A5053413385- Cardiac electrophysiology and arrhythmias
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Chemotherapy-induced cardiotoxicity and mitigation
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Heart Rate Variability and Autonomic Control
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Pharmaceutical Practices and Patient Outcomes
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Circadian rhythm and melatonin
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Disease and Adiposity
- Cardiovascular and exercise physiology
- Mast cells and histamine
Comenius University Bratislava
2016-2025
Detská Fakultná Nemocnica s Poliklinikou
2024
Masaryk University
2022
University College Dublin
2021
British Columbia Centre on Substance Use
2021
University of British Columbia
2021
AIDS Vancouver
2021
University of Birmingham
2014
Hebrew University of Jerusalem
2014
Technion – Israel Institute of Technology
2014
Abstract Since the identification of alternative angiotensin converting enzyme ( ACE )2/Ang‐(1‐7)/Mas receptor axis, renin‐angiotensin system RAS ) is a new complex target for pharmacological intervention. We investigated expression components in heart and kidney during development hypertension its perinatal treatment with losartan young spontaneously hypertensive rats SHR ). Expressions genes were studied by RT ‐ PCR left ventricle rats: normotensive Wistar, untreated SHR, treated since...
Abstract In this study, a role of cell loss due to necroptosis and its linkage with pyroptosis in organ damage under the conditions pulmonary arterial hypertension (PAH) was examined. Monocrotaline (MCT) used induce PAH Wistar rats, depending on severity disease progression, they were further divided into two subgroups: MCT group—sacrificed 4 weeks after administration ptMCT group—prematurely sacrificed rapid deterioration vital functions (on Day 24,11 ± 0,7). The elevation respiratory rate...
Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether receptors increase contractility human heart. Therefore, we have generated mice that overexpress D
There is controversy whether H<sub>1</sub>-histamine receptors increase or decrease contractility in the mammalian heart. Therefore, we have generated mice that overexpress human receptor heart (H<sub>1</sub>-TG). We hypothesized histamine would either force of contraction and beating rate compared to littermate wild type (WT). In H<sub>1</sub>-TG mice, ascertained presence by autoradiography atrium ventricle using [<sup>3</sup>H]mepyramine. The messenger RNA for...
QT interval is prolonged in hypertensive individuals, although the factors responsible for this increase are not completely understood. We questioned whether enhanced left ventricular mass (LVM) or increased systemic blood pressure represents principal factor determining prolongation period of development hypertension and hypertrophy (LVH) spontaneously rats (SHR). In 12-and 20-week-old SHR (SHR12 SHR20) age-matched normotensive Wistar-Kyoto (WKY12 WKY20), arterial systolic (sBP) was...
Abstract The aim of this study was to describe the effects Pycnogenol ® at various doses on preprandial and postprandial glucose levels, levels thiobarbituric acid reactive substances (TBARs) N ‐acetyl‐ β ‐ d ‐glucosaminidase (NAGA) motor nerve conduction velocity (MNCV) in streptozotocin (STZ)‐induced diabetic rats. treatment (10, 20, 50 mg/kg body weight (b.w.)/day) lasted for 8 weeks after induction diabetes. significantly decreased elevated glycaemia treated animals all doses. At 10...
We studied whether Pycnogenol (PYC) may attenuate the development of experimental streptozotocin-induced diabetic cardiomyopathy in rat. In addition, we aimed to study PYC affects cardiac oxidative stress and protein expression reactive oxygen species (ROS)-producing molecules (gp91(phox)-containing NADPH oxidase NO-signalling proteins). Experimental diabetes mellitus was manifested by hyperglycaemia impaired function estimated using left ventricular catheterisation vivo. lowered fasting...
The role of hepatocyte growth factor (HGF) in diabetic kidney damage remains controversial.To test the hypothesis that high glucose levels activate pathways related to HGF and its receptor Met this could participate glucose-induced renal cell damage.HK2 cells, a human proximal tubule epithelial line, were stimulated with for 48 hours. Levels pMet/Met, pEGFR/EGFR, pSTAT3/STAT3, pAkt/Akt pERK1/2/ERK1/2 studied by immunoblotting. Absence was verified qRT-PCR ELISA.High level activated...
Pulmonary hypertension (PH) is characterised by an increase in pulmonary arterial pressure, ultimately leading to right ventricular failure and death. We have previously shown that nerve growth factor (NGF) plays a critical role PH. Our objectives here were determine whether NGF controls Connexin-43 (Cx43) expression function the smooth muscle, this mechanism contributes NGF-induced artery hyperreactivity.
Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist. GLP-1R agonists are used to treat type 2 diabetes and obesity. It currently unknown whether semaglutide can directly increase force of contraction (FOC) in the human heart. We tested hypothesis that might FOC isolated atrium. To this end, we conducted experiments right atrial muscle preparations (HAP). HAP were obtained during open-heart surgery. detected concentration- time-dependent positive inotropic effect (PIE) HAP....