A5107881881- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- Management of metastatic bone disease
- RNA modifications and cancer
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Oral health in cancer treatment
- Hernia repair and management
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Cancer Treatment and Pharmacology
- Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Maternal and Perinatal Health Interventions
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
Indira Gandhi Medical College
2012-2024
Himachal Pradesh University
2022-2024
Sir Ganga Ram Hospital
2007-2024
All India Institute of Medical Sciences Bhopal
2022-2023
Serum Institute of India (India)
2020-2023
Queen Elizabeth Hospital Birmingham
2020
Rajendra Hospital
2020
Bristol-Myers Squibb (United States)
2015-2018
Barts Health NHS Trust
2015-2017
Institute of Post Graduate Medical Education and Research
2014
To assess new metrics of tumor-size response to predict overall survival (OS) in colorectal cancer (CRC) Western and Chinese patients.Various were estimated using longitudinal tumor size models data from two phase III studies that compared bevacizumab plus chemotherapy versus as first-line therapy (n = 923) 203) patients with CRC. Baseline prognostic factors estimates assessed multivariate OS. Predictive performances the by simulating multiple replicas studies.Time growth (TTG) was best...
Abstract Despite the availability of various diagnostic procedures, a tissue biopsy is still indispensable for routine diagnosis lung cancer. However, inaccurate diagnoses can occur, leading to inefficient cancer management. In this context, use circulating micro RNA s (mi s) may serve as tools liquid biopsies, and biomarkers better understand molecular mechanisms involved in progression We identified miR‐590‐5p potential prognostic marker non‐small cell ( NSCLC ). were able detect mi blood...
Dysregulated expression profiles of microRNAs (miRNAs) have been observed in several types cancer, including non-small cell lung cancer (NSCLC); however, the diagnostic and prognostic potential circulating miRNAs NSCLC remains largely undefined. Here we found that miR-320a was significantly down-regulated (~5.87-fold; p < 0.0001) patients ( n = 80) compared to matched control plasma samples from healthy subjects 80). Kaplan-Meier survival analysis revealed with lower levels had...
BACKGROUND: Robotic technique of surgery allows surgeons to perform complex procedures in difficult-to-access areas the abdominal/pelvic cavity (eg, radical prostatectomy and hysterectomy) with improved access precision approach. At same time, automated techniques efficiently deliver propofol total intravenous anesthesia (TIVA) lower anesthetic consumption. As both above are likely bring benefit patients, it is imperative explore their effect on postanesthesia recovery. Quality Recovery-15...
Background: VPM1002BC is a modified mycobacterium Bacillus Calmette Guérin (BCG) for the treatment of non-muscle invasive bladder cancer (NMIBC). The genetic modifications are expected to result in better immunogenicity and less side effects. We report on patient safety immunology first intravesical application human.Methods: Six patients with BCG failure received 6 weekly instillations VPM1002BC. Patients were monitored adverse events (AE), excretion cytokines, respectively.Results: No DLT...
Eosinophilic granuloma is a variety of histiocytosis-X with unknown etiology. occurs as single or multiple lesions bone destruction. It seen more commonly in children young adults although it may be found at all ages. Other sites like the lung and gastrointestinal tract also affected. This rare case eosinophilic which presented frontal headache. The radiographic cytological findings were characteristic disease.
Oral cancer is the sixth most common among Indian males and third females. Early detection of oral cancers makes them more amenable to treatment allows greatest chance cure. Lack awareness health care providers significant factor in delaying diagnosis cancer. So aim study was assess knowledge, attitude practices undergraduate medical students Indira Gandhi Medical College, Shimla, India.A cross-sectional questionnaire conducted 186 between fifth years Shimla. The consisted 15 questions, five...
Categorizations of best response observed at week 8 (between 3 and 14) first-line treatment in two studies bevacizumab plus chemotherapy Western (878 patients) Chinese (198 patients with non-small cell lung cancer were assessed together baseline prognostic factors multivariate parametric models to predict overall survival (OS) progression free (PFS). Predictive performances the by simulating multiple replicates studies. Disease control rate (DCR) was categorization OS PFS. In model, DCR...
