A5005618541- Cystic Fibrosis Research Advances
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Health Systems, Economic Evaluations, Quality of Life
- Medication Adherence and Compliance
- Adolescent and Pediatric Healthcare
- Pharmaceutical studies and practices
- Asthma and respiratory diseases
- Pneumonia and Respiratory Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Esophageal and GI Pathology
- Behavioral Health and Interventions
- Child Nutrition and Feeding Issues
- Healthcare Policy and Management
- Pediatric health and respiratory diseases
- Nosocomial Infections in ICU
- Iron Metabolism and Disorders
- Simulation Techniques and Applications
- Delphi Technique in Research
- Geriatric Care and Nursing Homes
- demographic modeling and climate adaptation
- Mobile Health and mHealth Applications
- Economic and Environmental Valuation
Sheffield Teaching Hospitals NHS Foundation Trust
2014-2025
University of Sheffield
2014-2023
Northern General Hospital
2012-2022
University of Edinburgh
2011
Recurrent pulmonary exacerbations lead to progressive lung damage in cystic fibrosis (CF). Inhaled medications (mucoactive agents and antibiotics) help prevent exacerbations, but objectively measured adherence is low. We investigated whether a multi-component (complex) self-management intervention support would reduce exacerbation rates over 12 months.Between October 2017 May 2018, adults with CF (aged ≥16 years; 19 UK centres) were randomised the (data-logging nebulisers, digital platform...
Among adults with cystic fibrosis (CF), medication adherence is low and reasons for are poorly understood. Our previous exploratory study showed that stronger 'habit' (ie, automatically experiencing an urge to use a nebuliser) was associated higher nebuliser adherence. We performed secondary analysis of pilot trial data (n=61) replicate the earlier determine whether habit-adherence association exists in other cohorts CF. In this study, high adherers also reported habit compared adherers....
Accurate reporting of adherence to inhaled therapies in adults with cystic fibrosis: methods calculate normative Zhe Hui Hoo,1,2 Rachael Curley,1,2 Michael J Campbell,1 Stephen Walters,1 Daniel Hind,3 Martin Wildman1,2 1School Health and Related Research (ScHARR), University Sheffield, 2Sheffield Adult Cystic Fibrosis Centre, Northern General Hospital, 3Sheffield Clinical Trials Unit, UK Background: Preventative treatments fibrosis will only be effective maintaining lung health if used...
Patient activation refers to patients' knowledge, skills, and confidence in self-managing health conditions. In large cross-sectional studies, individuals with higher patient are observed have better outcomes the assumption that they more engaged self-management. However, association between objectively measured self-care indicators can be inconsistent. This research investigated role of as by UK Activation Measure (PAM-13) adults Cystic Fibrosis (CF). The aims were twofold: explore how CF...
Objectives: Adherence to nebulised treatment is typically low among people with cystic fibrosis (CF). This study sought identify factors differentiating high or nebuliser adherence patterns (i.e. ≥80% <50% of all treatments over one year) adults CF.Design: A mixed methods cross-sectional exploratory comparison and adherers medications.Methods: Of 36 eligible invited from a UK CF centre, 20 were recruited (10 high, 10 adherers). was objectively measured using electronic data capture....
Pseudomonas aeruginosa status influences cystic fibrosis (CF) clinical management but no 'gold standard' definition exists. The Leeds criteria are commonly used may lack sensitivity for chronic P. aeruginosa. We compared clinicians' decision with the in three adult CF centres. Two independent prospective datasets (Sheffield dataset, n = 185 adults; ACtiF pilot 62 adults from two different centres) were analysed. Clinicians involved deciding blinded to study objectives. considered more have...
Cystic fibrosis (CF) health care professionals recognize the need to motivate people with CF adhere nebulizer treatments, yet little is known about how best achieve this. We aimed produce motivational posters support adherence by using social marketing involving in development of those posters.The Sheffield multidisciplinary team produced preliminary ideas that were elaborated upon semi-structured interviews among explore barriers and facilitators use nebulized therapy. Initial themes poster...
BackgroundCentre-level data for relevant health outcomes are summarised in the UK CF registry annual report as caterpillar plots and funnel with aim of using to drive quality improvement.These reports publically available
Background: The purpose of using preventative inhaled treatments in cystic fibrosis is to improve health outcomes. Therefore, understanding the relationship between adherence treatment and outcome crucial. Temporal variability, as well absolute magnitude affects outcomes, there likely be a threshold effect We therefore propose pragmatic algorithm-based clustering method objective nebulizer data better understand this relationship, potentially, guide clinical decisions. Methods cluster data:...
Habit, a psychological process that automatically generates urges to perform behavior in associated settings, is potentially an important determinant of medication adherence. Habit challenging measure because, as construct, it cannot be directly observed. We describe method using routinely available objective adherence data from electronic capture (EDC) generate behavior-based index habit and demonstrate how this can applied.Our proposed "frequency context" measure. It estimates...
Background People with cystic fibrosis frequently have low levels of adherence to inhaled medications. Objectives The objectives were develop and evaluate an intervention for adults improve their medication. Design We used agile software methods online platform. mixed a behaviour change delivery by interventionist. These integrated become the CFHealthHub intervention. undertook feasibility study consisting pilot randomised controlled trial process evaluation in two centres. evaluated using...
<ns4:p><ns4:bold>Background:</ns4:bold> Inhaled medications for cystic fibrosis (CF) are effective but adherence is low. Clinicians find it difficult to estimate how much treatment people with CF (PWCF) take, whilst objective measurement demonstrates that patients poorly calibrated a tendency over-estimate actual adherence. The diagnostic approach PWCF deteriorating clinical status and very low likely be different the patient optimal Access data in routine consultations could help overcome...