A5056886461- HIV-related health complications and treatments
- Nutrition and Health in Aging
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Research and Interventions
- Frailty in Older Adults
- Energy and Environment Impacts
- Air Quality and Health Impacts
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Hip and Femur Fractures
- Patient Satisfaction in Healthcare
- HIV/AIDS drug development and treatment
- Grief, Bereavement, and Mental Health
- Cerebral Palsy and Movement Disorders
- Viral-associated cancers and disorders
- Atmospheric chemistry and aerosols
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Food Security and Health in Diverse Populations
- Cytomegalovirus and herpesvirus research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Cervical Cancer and HPV Research
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
Colorado School of Public Health
2018-2024
University of Colorado Anschutz Medical Campus
2018-2023
University of Michigan
2020
Harvard University
2018
Cancer Research And Biostatistics
2017
Colorado is regularly impacted by long-range transport of wildfire smoke from upwind regions. This a major source ambient PM2.5. Maternal exposure to total PM2.5 during pregnancy has been linked decreased birth weight and other adverse outcomes, although the impact contribution only recently investigated. The objective this study was estimate associations between outcomes Wildfire exposures were estimated using previously published method incorporating ground-based monitors remote sensing...
Both frailty and falls occur at earlier-than-expected ages among HIV-infected individuals, but the contribution of frailty-to-fall risk in this population is not well understood. We examined association participants enrolled AIDS Clinical Trials Group (ACTG) A5322.A prospective, multicenter cohort study men women aged least 40 years.Frailty assessment included a 4-m walk, grip strength, self-reported weight loss, exhaustion, low physical activity. Multinomial logistic regression assessed...
Neurocognitive impairment (NCI) is strongly associated with frailty in people living human immunodeficiency virus (PLWH); the overlap of and NCI impact on health outcomes PLWH are unknown.PLWH a longitudinal, observational study aging completed entry evaluations for NCI. Outcomes falls (recurrent) increased limitations independent activities daily (IADL), or mortality were combined. Poisson regression models estimated prevalence ratios (PR) ≥1 outcome over 2 years.Among 987 participants,...
Frailty and physical function impairments occur at an earlier than expected age in people with HIV (PWH). The goal of this study was to determine which tools or combination assessing frailty/physical were most predictive mortality a middle-aged population PWH.Using electronic health records, we determined survival, death, loss follow-up for 359 PWH, aged 45-65 years originally enrolled 2009-2010 cross-sectional cohort study. accuracy various measures [frailty score, Veterans Aging Cohort...
Kamis, Kevin F. MPH; Barbera, Lauren MD(c); Abdo, Mona PhD(c); Rowan, Sarah E. MD; Hussain, Cory Gardner, Edward M. Johnson, Steven C. MaWhinney, Samantha ScD; Davis, Amelia J. Carlson, Jesse MPH(c); Kozacka, Katie A. Erlandson, Kristine MD, MS Author Information
Impairments in physical function and increased systemic levels of inflammation have been observed middle-aged older persons with HIV (PWH). We previously demonstrated that persons, associations between gut microbiota differed by serostatus. To determine whether relationships the microbiome measurements would also be distinct without HIV, we reanalyzed existing short chain fatty acid (SCFA) data conjunction collected body composition from same cohorts (51-74 years), nonfrail PWH receiving...
Abstract Background Household air pollution (HAP) from cooking with solid fuels has adverse health effects. REACCTING (Research on Emissions, Air quality, Climate, and Cooking Technologies in Northern Ghana) was a randomized cookstove intervention study that aimed to determine the effects of two types “improved” biomass cookstoves using self-reported symptoms biomarkers systemic inflammation dried blood spots for female adult cooks children, anthropometric growth measures children only....
Abstract Background In this study, we evaluate associations between cumulative antiretroviral adherence/exposure, quantified using tenofovir diphosphate (TFV-DP) in dried blood spots (DBS), and human immunodeficiency virus (HIV)-related aging factors. Methods This is a cross-sectional analysis of younger (ages 18–35) older ≥60) persons with HIV (PWH) taking TFV disoproxil fumarate. Tenofovir concentrations were DBS. Linear logistic regression models used to TFV-DP bone mineral density (BMD),...
Background: The longer-term risks of statins on physical function among people with HIV are unclear. Methods: Longitudinal analysis Multicenter AIDS Cohort Study men between 40 and 75 years age ≥2 measures gait speed or grip strength. Generalized estimating equations interaction terms (1) statin use (2) serostatus, age, were considered to evaluate associations function. Models adjusted for demographics cardiovascular risk factors. Results: Among 2021 (1048 HIV), baseline median was 52...
Background People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals without HIV. We examined whether baseline was associated subsequent impairments. Methods Associations of frailty (gait speed [m/sec], grip strength [kg]) (< 80% predicted diffusing capacity for carbon monoxide [DL
Mortality for people living with HIV (PLWH) has dramatically decreased since the mid-1990s and proportion of deaths attributable to non-AIDS-related conditions increased. Deceased PLWH were identified from a single academic medical center through provider survey electronic record query. Cause death was determined using Coding Causes Death in tool following review available records. Chart comorbidities, demographics, laboratory values, previous completion screening tests malignancies...
Mortality for people living with HIV (PLWH) has drastically decreased since the mid-1990s, and proportion of deaths due to non-HIV-related conditions increased. Deceased PLWH were identified within a single academic medical center. Cause death was determined by chart review, clinic providers, when available autopsy toxicology data. Chart review comorbidities, demographics preventable causes cancer conducted during period 2013–2017. The AIDS-related markedly between 1995 2017, while from...
More than 80% of antibiotics are prescribed in the outpatient setting, which 30% inappropriate. The National Action Plan for Combating Antimicrobial Resistance called a 50% decrease antibiotic use by 2020. Inappropriate associated with adverse reactions and Clostridioides difficile infection, especially among older adults.Before after study.We performed quality improvement initiative at University Colorado Seniors Clinic. Providers received education on guidelines, electronic order sets were...
Geographic location was a strong predictor of falls among women with and without HIV in the Women's Interagency Study. We examined regional variation more geographically diverse cohort older people (PWH) explored whether physical activity, sex, or body–mass index modified these associations. PWH enrolled A5322 HAILO (HIV Infection, Aging, Immune Function Long-Term Observational Study). Participants who reported 6 months before each semiannual visit had ≥1 consecutive pair fall assessments...
People living with HIV have greater pulmonary function impairments and decreased health-related quality of life (HRQoL) compared to uninfected peers. We examined whether impairment was associated HRQoL or respiratory health status. Using Multicenter AIDS Cohort Study data (2017–2019), associations between outcomes [HRQoL (36-Item Short Form Survey) status (St. George's Respiratory Questionnaire)] [diffusing capacity for carbon monoxide (DLCO) forced expiratory volume in 1 s (FEV1), defined...
Abdo, Mona MPH; Ressler, Adam MD; MaWhinney, Samantha ScD; Jankowski, Catherine PhD; Johnson, Steven C. Erlandson, Kristine M. MD, MS Author Information
Abstract We sought to determine effects of age, HIV serostatus, and smoking on the associations between pulmonary function physical impairments using Multicenter AIDS Cohort Study data. Associations outcomes gait speed (m/sec) grip strength (kg) with normalized tests (diffusion capacity for carbon monoxide (DLCO, n=1,048) forced expiratory volume in one second (FEV1, n=1,029)) were examined. Adjusted mixed-effects models included interaction terms assess effect modification. 574(55%) HIV+,...