A5038567707- Obesity, Physical Activity, Diet
- SARS-CoV-2 and COVID-19 Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- COVID-19 epidemiological studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Risk Factors
- Primary Care and Health Outcomes
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Health and Lifestyle Studies
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Eating Disorders and Behaviors
- Obesity and Health Practices
- Blood Pressure and Hypertension Studies
- Ovarian function and disorders
- Innovations in Medical Education
- Health Promotion and Cardiovascular Prevention
- Chronic Disease Management Strategies
- Reproductive Health and Contraception
- Sperm and Testicular Function
- COVID-19 and healthcare impacts
- Physical Activity and Health
- Animal Virus Infections Studies
Aga Khan University
2018-2025
Aga Khan University Hospital
2023-2025
Day Family Medicine
2023
Bridge University
2022
University Research Co (United States)
2022
Children's Hospital at Montefiore
2005-2021
Brown University
2015-2018
Albert Einstein College of Medicine
2005-2015
Centre Hospitalier Universitaire de Liège
2014
Yeshiva University
2010-2012
Hypertension is a major cause of cardiovascular disease and deaths worldwide especially in low- middle-income countries. Despite the availability safe, well-tolerated, cost-effective blood pressure (BP)-lowering therapies, <14% adults with hypertension have BP controlled to systolic/diastolic <140/90 mm Hg. We report new treatment guidelines, developed accordance World Health Organization Handbook for Guideline Development. Overviews reviews evidence were conducted summary tables...
Rationale: Mechanisms leading to obstructive sleep apnea syndrome (OSAS) in obese children are not well understood.Objectives: The aim of the study was determine anatomical risk factors associated with OSAS as compared control subjects without OSAS.Methods: Magnetic resonance imaging used size upper airway structure, and body fat composition. Paired analysis compare between groups. Mixed effects regression models conditional multiple logistic were whether mass index (BMI) Z-score an effect...
Nearly one‐third of obese individuals are classified as metabolically benign; however whether this subgroup is at a lower risk cardiovascular disease (CVD) unclear. Using pooled data from the Atherosclerosis Risk in Communities and Cardiovascular Health Studies, we assessed incident CVD (coronary heart stroke) using three definitions benign phenotype: (i) ATP‐III metabolic syndrome definition (≤2 components, excluding abdominal obesity (ii) expanded (≤1 of: any insulin resistance (IR), or...
Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors which increase the likelihood developing type 2 diabetes and cardiovascular disease. This study aimed to determine prevalence MetS among adolescents living in slums aged 11–18 years Karachi, Pakistan. Data were collected from 689 attending five schools two slum areas Korangi Baldia, February 2023 March 2023. Measurements weight, height, waist circumference, blood pressure obtained participants. Blood samples assess...
Purpose The purpose of this study was (1) to examine the reasons for managing weight, (2) investigate barriers and facilitators achieving behavior goals, (3) assess how a coach affects goalsetting process obese innercity adolescents in weight management program. Methods Obese participating pilot assessing role on successful (n = 18) were interviewed identify reaching goals. Data analyzed using descriptive statistics constant comparative method qualitative analysis. Results In rationale...
Environmental factors are pivotal in shaping disease outcomes for obesity, diabetes, and metabolic syndrome (MetS), especially the Pakistani population. This study aimed to determine whether promoter methylation levels of 12 diabetes obesity susceptibility genes associated with MetS phenotypes risk T2DM individuals. A cross-sectional was undertaken whereby methylation-specific PCR assays were conducted on 203 adult subjects recruited from community Karachi, Pakistan. Participants stratified...
To assess the perceptions of medical students about Family Medicine (FM) as a career choice and to examine if exposure FM in undergraduate curriculum is associated with positive perception FM. Cross-sectional study. The study was conducted four universities Karachi out which two were public private sectors. From July 2021 January 20 22. investigator administered structured questionnaire person participants. Quantitative data collected, descriptive statistics computed. Association between...
