A5024119039- HIV Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Functional Brain Connectivity Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Clinical Research Studies
- Epilepsy research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Eosinophilic Esophagitis
- Hepatitis B Virus Studies
- HIV/AIDS Research and Interventions
- Pharmacological Effects and Toxicity Studies
- Liver Diseases and Immunity
- Mast cells and histamine
- Long-Term Effects of COVID-19
- Pneumocystis jirovecii pneumonia detection and treatment
- Reproductive tract infections research
- Bone and Joint Diseases
- Gastrointestinal disorders and treatments
- Neuroscience and Neuropharmacology Research
- Food Allergy and Anaphylaxis Research
- Amoebic Infections and Treatments
Sapienza University of Rome
2012-2023
Azienda Ospedaliera Sant'Andrea
2016-2020
CTO Andrea Alesini
2017-2019
University of Sassari
1996
Policlinico Umberto I
1987-1991
Hospital for Tropical Diseases
1991
To assess the participation of four subclasses IgG in humoral response to Echinococcus granulosus infection, we determined total and parasite-specific IgG1, IgG2, IgG3 IgG4 sera from 46 patients with hydatid disease using an enzyme-linked immunosorbent assay (ELISA). Parasite-specific subclass antibodies were quantitatively measured by means standard curves obtained affinity chromatography. Sera 35 healthy individuals served as controls. The component showed a slight increase hydatidosis...
HIV-1 non-B subtypes/circulating recombinant forms (CRFs) are increasing worldwide. Since subtype identification can be clinically relevant, we assessed the added value in subtyping using updated molecular phylogeny (Mphy) and performance of routinely used automated tools. Updated Mphy (2015 reference sequences), as a gold standard, was performed to 13,116 protease/reverse transcriptase sequences then compared with previous (reference until 2014) COMET, REGA, SCUEAL, Stanford classified B...
Background Increased evidence of relevant HIV-1 epidemic transmission in European countries is being reported, with an increased circulation non-B-subtypes. Here, we present two recent non-B clusters characterized by NNRTI-related amino-acidic mutations among newly diagnosed infected men, living Rome (Central-Italy). Methods Pol and V3 sequences were available at the time diagnosis for all individuals. Maximum-Likelihood Bayesian phylogenetic-trees bootstrap Bayesian-probability supports...
Objective We evaluated the characteristics of HIV-1 molecular transmission clusters (MTCs) in 1890 newly diagnosed individuals infected with non-B subtypes between 2005 and 2017 Italy. Methods Phylogenetic analyses were performed on pol sequences to characterise subtypes/circulating recombinant forms identify MTCs. MTCs divided into small (SMTCs, 2–3 sequences), medium (MMTCs, 4–9 sequences) large (LMTCs, ≥10 sequences). Factors associated using logistic regression analysis. Results 145...
Transmitted drug-resistance (TDR) remains a critical aspect for the management of HIV-1-infected individuals. Thus, studying dynamics TDR is crucial to optimize HIV care. In total, 4323 HIV-1 protease/reverse-transcriptase sequences from drug-naive individuals diagnosed in north and central Italy between 2000 2014 were analysed. was evaluated over time. Maximum-likelihood Bayesian phylogenetic trees with bootstrap Bayesian-probability supports defined transmission clusters. Most males...
Patients co-infected with hepatitis C virus (HCV) and human immunodeficiency (HIV) are at high risk of liver disease progression. We report a favorable safety profile SVR12 rates 96.7% among HIV/HCV patients participating in an Italian compassionate-use program ombitasvir/paritaprevir/ritonavir + dasabuvir (OBV/PTV/r DSV) ± ribavirin (RBV).
Human herpes virus 8 (HHV8) is the causative agent of Kaposi's sarcoma and has been associated with an increasing number hematologic diseases such as primary effusion lymphoma (PEL) (both classic extracavitary form), multicentric Castleman disease germinotropic lymphoproliferative disorder. PEL a rare B cell non-Hodgkin that primarily affects immunocompromised patients; aggressive chemotherapy antiretroviral therapy (ART) protease inhibitors have used, poor results. We present case in...
Here we tested the effect of combined antiretroviral therapy (cART) on deviant electroencephalographic (EEG) source activity in treatment-naïve HIV individuals. Resting state eyes-closed EEG data were recorded before and after 5 months cART 48 male subjects, who naïve at study start. The also 59 age- sex-matched healthy subjects as a control group. Frequency bands interest included delta, theta, alpha1, alpha2 alpha3, based alpha frequency peak specific to each individual. They beta1 (13–20...
Summary An evaluation of the use histamine release test (HRT) in diagnosis human hydatidosis is presented. This technique, which makes it possible to evaluate directly IgE dependent immediate hypersensitivity by measuring released from leucocytes (basophils) after antigenic challenge, was compared with detection serum specific radio‐allergosorbent (RAST), and determination enzyme‐linked immunosorbent assay (ELISA). Of 54 patients hydatidosis, all were positive according HRT, 42 RAST 47...
Hepatitis B virus (HBV) circulation was surveyed in three Somalian villages (Buur-Fuul, Mooda-Moode and Bajuni Islands) different districts 52 children living a closed community, aged under one year, were studied. Of the 331 village subjects to 83 years, 12·08% HBs positive, 29·9% anti-HBs 43·8% anti-HBc positive 21·4 anti-HBe positive. Among HBs-positive subjects, 34·7% had HBeAg 21·7% anti-HBcAg-IgM. No statistically significant differences found for HBs, anti-HBs, among villages....