A5087764866- Crystallization and Solubility Studies
- Exercise and Physiological Responses
- Sports Performance and Training
- X-ray Diffraction in Crystallography
- Biochemical effects in animals
- Children's Physical and Motor Development
- Cholinesterase and Neurodegenerative Diseases
- Trace Elements in Health
- Selenium in Biological Systems
- High Altitude and Hypoxia
- Environmental Toxicology and Ecotoxicology
- Free Radicals and Antioxidants
- Medicinal Plants and Neuroprotection
- Biochemical Acid Research Studies
- Cardiovascular and exercise physiology
- Sperm and Testicular Function
- Seaweed-derived Bioactive Compounds
- Neuropeptides and Animal Physiology
- Reproductive Biology and Fertility
- Body Composition Measurement Techniques
- Crystallography and molecular interactions
- Sulfur Compounds in Biology
- Insect and Pesticide Research
- Stress Responses and Cortisol
- Heme Oxygenase-1 and Carbon Monoxide
Bulgarian Academy of Sciences
2014-2024
Institute of Neurobiology
2014-2024
National Sports Academy Vassil Levski
2017-2024
Vladivostok State Medical University
2023
Ministry of Health of the Russian Federation
2023
Chuvash State Agricultural Academy
2020
Institute of Plant Biology and Biotechnology
2019
Medical University Plovdiv
2009
Background: Oxidative stress affects sperm quality negatively.To maintain the pro/antioxidant balance, some metal ions (e.g.copper, zink, iron, selenium), which are co-factors of antioxidant enzymes, essential.However, iron and copper could act as prooxidants inducing oxidative damage spermatozoa.Aims: To reveal a possible correlation between concentrations (iron, copper, zinc, selenium) in human seminal plasma, stress, assessed by malondialdehyde total glutathione levels, semen quality,...
We compared the neuroprotective action of three natural bio-antioxidants (AOs): ellagic acid (EA), α-lipoic (LA), and myrtenal (Myrt) in an experimental model Parkinson’s disease (PD) that was induced male Wistar rats through intrastriatal injection 6-hydroxydopamine (6-OHDA). The animals were divided into five groups: sham-operated (SO) control group; striatal 6-OHDA-lesioned groups pre-treated for days with EA, LA, Myrt (50 mg/kg; intraperitoneally- i.p.), respectively. On 2nd 3rd week...
Voluntary certification of non-food consumer goods production compliance with the conditions and standards that exclude presence carcinogens in finished products allows manufacturing enterprises to reach new, safer level production, both for workers, simplifying control procedure, consumers fi nished products. Confi rmed quality allows, due a unique selling proposition, signifi cantly expand audience, as well increase sales volumes The described advantages certifi cation do not contain...
There is growing attention on natural substances capable of stimulating the cholinergic system and exerting antioxidant effects, as potential therapeutic agents in Alzheimer's disease (AD). The aim present study to evaluate expected neuroprotective mechanisms myrtenal (M) an experimental model dementia rats. Dementia was induced male Wistar rats by scopolamine (Sc) administration (0.1 mg/kg for 8 days 20.0 day 9). animals were divided into 5 groups (1) Controls; (2) Sc; (3) Sc + Myrtenal (40...
Alzheimer's disease (AD) is a complex neurodegenerative with multifactorial etiology, unsatisfactory treatment, and necessity for broad-spectrum active substances cure. The mucus from Helix aspersa snail mixture of bioactive molecules antimicrobial, anti-inflammatory, antioxidant, anti-apoptotic effects. So far there are no data concerning the capacity extract (SE) to affect disorders.The effects SE on learning memory deficits in type dementia (ATD) induced by scopolamine (Sco) male Wistar...
The difficult-to-heal wounds continue to be a problem for modern medicine. Chitosan and diosgenin possess anti-inflammatory antioxidant effects making them relevant substances wound treatment. That is why this work aimed study the effect of combined application chitosan on mouse skin model. For purpose, (6 mm diameter) were made mice’s backs treated 9 days with one following: 50% ethanol (control), polyethylene glycol (PEG) in ethanol, PEG (Chs), (Dg) chitosan, (ChsDg). Before first...
Abstract The present study aimed to investigate the effects of pentoxifylline (PTX) on carrageenan (CG)‐induced paw oedema and endogenous levels cell enzyme non‐enzyme antioxidants in rat liver, 4 24 h after CG injection. PTX (50 mg kg −1 , i.p.), administered 30 min before CG, decreased oedema, 2–4 administration. drug protected CG‐induced decrease glutathione (non‐enzyme antioxidant) had no effect CG‐unchanged activities superoxide dismutase, peroxidase (enzyme antioxidants)...
Alzheimer’s disease (AD), a progressive neurodegenerative disorder characterized by memory loss and cognitive functions decline, is leading cause for dementia currently ranked as the sixth foremost of death. As present, treatment AD symptomatic without convincing therapeutic benefits new, effective, agents are pursued. Due to massive cholinergic neurons decreased acetylcholine levels, cholinesterase inhibitors like galantamine, remain backbone pharmacological disease. In present study, using...
Alzheimer's disease (AD) is a neurodegenerative associated with memory impairment and other central nervous system (CNS) symptoms. Two myrtenal-adamantane conjugates (MACs) showed excellent CNS potential against models. Adamantane common pharmacophore for drug design, myrtenal (M) demonstrated neuroprotective effects in our previous studies. The aim of this study to evaluate the MACs' properties dementia.Scopolamine (Scop) was applied intraperitoneally Wistar rats 11 days, simultaneously...
