Small-scale photobioreactors (PBRs) in the inoculum stage were designed with internal (red or green) and external white LED light as an initial step of a larger-scale installation aimed at fulfilling integral biorefinery concept for maximum utilization microalgal biomass multifunctional laboratory. The specific growth rate Scenedesmus obliquus (Turpin) Kützing given cultural conditions was analyzed by using MAPLE software. For determination total polyphenols, flavonoids, chlorophyll “a” “b”,...

Sideritis scardica Griseb. and Clinopodium vulgare L., belonging to the Lamiaceae family, are rich in terpenoids phenolics exhibit various pharmacological effects, including antioxidant, anti-inflammatory anti-cancer activities. While memory-enhancing impacts of S. well documented, cognitive benefits C. remain unexplored. This study assessed potential effect on learning memory healthy scopolamine (Sco)-induced memory-impaired male Wistar rats, comparing it with effects scardica. Over a...

Pseudomonas aeruginosa is an opportunistic pathogen that causes nosocomial infections of the urinary tract, upper respiratory gastrointestinal central nervous system, etc. It possible to develop bacteremia and sepsis in immunocompromised patients. A major problem treatment development antibiotic resistance. Therefore, new preparations natural origin are sought, such as plant extracts, which phytocomplexes it practically impossible Geum urbanum L. (Rosacea) a perennial herb known for many...

Numerous studies reported that resveratrol (RVT) exhibits strong antioxidant and cytoprotective effects in brain pathologies, but its low solubility bioavailability limit therapeutic potential. Encapsulation of RVT nanoparticles offers a promising strategy to enhance effectiveness. The aim this study was evaluate the vitro cytoprotective, DNA protective, capacity resveratrol-loaded Pluronic (P123/F127) micelles. micellar (mRVT, water dispersion) pure (30% hydroethanolic solution) were...

The cholinergic neuronal loss in the basal forebrain and increasing brain oxidative stress are one of main features suffering from Alzheimer's disease. Marrubium vulgare (M. vulgare), commonly known as 'white horehound,' possesses a variety valuable properties, such antioxidative, anti-inflammatory, antidiabetic activities. Moreover, it neuromodulatory properties that could potentially impact short-term memory functions.

Background: The neurodegenerative process in Alzheimer’s disease, one of the most common types dementia worldwide, mostly affects cholinergic neurotransmitter system and, to a lesser extent, monoaminergic one. antioxidant acetylcholinesterase (AChE) and triple monoamine reuptake inhibitory activity Sideritis scardica (S. scardica) other species has already been reported. Objective: To investigate effects S. water extracts on learning memory processes, anxiety-like behavior, locomotor...

The difficult-to-heal wounds continue to be a problem for modern medicine. Chitosan and diosgenin possess anti-inflammatory antioxidant effects making them relevant substances wound treatment. That is why this work aimed study the effect of combined application chitosan on mouse skin model. For purpose, (6 mm diameter) were made mice’s backs treated 9 days with one following: 50% ethanol (control), polyethylene glycol (PEG) in ethanol, PEG (Chs), (Dg) chitosan, (ChsDg). Before first...

The wastewater from the distillation of rose oils is discharged directly into soil because it has a limited potential for future applications. aim present study was to determine in vitro chromatographic profile, redox-modulating capacity, and antineoplastic activity obtained by essential Bulgarian Rosa alba L., damascena Mill., gallica centifolia L. We applied UHPLC-HRMS analysis wastewaters, studied their metal-chelating Fe(III)-reducing ability, performed MTT assay evaluation cytotoxic...

The wastewater after rose oil distillation is usually discharged into the drainage systems and it represents a serious environmental problem. While being rich in polyphenols, which have beneficial biological activity application pharmaceutical industry, limited research has been carried out about of specific wastewaters per se. Wastewaters four Bulgarian oil-bearing roses Rosa damascena Mill., R. alba L., centifolia gallica L. exerted significant antioxidant good antiherpes simplex virus...

Abstract The present study aimed to investigate the effects of pentoxifylline (PTX) on carrageenan (CG)‐induced paw oedema and endogenous levels cell enzyme non‐enzyme antioxidants in rat liver, 4 24 h after CG injection. PTX (50 mg kg −1 , i.p.), administered 30 min before CG, decreased oedema, 2–4 administration. drug protected CG‐induced decrease glutathione (non‐enzyme antioxidant) had no effect CG‐unchanged activities superoxide dismutase, peroxidase (enzyme antioxidants)...

Alzheimer’s disease (AD), a progressive neurodegenerative disorder characterized by memory loss and cognitive functions decline, is leading cause for dementia currently ranked as the sixth foremost of death. As present, treatment AD symptomatic without convincing therapeutic benefits new, effective, agents are pursued. Due to massive cholinergic neurons decreased acetylcholine levels, cholinesterase inhibitors like galantamine, remain backbone pharmacological disease. In present study, using...

Background: The use of various herbal therapists as part traditional medicine in different parts the world, including Bulgaria, is due to knowledge accumulated over centuries by people about their valuable biological activities. In this study, we investigate extracts from widely used Bulgarian medicinal plants for ability prevent coronavirus infection cells testing mechanisms antiviral protection, polyphenol content, and redox-modulating capacity. Methods: influence on stage viral...

