Han Lu

ORCID: 0000-0002-6428-8475
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About
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Research Areas
  • Plant Molecular Biology Research
  • Plant Gene Expression Analysis
  • RNA Research and Splicing
  • Plant Stress Responses and Tolerance
  • Plant Reproductive Biology
  • Plant Micronutrient Interactions and Effects
  • RNA and protein synthesis mechanisms
  • Plant biochemistry and biosynthesis
  • Genomics and Chromatin Dynamics
  • Maternal and fetal healthcare
  • Gut microbiota and health
  • Biofuel production and bioconversion
  • Infections and bacterial resistance
  • Plant responses to water stress
  • Calcium signaling and nucleotide metabolism
  • Wheat and Barley Genetics and Pathology
  • Sirtuins and Resveratrol in Medicine
  • Pulmonary Hypertension Research and Treatments
  • Bariatric Surgery and Outcomes
  • Plant tissue culture and regeneration
  • Skin and Cellular Biology Research
  • Ion-surface interactions and analysis
  • Birth, Development, and Health
  • CRISPR and Genetic Engineering
  • Insect symbiosis and bacterial influences

South China Agricultural University
2023-2024

King's College London
2024

Henan Agricultural University
2024

Central South University
2024

Inner Mongolia University
2024

Shaoguan University
2024

Second Xiangya Hospital of Central South University
2024

Quzhou University
2024

University of Electronic Science and Technology of China
2024

Northeast Forestry University
2019-2023

Summary Many Actinidia cultivars are characterized by anthocyanin accumulation, specifically in the inner pericarp, but underlying regulatory mechanism remains elusive. Here we report two interacting transcription factors, Ac MYB 123 and Acb HLH 42, that regulate tissue‐specific biosynthesis pericarp of chinensis cv. Hongyang. Through transcriptome profiling analysis identified five three bHLH factors were upregulated pericarp. We show combinatorial action them, is required for activating...

10.1111/tpj.14330 article EN publisher-specific-oa The Plant Journal 2019-03-26

Zinc (Zn) is an essential micronutrient but in excess highly toxic to plants. Plants regulate Zn homeostasis and withstand through various pathways; these pathways are generally tightly regulated by a specific set of genes. However, the transcription factors involved tolerance have yet be identified. Here, we characterized

10.1104/pp.18.01495 article EN PLANT PHYSIOLOGY 2019-06-20

Adventitious root (AR) formation is critically important in vegetative propagation through cuttings some plants, especially woody species. However, the underlying molecular mechanisms remain elusive. Here, we report identification of a poplar homeobox gene, PuHox52, which was induced rapidly (within 15 min) at basal ends stems upon cutting and played key regulatory role adventitious rooting. We demonstrated that overexpression PuHox52 significantly increased number ARs while suppression had...

10.1111/nph.16778 article EN New Phytologist 2020-06-27

DddA-derived cytosine base editors (DdCBEs) greatly facilitated the basic and therapeutic research of mitochondrial DNA mutation diseases. Here we devise a saturated spacer library successfully identify seven DddA homologs by performing high-throughput sequencing based screen. DddAs Streptomyces sp. BK438 Lachnospiraceae bacterium sunii NSJ-8 display high deaminase activity with strong GC context preference, Ruminococcus AF17-6 is highly compatible to AC context. We also find that different...

10.1038/s41467-023-42359-3 article EN cc-by Nature Communications 2023-10-19

Pulmonary hypertension (PH) due to left heart disease (LHD) is a common condition associated with significant morbidity. It contributes the elevation of pulmonary vascular resistance and mean pressure, eventually leading failure even mortality. The present study aimed explore potential efficacy late long‑term treatment Rho‑kinase (ROCK) signaling inhibitor, namely fasudil, in rat model end‑stage PH‑LHD. PH‑LHD was established by supracoronary aortic banding, effect fasudil on progression...

10.3892/ijmm.2018.3728 article EN cc-by-nc-nd International Journal of Molecular Medicine 2018-06-13

It is of great importance to better understand how trees regulate nitrogen (N) uptake under N deficiency conditions which severely challenge afforestation practices, yet the underlying molecular mechanisms have not been well elucidated. Here, we functionally characterized PuHox52, a Populus ussuriensis HD-ZIP transcription factor, whose overexpression greatly enhanced nutrient and plant growth deficiency. We first conducted an RNA sequencing experiment obtain root transcriptome using...