With the rising epidemic of cardiometabolic diseases (CMDs) in low- and middle-income countries, urban populations face unique challenges such as poor sanitation, environmental pollution, limited access to healthcare. This study estimates point prevalence CMDs associated risk factors adults Karachi, analyses CMD by sex, explores relationship between depression. A door-to-door survey was conducted a densely populated community within 0.5 km radius primary health centre. minimum 1,480 families...
Metabolic syndrome (MetS) significantly increases the risk of cardiovascular disease (CVD). Healthcare workers (HCWs) are at a higher CVD. However, little is known about association between MetS and CVD in healthcare Pakistan. We aimed to assess prevalence its components examined 10-year CVD-risk using Framingham Risk Score (FRS) common factors amongst HCWs working private system This cross-sectional study uses baseline data from an existing screening program for employees was diagnosed...
Abstract Background The primary healthcare system in Pakistan focuses on providing episodic, disease-based care. Health care for low-middle income communities is largely through a fee-for-service model that ignores preventive and health-promotive services. growing burden of cardiovascular illnesses requires restructuring the health allowing community-to-clinic to improve patient- community-level indicators. Methods We propose integrates Patient-Centered Medical Home (PCMH) with...
COVID-19 epidemiology changed with the emergence of SARS-CoV-2 variants concern (VOC). Pakistan administered mostly inactivated vaccines. We investigated association between VOC and breakthrough infections in a mixed-vaccination-status population Karachi.
In humans and mice, sensitization to respiratory syncytial virus (RSV) Ags can result in severe inflammatory lung disease during subsequent infection with RSV. Although specific antiviral T cells are thought be responsible for this augmentation of disease, the precise roles different functional subsets unknown, no protective nonpathogenic subset has been defined. BALB/c mice sensitized major surface glycoprotein RSV (G) expressed by recombinant vaccinia develop Th2-driven eosinophilia after...
Objective Nearly, a third of obese individuals, termed metabolically benign obese, have low burden adiposity‐related cardiometabolic abnormalities, whereas substantial proportion normal‐weight individuals possess risk factors. Methods In cross‐sectional analyses 699 normal weight and 1,294 overweight/obese postmenopausal women enrolled in nested case‐control stroke study ancillary to the Women's Health Initiative Observational Study, we compared levels adiponectin, leptin, resistin among...
Background: The burden of depression among Hispanics/Latinos indicates the need to identify factors related depressive symptoms. This paper examines relationship physical activity (PA) and sedentary behavior (SB) with symptoms in Hispanic/Latinos. Methods: Hispanic Community Health Study / Latinos (HCHS/SOL) is a population-based, cohort study Hispanic/Latinos 4 United States metropolitan areas. Objectively measured PA was coded into: (SB), light-intensity (LPA), moderate-intensity (MPA),...
COVID-19 vaccinations have reduced morbidity and mortality from the disease. Antibodies against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) been associated with immune protection. Seroprevalence studies revealed high immunoglobulin G (IgG) antibody levels to SARS-CoV-2 in Pakistani population before vaccinations. We investigated effect of BBIBP-CorV vaccination on circulating IgG antibodies interferon (IFN)-γ T cells measured a cohort healthy individuals, respect age,...
The published literature regarding the relationships between retinol-binding protein 4 (RBP4) and cardiometabolic risk factors subclinical atherosclerosis is conflicting, likely due, in part, to limitations of frequently used RBP4 assays. Prior large studies have not utilized gold-standard western blot analysis levels.Full-length serum levels were measured by 709 postmenopausal women screened for Kronos Early Estrogen Prevention Study. Cross-sectional analyses related factors, carotid artery...
Little is known about the natural history of progression from a metabolically benign overweight/obese (MBO) to at-risk (ARO) phenotype. Improved understanding would help clinicians focus on controlling risk factors that predispose an obese individual progression. Using discrete-time proportional hazard modeling data Study Women's Health Across Nation (SWAN), we examined incident MBO (less than two metabolic syndrome abnormalities) ARO (two or more and associated with over 7-year period. Of...