A5070217159- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Cerebrospinal fluid and hydrocephalus
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Glioma Diagnosis and Treatment
- S100 Proteins and Annexins
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Alcoholism and Thiamine Deficiency
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Radiopharmaceutical Chemistry and Applications
- Schizophrenia research and treatment
- Neurological Disease Mechanisms and Treatments
- Neurological and metabolic disorders
- Neurotransmitter Receptor Influence on Behavior
- Musculoskeletal pain and rehabilitation
- Electroconvulsive Therapy Studies
- Substance Abuse Treatment and Outcomes
NHS Lanarkshire
2025
Louisiana State University Health Sciences Center Shreveport
2007-2024
Louisiana State University
2003-2023
Louisiana State University in Shreveport
2021-2023
Louisiana Cancer Research Center
2022
Louisiana State University Health Sciences Center New Orleans
2010-2021
Pfizer (United States)
1998-2021
University of Alabama at Birmingham
2006-2015
Southern General Hospital
1997-2013
University of Glasgow
1984-2012
✓ Patients with severe head injury frequently have evidence of elevated intracranial pressure (ICP) and ischemic neuronal damage at autopsy. Mannitol has been used clinically to reduce ICP varying success, it is possible that more effective in some types than others. The aim the present study was determine effect mannitol on ICP, cerebral perfusion (CPP), blood flow (CBF) patients injury, discover if these effects differed different injury. Measurements CPP, CBF were made 55 In general,...
Single photon emission computed tomography (SPECT) used in conjunction with HM-PAO (Ceretec-Amersham International) was to image regional cerebral blood flow (rCBF) 28 patients medically intractable complex partial seizures during or soon after a seizure, and interictally. Changes from interictal rCBF were seen 26/28 (93%) patients. The main findings were; 1) During the seizure--hyperperfusion of whole temporal lobe; 2) Up 2m postically--hyperperfusion hippocampus hypoperfusion lateral...
Abstract While heart disease remains a common cause of mortality, cerebrovascular also increases with age, and has been implicated in Alzheimer's related dementias (ADRD). We have described hydrogen sulfide (H 2 S), signaling molecule important vascular homeostasis, as biomarker cardiovascular disease. hypothesize that plasma H S its metabolites relate to cognitive dysfunction ADRD. used analytical biochemical methods measure MRI evaluate indicators microvascular Levels total specific were...
Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to image 26 patients dementia of the Alzheimer type (DAT) and 10 healthy controls. Regional cerebral blood flow (rCBF) data indicated a relative sparing occipital regions in DAT. Normalisation illustrated highly significant CBF deficits number cortical regions, particularly left right posterior--temporal cortex DAT compared The cognitive performance measured using clinical assessment procedure (CAMCOG) numerous...
Resting cerebral blood flow (CBF) and the response to inhalation of 7 per cent CO2 was measured in 74 patients with symptoms cerebrovascular disease. In order evaluate their role identification significant arterial lesions, these measurements were correlated angiographic appearances, clinical picture presence or absence infarction on CT scan. Patients carotid stenosis 60 more had normal resting flows, but reduced responsiveness inhalation. occlusion both responsiveness. Infarcts visible 25...
SYNOPSIS Single photon emission tomography (SPET) with the lipophilic blood flow marker 99m Tc-hexamethyl propyleneamine oxime ( Tc-HMPAO) has been used to determine regional uptake of radiolabel into brain regions patients presenile Alzheimer's disease and Korsakoff's psychosis, age-matched controls. Using occipital cortical as reference area, pattern relative cerebral (rCBF) was determined in other areas basal ganglia. In disease, reduction rCBF occurred most strikingly posterior temporal...
Image non-uniformity in magnetic resonance imaging (MRI) is a recognised problem when using surface coils but rarely mentioned with respect to standard head coils, yet it can be source of error clinical interpretation images. Figure 1 demonstrates the type artefacts due image for large, homogeneous solution water and copper sulphate. The was acquired coronal section coil, vertical (i.e. read direction) horizontal phase encode pixel intensity profiles through centre are illustrated. deviation...
The response of cerebral blood flow (CBF) to drug-induced hypotension was measured in 20 patients who underwent craniotomy for clipping a aneurysm following subarachnoid hemorrhage. A modified intravenous xenon-133 injection technique used monitor CBF. In 15 patients, CBF increased significantly with hypotension, and only one developed late neurological deficit. five fell halothane-induced four delayed deficits. Measurement the intraoperative may reveal those at greatest risk developing...
Abstract The use of cytokines for immunotherapy shows clinical efficacy but is frequently accompanied by severe adverse events caused excessive and systemic immune activation. Here, we set out to address these challenges engineering a fusion protein single, potency-reduced, IL15 mutein PD1-specific antibody (anti-PD1-IL15m). This immunocytokine was designed deliver PD1-mediated, avidity-driven IL2/15 receptor stimulation PD1+ tumor-infiltrating lymphocytes (TIL) while minimally affecting...
The aggregation of Aβ-peptide (Aβ) is widely considered to be the critical step in pathology Alzheimer's disease. Small, soluble Aβ oligomers have been shown more neurotoxic than large, insoluble aggregates and fibrils. Recent studies suggest that biometal ions, including Zn(II), may play an important role process. Experimentally determining details binding process complicated by kinetic lability zinc. To study dynamic nature zinc-bound complexes potential mechanisms which Zn(II) affects...
Emerging evidence indicates that vascular stress is an important contributor to the pathophysiology of Alzheimer's disease and related dementias (ADRD). Hydrogen sulfide (H2S) its metabolites (acid-labile (e.g., iron-sulfur clusters) bound per-, poly-) sulfides) have been shown modulate both neuronal homeostasis. We recently reported elevated plasma sulfides were associated with cognitive dysfunction measures microvascular in ADRD. Here we extend our previous work show associations between...
A previously healthy man in his 30s presented to the emergency department severe respiratory distress with an oxygen saturation of 75% after using a sodium hypochlorite-based household bleach clean bath. He was admitted intensive care unit and required period high-flow nasal but ultimately made full recovery. Sodium hypochlorite can release toxic gases when mixed acids or ammonia, such illness following exposure isolation has not been reported literature. It is important for providers be...
✓ To assess the relationship between posttraumatic cerebral hyperemia and focal damage, authors performed blood flow mapping studies by single-photon emission computerized tomography (SPECT) in 53 patients within 3 weeks of brain injury. Focal zones were present 38% patients. Hyperemia was correlated with clinical features early (CT) magnetic resonance (MR) imaging 48 hours SPECT study late CT MR at months. The observed primarily structurally normal tissue (both gray white matter), as...