10.1111/jipb.13389 article EN Journal of Integrative Plant Biology 2022-10-13

SQUAMOSA promoter binding protein-like (SPL) is a unique family of transcription factors in plants, which engaged regulating plant growth and development, physiological biochemical processes. Fraxinus mandshurica an excellent timber species with wide range uses northeastern China enjoys high reputation the international market. SPL analysis has been reported some plants while not reported.We used phylogeny, conserved motifs, gene structure, secondary structure prediction, miR156 sites, cis...

10.1186/s12870-022-03838-9 article EN cc-by BMC Plant Biology 2022-09-21

Xylem development plays a crucial role in wood formation woody plants. In recent years, there has been growing attention towards the impact of brassinosteroids (BRs) on this xylem development. present study, we evaluated dynamic variation Fraxinus mandshurica (female parent, M8) and novel interspecific hybrid F. × sogdiana (1601) from May to August 2020. We obtained RNA-Seq transcriptomes three tissue types (xylem, phloem, leaf) identify differences xylem-differentially expressed genes...

10.3389/fpls.2023.1167548 article EN cc-by Frontiers in Plant Science 2023-07-17

Lysine succinylation (Ksu) has recently emerged as a protein modification that regulates diverse functions in various biological processes. However, the systemically and precise role of lysine erythropoiesis remains to be fully elucidated. In this study, we noted prominent increase succinyl-CoA during human erythroid differentiation. To explore functional significance succinylation, inhibited by either knock downing key succinyltransferases or overexpressing desuccinylases. Succinylation...

10.3324/haematol.2024.285752 article EN cc-by-nc Haematologica 2024-10-17

Populus ussuriensis Kom. is one of the most important tree species for forest renewal in eastern mountainous areas Northeast China due to its fast growth, high yield, and significant commercial ecological value. The selection optimal reference genes normalization qRT-PCR data essential analysis relative gene expression. In this study, fourteen were selected assessed their expression stability during abiotic stress (drought, salinity, cold stress) after treatment with drought-related hormone...

10.3390/f11040476 article EN Forests 2020-04-23

Plant leaves, as one of the main organs plants, have a crucial impact on plant development. In hybrid F1 variety, clone “1601” from hybridization Fraxinus mandshurica Rupr. × sogdiana Bunge was showed significant differences in leaf development with its female control “M8”. The phenotypic leaflets and fronds, photosynthesis parameters, rate water loss cell size were investigated between 1601 M8. details that significantly smaller (leaflet 53.78% M8) rounder aspect ratio 66.97% M8). Its...

10.3390/f14081554 article EN Forests 2023-07-29

Chilo supprressalis is one of the most important rice pests that causes serious damage to production in growth area Asia. Vetiver grass (Vetiveria zizanioides) was previously found effectively attract female adults C. suppressalis laying eggs on vetiver leaves, while larvae cannot complete their life cycles by feeding vetiver, indicating a potential means controlling this pest. In present study, transcriptomes midguts rice-fed and vetiver-fed were profiled, which aimed clarify molecular...

10.3389/fphys.2018.01067 article EN cc-by Frontiers in Physiology 2018-08-07

Maize tassel spindle length is closely related to the number of pollen grains and duration flowering stage, ultimately affecting maize yield adaptations stress conditions. In this study, 182 inbred lines were included in an association population. A genome-wide study was conducted on using Q + K model. With

10.3390/genes15111413 article EN Genes 2024-10-31

The interaction of transcription factors (TFs) with DNA precisely regulates gene transcription. In mammalian cells, thousands TFs often interact cis-regulatory elements in a combinatorial manner rather than act alone. identification cooperativity between can help to explore the mechanism transcriptional regulation. However, little is known about cooperative patterns genome. To identify which prefer co-localisation, authors conducted paired motif analysis accessible regions human genome based...

10.1049/syb2.12104 article EN cc-by-nc IET Systems Biology 2024-11-26
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