expression significantly decreased in hearts users those methamphetamine-treated mice. The also signs cardiomyopathy, including cellular injury, fibrosis, enlargement heart. In...
Methamphetamine is an emerging drug threat. The disparity in cardiomyopathy-associated hospital admissions among methamphetamine users (CAHMA) over the decade remains unknown. purpose of this study was to determine trends and prevalence CAHMA by age, sex, race, geographical region. We used data from 2008 2020 National Inpatient Sample database. identified 12,845,919 admissions; them, 222,727 were diagnosed as users. A generalized linear model with binomial link function compute ratio 95% CI....
Emerging evidence indicates that vascular stress is an important contributor to the pathophysiology of Alzheimer's disease and related dementias (ADRD). Hydrogen sulfide (H2S) its metabolites (acid-labile (e.g., iron-sulfur clusters) bound per-, poly-) sulfides) have been shown modulate both neuronal homeostasis. We recently reported elevated plasma sulfides were associated with cognitive dysfunction measures microvascular in ADRD. Here we extend our previous work show associations between...
Abstract One of the highly focused areas in medical science community is segmenting tumors from brain magnetic resonance imaging (MRI). The diagnosis malignant at an early stage necessary to provide treatment for patients. patient’s prognosis will improve if it detected early. Medical experts use a manual method segmentation when making tumors. This study proposes new approach simplify and automate this process. In recent research, multi-level has been widely used image analysis,...
Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide, necessitating early and accurate diagnosis for optimal patient management. In recent years, advancements in deep learning have shown remarkable potential medical image analysis. Methods this study, we present "ViTranZheimer," an AD approach which leverages video vision transformers to analyze 3D brain MRI data. By treating the volumes as videos, exploit temporal dependencies between slices capture...
The progression of Alzheimer's disease (AD), a leading cause dementia worldwide, is known for its variability and complexity, challenging the conventional methods monitoring predicting trajectories. This study introduces semiparametric modeling approach to analyze longitudinal cognitive imaging data. We studied two different outcome variables from Disease Neuroimaging Initiative (ADNI) database: Assessment Scale-Cognitive Subscale 13 (ADAS13) scores ventricular volumes [Formula: see text]....
Introduction Whole blood viscosity (WBV), reflecting the intrinsic resistance of flow, is an established predictor stroke events in individuals. This study aims to correlate WBV at different shear rates with outcome mechanical thrombectomy, known be effective treatment for large vessel occlusion (LVO) stroke. Method a single-center retrospective conducted our comprehensive center. The charts 317 patients who underwent thrombectomy within 6 h LVO presentation were reviewed. modified Rankin...
The decision for tracheostomy bronchopulmonary dysplasia (BPD) is highly variable and often dictated by local practice. We aimed to characterize morbidity, mortality, respiratory outcomes in preterm infants undergoing severe BPD.We retrospectively reviewed a single-center 4-year cohort of all born <33 weeks gestational age (GA) that required due BPD. Indications apart from BPD were excluded. Demographic information, comorbidities, management, at tracheostomy, post-discharge outcomes,...
We examined COVID-19 concerns, vaccine acceptance, and trusted sources of information among patients in a safety-net health system Louisiana. The participants were surveyed via structured telephone interviews over nine months 2021. Of 204 adult participants, 65% female, 52% Black, 44.6% White, 46.5% rural residents. mean age was 53 years. viewed as serious public threat (8.6 on 10-point scale). Black adults more likely to perceive the virus than White (9.4 vs. 7.6 p < 0.0001), urban...
Widespread concern has been expressed regarding unrealistic body image and adolescent eating disorder promoting content on social media (SM) platforms. Numerous research studies have examined the impact of SM as well vulnerability negative mental health outcomes. Despite this, few previous specifically in vulnerable, underserved, or predominantly minority communities. This study examines issues (BII) adolescents a public school system where greater than 50% students live impoverished...
Abstract Introduction Cannabidiol (CBD) is a potential therapeutic for pain management. Yet, there exists dearth of studies its tolerability and efficacy, especially in special populations. Former elite athletes are population both susceptible to chronic also highly trained attuned assess medication concerns. The purpose the present open-label pilot study was CBD this population. Materials methods Retrospective analysis conducted deidentified data from 20 individuals who were all previously...
Atrial fibrillation (AF) is the most common arrhythmia in patients with cancer, especially breast, gastrointestinal, respiratory, urinary tract, and hematological malignancies. Catheter ablation (CA) a well-established, safe treatment option healthy patients; however, literature regarding safety of CA for AF cancer limited confined to single centers. We aimed assess outcomes peri-procedural certain types cancer. The NIS database was queried between 2016 2019 identify primary hospitalizations...
Alzheimer's Disease (AD) is a progressive neurodegenerative disease caused by the deposition of Aβ aggregates or neurofibrillary tangles. AD patients are primarily diagnosed with concurrent development several cardiovascular dysfunctions. While few studies have indicated presence intramyocardial aggregates, none performed detailed analyses for pathomechanism cardiac dysfunction in patients. This manuscript used aged APPSWE/PS1 Tg and littermate age-matched wildtype (Wt) mice to characterize...
ABSTRACT Background and Objectives: Nonalcoholic fatty liver disease (NAFLD) is linked to obesity. Obesity associated with lower socioeconomic status (SES). An independent link between pediatric NAFLD SES has not been elucidated. The objective of this study was evaluate the distribution deprivation, measured using an area‐level proxy, in patients known determine whether deprivation severity. Methods: Retrospective <21 years NAFLD, followed from 2009 2018. patients’ addresses were mapped...
The illicit use of methamphetamine (MA), a dangerous psychostimulant has become global epidemic. Studies have demonstrated link between substance and cardiovascular consequences. objective this study was to assess whether MA is associated with an early onset diseases (CVD).Retrospective analysis conducted using data collected from 1376 individuals at Louisiana State University Health Sciences Center - Shreveport 2011 2020. Cardiovascular patients without history were divided into the Control...
The recent rise in illicit use of methamphetamine (METH), a highly addictive psychostimulant, is huge health care burden due to its central and peripheral toxic effects. Mounting clinical studies have noted that METH humans associated with the development cardiomyopathy; however, preclinical animal models dissect detailed molecular mechanisms METH-associated cardiomyopathy are scarce. present study utilized unique very long-access binge crash procedure self-administration characterize...
An arrhythmia, also known as a dysrhythmia, refers to an irregular heartbeat. There are various types of arrhythmias that can originate from different areas the heart, resulting in either rapid, slow, or electrocardiogram (ECG) is vital diagnostic tool used detect heart irregularities and abnormalities, allowing experts analyze heart's electrical signals identify intricate patterns deviations norm. Over past few decades, numerous studies have been conducted develop automated methods for...