A5028089894- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Nerve injury and regeneration
- Melanoma and MAPK Pathways
- Laser Material Processing Techniques
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Computational Drug Discovery Methods
- Liver Disease Diagnosis and Treatment
- Curcumin's Biomedical Applications
- Axon Guidance and Neuronal Signaling
- Phytochemicals and Antioxidant Activities
- Nanoparticle-Based Drug Delivery
- Immune Response and Inflammation
- Laser Applications in Dentistry and Medicine
- Synthesis and biological activity
- Genital Health and Disease
- Nail Diseases and Treatments
- Genomics, phytochemicals, and oxidative stress
- Bacillus and Francisella bacterial research
- Tuberous Sclerosis Complex Research
- Autopsy Techniques and Outcomes
- Colorectal and Anal Carcinomas
Sofia University "St. Kliment Ohridski"
2013-2023
Lozenetz Hospital
2016-2023
Medical University of Sofia
2003-2016
University "St. Kliment Ohridski" - Bitola
2014
Oregano oil was successfully encapsulated into chitosan–albumin nanogel via emulsification and electrostatic gelation. The system characterized with a mean diameter around 26 nm, narrow size distribution (PDI = 0.242) approximately 40% encapsulation efficiency. incorporation of the confirmed by XRD FTIR analyses, dissolution enhanced after encapsulation. Furthermore, treatment Betacoronavirus 1 infected bovine kidney MDBK cells oregano oil-loaded (25 µg/mL) showed more than 50% protection...
The difficult-to-heal wounds continue to be a problem for modern medicine. Chitosan and diosgenin possess anti-inflammatory antioxidant effects making them relevant substances wound treatment. That is why this work aimed study the effect of combined application chitosan on mouse skin model. For purpose, (6 mm diameter) were made mice’s backs treated 9 days with one following: 50% ethanol (control), polyethylene glycol (PEG) in ethanol, PEG (Chs), (Dg) chitosan, (ChsDg). Before first...
BACKGROUND: Subungual exostosis is a relatively uncommon, benign osteocartilaginous tumor of the distal phalanx toes or fingers in young adults, considered as rare variant osteochondroma. Differential diagnoses include subungual verruca (viral wart), pyogenic granuloma, osteochondroma, amelanotic melanoma and glomus tumour. Misdiagnosis total onychodystrophy frequently occur result late treatment inadequate strategy. Dermoscopy could be useful technique, involved diagnostic process, although...
This study evaluated the in vitro antineoplastic and antiviral potential vivo toxicity of twelve extracts with different polarity obtained from herbaceous perennial plant Geum urbanum L. (Rosaceae). In cytotoxicity was determined by ISO 10993-5/2009 on bladder cancer, (T-24 BC-3C), liver carcinoma (HEP-G2) normal embryonic kidney (HEK-293) cell lines. The activity elucidated through assays clonogenicity, apoptosis induction, nuclear factor kappa B p65 (NFκB p65) activation total glutathione...
The emergence and spread of Mycobacterium tuberculosis strains resistant to many or all anti-tuberculosis (TB) drugs require the development new compounds both efficient with minimal side effects. Structure-activity-toxicity relationships such novel, structurally diverse must be thoroughly elucidated before further development. Here, we present aroylhydrazone (3a 3b) regarding their: (i) acute subacute toxicity in mice; (ii) redox-modulating vivo vitro capacity; (iii) pathomorphology liver,...
Tumours of the nail bed are rare. Squamous cell carcinoma is most frequent among them. Chronic infection, chemical or physical trauma/microtrauma, genetic disorders such as congenital ectodermal dysplasia, radiation, tar, arsenic exposure to minerals, sun exposure, immunosuppression, and previous HPV infection have all been discussed etiologic factors. The diagnosis often delayed because variety clinical manifestations, resembling benign common infectious processes. Rapidly growing...