The unprecedented success of immuno-oncology (I-O) agents targeting the cytotoxic T lymphocyte-associated antigen 4 and programmed death-1/programmed death-ligand 1 pathways has stimulated rapid development other I-O against novel immune targets. Bristol-Myers Squibb designed a phase II platform trial, Fast Real-time Assessment Combination Therapies in Immuno-ONcology (FRACTION) Program, to efficiently identify promising combinations for patients with specific malignancies. concept study...
Radiotherapy is a very effective treatment modality for pelvic malignancies such as carcinoma of the cervix. However, it quite common chronic radiation proctitis (CRP) to manifest after radical radiotherapy. CRP source significant morbidity, and there lack modalities. There also exists general guidelines on management CRP.To assess benefit from 4% formalin application Grade >2 among patients previously treated with radiotherapy cervical carcinoma.This retrospective descriptive study involved...
Induction of labour (IOL) in maternity care is often not an area priority services, which results protracted delays, a poor patient experience, and complaints. Caesarean section (CS) rates among women undergoing IOL at this inner city district general hospital were noted to be higher than other units nationwide. We collected pre post-intervention data the following outcome measures: time taken administer prostaglandin after arrival, achieve established labour, mode delivery, user...
Introduction: Breast cancer treated with adjuvant hypofractionation radiotherapy two different techniques, i.e., volumetric-modulated arc therapy (VMAT) and intensity-modulated radiation (IMRT) their effects in terms of loco-regional control adverse cutaneous, pulmonary, cardiac outcomes are compared. Materials methods: This is a prospective non-randomized observational study. VMAT IMRT plan for 30 breast patients who were supposed to receive prepared using schedule. The plans dosimetrically...
Palliative radiotherapy aims at symptom alleviation and improvement of quality life. It may be effective in conferring a reasonable quantum local control, as well possibly prolonging survival on the short term. However, there can rare instances where long-term survival, or even cure, results from palliative radiotherapy, which mostly uses sub-therapeutic doses.To categorize characterize patients with and/or cure after radiotherapy.This study is retrospective analysis hospital records treated...
Background: Surgical fixation using intramedullary headless screws (IHS) is a relatively new technique for metacarpal fracture repair. However, there are very few studies investigating the outcomes of this procedure. We present surgical and functional consecutive series 30 fractures treated by single surgeon over 2.5-year period IHS. Methods: retrospectively reviewed records in 27 patients who underwent IHS from March 2016 to October 2018. There were 29 neck 1 was head. All procedure...
The study is to evaluate the difference between outcomes of two high-dose-rate fractionation schedules in treatment intracavitary brachytherapy (ICBT) cervical cancer.A retrospective analysis 163 cancer patients was completed. All received external beam radiotherapy (EBRT) whole pelvis with concurrent weekly chemotherapy, followed by ICBT either 7 Gy per fraction three fractions (arm A) or 9 B). Median follow-up 19 months. were compared terms 2-year actuarial local control, disease-free...
Recently, the one-week hypofractionated radiotherapy regimen (26 Gy in 5 fractions) for adjuvant breast has been shown to be non-inferior other regimens (15-16 fractions). The aim of present dosimetric study is compare Intensity Modulated Radiotherapy (IMRT), Volumetric Arc Therapy (VMAT) and 3D Conformal (3D-CRT) a radiotherapy.
Altered expression of many E2F family members have been reported in various human cancers. In this study, we investigated the role non-synonymous single nucleotide polymorphisms (rs3213172 C/T, rs3213173 and rs3213176 G/A) gene E2F1 with cervical cancer.A total 181 samples including 90 cancer patients 91 healthy controls were genotyped. The genotype frequencies these collected determined by either PCR-RFLP or PCR-ARFLP methods. SHEsis software was used to analyze haplotypes.Statistically...
Introduction: Zinc deficiency is very much prevalent among pregnant women in developing countries. required to maintain normal structure and function of multiple enzymes including those that are involved foetal growth. increases risk baby being born preterm, low birth weight, small for gestational age (SGA). Aims Objectives: To compare serum zinc levels babies with respect appropriate (AGA). Material Methods: Out total 200 newborn, hundred SGA newborn comprised the study group AGA control...