A5024642846- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Cardiac electrophysiology and arrhythmias
- Atmospheric chemistry and aerosols
- Aquatic Ecosystems and Phytoplankton Dynamics
- Marine and coastal ecosystems
- Cardiac Arrhythmias and Treatments
- Anesthesia and Sedative Agents
- Analytical Methods in Pharmaceuticals
- Effects and risks of endocrine disrupting chemicals
- Atrial Fibrillation Management and Outcomes
- Biosimilars and Bioanalytical Methods
- Metabolism and Genetic Disorders
- Marine Toxins and Detection Methods
- Chronic Lymphocytic Leukemia Research
- Pesticide Residue Analysis and Safety
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Aquatic Ecosystems and Biodiversity
- Biocrusts and Microbial Ecology
- Cancer Treatment and Pharmacology
- Pharmacological Effects and Assays
- Analytical Chemistry and Sensors
- CO2 Sequestration and Geologic Interactions
- Wastewater Treatment and Reuse
Arcadis (United States)
2021-2025
Oak Ridge Institute for Science and Education
2017-2021
Oak Ridge Associated Universities
2017-2021
Research Triangle Park Foundation
1990-2019
Environmental Protection Agency
2017-2019
Eötvös Loránd University
2019
North Carolina State University
2014-2017
Hôpital Edouard Herriot
1985-1990
Université Claude Bernard Lyon 1
1983-1989
Chirurgische Universitätsklinik Heidelberg
1981
Per- and polyfluoroalkyl substances (PFASs) are highly persistent synthetic chemicals, some of which have been associated with cancer, developmental toxicity, immunotoxicity, other health effects. PFASs in grease-resistant food packaging can leach into increase dietary exposure. We collected ∼400 samples contact papers, paperboard containers, beverage containers from fast restaurants throughout the United States measured total fluorine using particle-induced γ-ray emission (PIGE)...
Landfills are the final stage in life cycle of many products containing per- and polyfluoroalkyl substances (PFASs) their presence has been reported landfill leachate. The concentrations 70 PFASs 95 samples leachate were measured a survey U.S. landfills varying climates waste ages. National release was estimated by coupling for 19 where more than 50% had quantifiable concentrations, with climate-specific estimates annual volumes. For 2013, total volume generated to be 61.1 million m3, 79%...
Discarded carpet and clothing are potential sources of per- polyfluoroalkyl substances (PFASs) in landfill leachate, but little is known about their release when disposed landfills. The concentrations 70 PFASs the aqueous phase anaerobic model reactors filled with or were monitored under biologically active abiotic conditions. For carpet, total PFAS was greater live than reactors, an average 8.5 nmol/L 0.62 after 552 days, respectively. Release primarily due to 5:3 fluorotelomer carboxylic...
A wide variety of consumer products that are treated with poly- and perfluoroalkyl substances (PFASs) related formulations disposed in landfills. Landfill leachate has significant concentrations PFASs acts as secondary point sources to surface water. This study models how enter using four laboratory-scale anaerobic bioreactors filled municipal solid waste (MSW) operated over 273 days. Duplicate reactors were monitored under live abiotic conditions evaluate influences attributable biological...
Microcystins (MCs) are common cyanobacterial toxins that occur in freshwaters worldwide. Only two of the >200 MC variants have been tested for potential toxicity after oral exposure. This paper reports on 10 different congeners identified algal blooms, microcystin-LR (MCLR), MCLA, MCLF, MCLW, MCLY, MCRR, [Asp3]MCRR, [Asp3,Dhb7]MCRR, MCWR, and MCYR single administrations to BALB/c mice. In a preliminary MCLR dose-response study 3 9 mg/kg doses, ≥5 induced clinical changes, increased serum...
Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) was coupled with high-resolution accurate-mass-mass spectrometry (HRAM-MS) to image perfluoroalkyl and polyfluoroalkyl substances (PFAS) in stabilized soil cores. Previous field-scale research demonstrated a substantial decrease the leachability of PFAS following application situ stabilization solidification (S/S) an aqueous film-forming foam (AFFF) source zone. While this previous study empirically confirmed...
The polyfluorinated alkyl substance (PFAS) Nafion BP2 (1,1,2,2-tetrafluoro-2-[1,1,1,2,3,3-hexafluoro-3-(1,1,2,2-tetrafluoroethoxy)propan-2-yl]oxyethane-1-sulfonic acid) has been detected in surface and ground water, as well the blood of people living near PFAS manufacturing facilities. Given that very little is known about potential toxicity safe exposure levels have not yet determined, we performed a benchmark dose analysis phenotypic genomic effects mice. Male female Balb-c mice were...
Per- and polyfluoroalkyl substances (PFAS) are incorporated into an ever-increasing number of modern products inevitably enter the environment ultimately human bodies. Herein, we show that chemical ionization mass spectrometry with iodide reagent ion chemistry is a useful technique for detection fluorotelomer alcohols (FTOHs) other oxygenated PFAS, including per- polyfluoro carboxylic acids such as hexafluoropropylene oxide dimer acid. This offers direct, high-time resolution measurement...
A field-scale validation is summarized comparing the efficacy of commercially available stabilization amendments with objective mitigating per- and polyfluoroalkyl substance (PFAS) leaching from aqueous film-forming foam (AFFF)-impacted source zones. The scope this work included bench-scale testing to evaluate multiple application concentrations mitigate PFAS leachability execution soil mixing in an AFFF-impacted fire-training area nearly 2.5 years post-soil monitoring validate reductions...
Hazardous algal blooms can generate toxic compounds with significant health impacts for exposed communities. The ubiquitous class of toxins known as microcystins exhibits heterogeneity in its peptide structure, which has been minimally studied, given the impact this on hydrophobicity, acid/base character and related environmental fate effects. Octanol-water partition coefficients microcystin congeners MCLR, MCRR, MCLY, MCLF, MCLA were calculated over an environmentally physiologically...
Microcystins are common freshwater cyanobacterial toxins that affect liver function. The toxicities of five microcystin congeners (microcystin-LA (MCLA), MCLR, MCLY, MCRR, and MCYR) commonly observed in harmful algal blooms (HABs) were evaluated BALB/c mice after a single oral administration doses ranging from those no adverse effect levels (NOAELs) to lowest (LOAELs). Animals monitored for changes behavior appearance, euthanized 24 h dosing. Test endpoints included clinical changes,...
Fire suppression systems are known to be impacted with residual, entrained per- and polyfluoroalkyl substances (PFASs) because of historical use aqueous film forming foam (AFFF) fluoroprotein foam. Amphiphilic PFASs aggregate at liquid:solid interfaces creating a hydrophobic layer which reduces the effectiveness water remove PFAS from layered surfaces. When fire transitioned fluorine free (F3) without appropriate cleaning, residual associated surfaces system can contaminate replacement F3....
Cylindrospermopsin (CYN) is a toxin associated with numerous species of freshwater cyanobacteria throughout the world. It postulated to have caused an episode serious illnesses in Australia through treated drinking water, as well lethal effects livestock exposed water from farm ponds. Toxicity included indicative both hepatic and renal dysfunction. In humans, symptoms progressed initial hepatomegaly, vomiting, malaise acidosis hypokalemia, bloody diarrhea, hyperemia mucous membranes....
Microcystins are toxins produced by many cyanobacteria species, which often released into waterways during blue-green algal blooms in freshwater and marine habitats. The consumption of microcystin-contaminated water is a public health concern as these recognized tumor promoters hepatotoxic to humans animals. A method confirm human exposures microcystins needed; therefore, our laboratory has developed an immunocapture liquid chromatography tandem mass spectrometry (LC–MS/MS) targeting the...