To evaluate the safety profile of cationic micelles, based on triblock copolymer poly(dimethylaminoethyl methacrylate)-poly(e-caprolactone)-poly(dimethylaminoethyl methacrylate) (PDMAEMA9- PCL70-PDMAEMA9), effects empty (PM) and curcumin loaded micelles (PM-Curc) nonenzyme induced lipid peroxidation (LPO) in vitro, hemolytic activity morphological changes some organs after repeated intraperitoneal administration vivo were studied. induce LPO, rat liver microsomes incubated with a solution...
Tuberculosis (TB) remains a widespread infectious disease and one of the top 10 causes death worldwide. Nevertheless, despite significant advances in development new drugs against tuberculosis, many therapies preventive measures do not lead to expected favorable health results for various reasons. The aim this study was evaluate acute sub-acute toxicity oxidative stress two selected nitrofuranyl amides with high vitro antimycobacterial activity. In addition, molecular docking studies were...
Coronaviruses (CoVs) belong to the group of enveloped positive-sense single-strand RNA viruses and are causative agents respiratory, gastro-intestinal, central nervous systems diseases in many host species, i.e., birds, mammals, humans. Beta-CoVs revealed a great potential cross barrier between species by causing three epidemics/pandemics among humans 21st century. Considering urgent need for powerful antiviral decontamination, prevention, treatment BCoV infections, we turned our attention...
Recent evidence indicates that some thymic cells of developing and adult laboratory animals express the neurotrophin NGF its low-affinity p75 NTR high-affinity TrkA receptor. Less is known as to whether thymus aged humans these markers. We hypothesize presence distribution immunopositive for receptors undergo alterations during involution human thymus. Specimens from normal thymuses old individuals were obtained autopsy surgery cases, examined immunocytochemically at light transmission...
Summary Basal cell carcinoma (BCC) is the most frequent non-melanoma skin cancer. Only 5-15% of BCC cases can be found in patients aged 20-40 years (so-called early onset). The onset characterized by active and aggressive tumour growth, clinically presenting as a morpheaform, locally infiltrating or recurrent BCC. Despite advances study pathogenesis this tumour, surgery remains used, effective suitable treatment modality. We describe case 39-year-old woman who developed an nasolabial fold....
Lasers can significantly advance medical diagnostics and treatment. At high power, they are typically used as cutting tools during surgery. For lasers that knifes, radiation wavelengths in the far ultraviolet near infrared spectral regions favored because tissue has contents of collagen water. Collagen an absorption peak around 190 nm, while water is 3,000 nm. Changing wavelength across will result significant differences laser interactions. Tunable could optimize interaction for ablation...
Cutaneous T-cell lymphoma (CTCL) is a rare form of cancer with local as well systemic manifestations. Concomitant bacterial infections increase morbidity and mortality rates due to impaired skin barrier immune deficiency. In the current study, we demonstrated that in vitro anti-lymphoma potential erufosine diminished by TWIST1 expression micellar curcumin substantially increases its antineoplastic activity. Pharmacokinetic analysis showed (MCRM) used our study was characterized low zeta...
Keratinocyte skin cancers, including basal cell carcinoma (BCC) and squamous (SCC), are the most common cancer occurring in people with fair skin, worldwide. Despite all known triggers, several suggested contributors still investigated. We will focus our attention on personal history of previous cancers radiation exposure as occupational risk factors, presented case. report a patient, multiple BCCs, subsequent occurrence SCC photo-exposed area face, we want to emphasize importance strict...
Geum urbanum L. is a medicinal plant used from ancient time against gastro-intestinal disorders, bleeding and inflammation of mucous membranes, gums (gingivitis), etc. In our previous works, we demonstrated the antibacterial antioxidant properties ethyl acetate (EtOAc) extracts in vitro. The aim this study was to evaluate possibility EtOAc fraction aerial parts provoke acute subacute toxicity by its internal daily administration (per os) healthy H- albino male female mice. We three...
We report two new cases of glomus coccygeum in pilonidal sinus excision specimens. The positive expression cells for SOX10 is used the first time. a useful immunohistochemical marker identifying this microanatomical structure, confirming diagnosis and may help differential diagnosis. are probably neural crest-derived from multipotent Schwann cell precursors.