Alzheimer's disease (AD) is a neurodegenerative associated with memory impairment and other central nervous system (CNS) symptoms. Two myrtenal-adamantane conjugates (MACs) showed excellent CNS potential against models. Adamantane common pharmacophore for drug design, myrtenal (M) demonstrated neuroprotective effects in our previous studies. The aim of this study to evaluate the MACs' properties dementia.Scopolamine (Scop) was applied intraperitoneally Wistar rats 11 days, simultaneously...

Abstract In vivo effects of N ‐benzyloxycarbonyl (Cbz)‐Leu–Leu‐leucinal (MG132) on chymotryptic‐like (ChT‐L), tryptic‐like, and post‐glutamyl peptide hydrolytic‐like proteasome activities, protein oxidation, lipid peroxidation (LP), glutathione (GSH) level, as well the activity antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), peroxidase (GSH‐Px), glutathione‐reductase) in rat liver were studied. The possibility MG132 provoking formation free oxygen radicals was also assayed...

The pathogenesis of many diseases and different pathological conditions, including inflammation, is associated with excess production reactive oxygen species (ROS). present study aimed to investigate the effects antidepressant desipramine (DES) on carrageenan (CG)-induced as well endogenous levels cell enzyme non-enzyme antioxidants in rat liver spleen, 4 24 h after CG injection. intra-plantar injection into right hind paw resulted a time-dependent increase volume; maximum CG-induced edema...

Geraniol is a common component of essential oils various plant species and widely used in cosmetics, perfumery household products. In the present study, we investigated cytotoxic, genotoxic antioxidant activities different concentrations monoterpenoid geraniol its anti-cytotoxic anti-genotoxic potential against genotoxin N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) higher human lymphocyte test-systems frequently genotoxicity studies. The cytogenetic analysis did not show any inhibition cell...

An object of the present study was development liposomes loaded with medicine Veklury® (remdesivir) stabilized by electrostatic adsorption polysaccharide film formed from chitosans different physicochemical characteristics and hyaluronic acid. The functionalization structures achieved through inclusion an aptamer (oligonucleotide sequence) specific affinity to spike protein human coronavirus HCoV-OC43. hydrodynamic size, electrokinetic potential stability were evaluated at each step in...

Previous studies have shown that proteasome inhibitors exerted protective effects against ischemia/reperfusion injury (IRI) of brain, heart, kidney and intestine. The aim the present study was to investigate: (i) whether inhibitor MG132 protects rat liver IRI; (ii) modulates prooxidant/antioxidant status subjected warm IRI.The left lateral medial lobes (approximately 70% total volume) livers male Wistar rats were 30-min ischemia followed by 60-min reperfusion. Lactate dehydrogenase (LDH),...

Rosa alba L., also known as the white oil-bearing rose, has been cultivated in relatively small areas of Europe – predominantly Rose Valley Bulgaria. An increasing number studies vitro and vivo, including clinical studies, have demonstrated therapeutic efficacy rose oils recent years. However, little is about cytotoxic genotoxic potential phytocomplex oil extract derived from L. The aim present work was to investigate cytotoxicity clastogenic effects essential its main constituent geraniol,...

This study assessed phytochemical profile and antioxidant capacity of hydrosols, obtained by water-steam distillation Rosa alba L. damascena Mill. plants, grown in experimental field the Institute Rose Essential Oil Plants, Bulgaria. The identification hydrosols' compounds was performed using 7890A/5975 GC-MS system, total phenolic content (TPC) determined quantitatively Folin Ciocalteu reagent, with Gallic acid as standard both hydrosols concentration 0.3 % up to 15 were tested liposomal...

Numerous experimental studies suggest the potential for resveratrol (RVT) to be useful in Alzheimer’s disease treatment, but its low bioavailability limits application. This study aimed assess of resveratrol-loaded micelles as a neuronal delivery platform protect rats from scopolamine-induced memory impairment. Resveratrol was incorporated into Pluronic micelles, and effects micellar (mRVT) pure were compared model dementia male Wistar rats. Memory performance assessed by T maze test. The...

Alzheimer's disease (AD) has long proven to be a complex neurodegenerative disorder, with cholinergic dysfunction, oxidative stress, and neuroinflammation being just few of its pathological features. The complexity the requires multitargeted treatment covering many aspects. In present investigation, an arylhydrazone derivative 5-methoxyindole-2-carboxylic acid (5MeO), in vitro strong antioxidant, neuroprotective monoamine oxidase B-inhibiting effects, was studied scopolamine-induced...

Inhibitors of acetylcholinesterase (AChE) are used to treat many disorders, among which neurodegenerative upsets, like Alzheimer's disease (AD). One the limited licensed AChE inhibitors (AChEIs) as drugs is natural compound galantamine (Gal).As Gal a toxic compound, here we expose data about its four derivatives in hybrid peptide-norgalantamine molecules, have shown 100 times lower toxicity.Four newly synthesized been involved docking analysis made by Molegro Virtual Docker. Biological...