Abstract In vivo effects of N ‐benzyloxycarbonyl (Cbz)‐Leu–Leu‐leucinal (MG132) on chymotryptic‐like (ChT‐L), tryptic‐like, and post‐glutamyl peptide hydrolytic‐like proteasome activities, protein oxidation, lipid peroxidation (LP), glutathione (GSH) level, as well the activity antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), peroxidase (GSH‐Px), glutathione‐reductase) in rat liver were studied. The possibility MG132 provoking formation free oxygen radicals was also assayed...
The pathogenesis of many diseases and different pathological conditions, including inflammation, is associated with excess production reactive oxygen species (ROS). present study aimed to investigate the effects antidepressant desipramine (DES) on carrageenan (CG)-induced as well endogenous levels cell enzyme non-enzyme antioxidants in rat liver spleen, 4 24 h after CG injection. intra-plantar injection into right hind paw resulted a time-dependent increase volume; maximum CG-induced edema...
Artistic gymnastics can be practised from an early age and develops the main components of physical fitness. The aim this study was to assess fitness young competitive artistic gymnasts Bulgaria. A total 161 (81 females 80 males), who were divided into three groups (from 5-8, 9-11, 12-15 years age), with sports experience 12 180 months, took part in study. All participants completed extended version Alpha-Fit test battery, European norms being applied calculate percentile scores for each...
Previous studies have shown that proteasome inhibitors exerted protective effects against ischemia/reperfusion injury (IRI) of brain, heart, kidney and intestine. The aim the present study was to investigate: (i) whether inhibitor MG132 protects rat liver IRI; (ii) modulates prooxidant/antioxidant status subjected warm IRI.The left lateral medial lobes (approximately 70% total volume) livers male Wistar rats were 30-min ischemia followed by 60-min reperfusion. Lactate dehydrogenase (LDH),...
Physical fitness has been shown to be a major health factor in both children and adolescents. One of the most widely applied physical test batteries Europe is Alpha-fit. However, there reference gap between some ages. The aim this study was propose interpolated percentile scores adolescents for main tests Alpha-fit battery, which can temporarily until filled by experimental research. recently available existing European normative values were linearly order close from 9.9 12.9 years age...
This study assessed phytochemical profile and antioxidant capacity of hydrosols, obtained by water-steam distillation Rosa alba L. damascena Mill. plants, grown in experimental field the Institute Rose Essential Oil Plants, Bulgaria. The identification hydrosols' compounds was performed using 7890A/5975 GC-MS system, total phenolic content (TPC) determined quantitatively Folin Ciocalteu reagent, with Gallic acid as standard both hydrosols concentration 0.3 % up to 15 were tested liposomal...
Alzheimer's disease (AD) has long proven to be a complex neurodegenerative disorder, with cholinergic dysfunction, oxidative stress, and neuroinflammation being just few of its pathological features. The complexity the requires multitargeted treatment covering many aspects. In present investigation, an arylhydrazone derivative 5-methoxyindole-2-carboxylic acid (5MeO), in vitro strong antioxidant, neuroprotective monoamine oxidase B-inhibiting effects, was studied scopolamine-induced...
Background and Study Aim: One of the most widely applied methods to assess upper-body strength in children adolescents is handgrip test. While it has been determined which elbow position, type dynamometer are appropriate for achieving maximal grip strength, still not clear. Therefore, purpose this study was investigate whether position affect children. Material Methods: Grip measured by TKK DynX dynamometers, their validity reliability were also analysed. A total 60 children, 6 11 years old,...
Inhibitors of acetylcholinesterase (AChE) are used to treat many disorders, among which neurodegenerative upsets, like Alzheimer's disease (AD). One the limited licensed AChE inhibitors (AChEIs) as drugs is natural compound galantamine (Gal).As Gal a toxic compound, here we expose data about its four derivatives in hybrid peptide-norgalantamine molecules, have shown 100 times lower toxicity.Four newly synthesized been involved docking analysis made by Molegro Virtual Docker. Biological...
Ionizing radiation (IR) and reactive oxygen species (ROS)-induced oxidative stress can cause damage to cellular biomolecules, including DNA, proteins, lipids. These harmful effects compromise essential functions significantly raise the risk of metabolic dysfunction, accumulation mutations, genome instability, cancer, accelerated senescence, even death. Here, we present an investigation HeLa cancer cells' early response gamma IR (γ-IR) after preincubation cells with natural extracts resurrection plant
Alzheimer’s disease manifests as a complex pathological condition, with neuroinflammation, oxidative stress and cholinergic dysfunction being few of the many changes. Due to complexity disease, current therapeutic strategies aim at multitargeted approach, often relying on combination substances versatile complementary effects. In present study, unique α-lipoic acid, citicoline, extracts leaves from olive tree green tea, vitamin D3, selenium an immune-supporting was tested in...
The red mullet ( Mullus barbatus Linnaeus, 1758) is a keynote species for the Bulgarian Black Sea ecosystem and fisheries; nevertheless, existing knowledge on population status very scarce. present study was intended to assess health adaptive potential of M. populations inhabiting waters Sea. Our findings revealed that are exposed variety anthropogenic environmental stressors. species’ assessed using representative genetic, morphological, biochemical chemical biomarkers from specimens...
Abstract Copper toxicity is associated with formation of reactive oxygen species, which are capable to oxidize proteins. The selective removal the latter by 20S proteasome considered an essential part cell antioxidant defense system. aim present study was investigate whether peptidase activities rat liver proteasomes were affected chronic (40 mg CuSO 4 /rat/daily drinking water for 2 weeks) and acute (20 mg/kg , s.c.) copper treatment. To evaluate role proteasome, its inhibitor MG132 also...