A5100395192- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinopathy of Prematurity Studies
- Corneal Surgery and Treatments
- Cardiac Imaging and Diagnostics
- Retinal Imaging and Analysis
- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Radiation Dose and Imaging
- Bone and Joint Diseases
- Intraocular Surgery and Lenses
- Photonic Crystals and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Retinal Development and Disorders
- Connective tissue disorders research
- Ocular Surface and Contact Lens
- Liver Disease Diagnosis and Treatment
- Electromagnetic Scattering and Analysis
- Advanced X-ray and CT Imaging
- Ultrasound in Clinical Applications
- SARS-CoV-2 detection and testing
- Optical Coatings and Gratings
- Topological and Geometric Data Analysis
Fudan University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Eye & ENT Hospital of Fudan University
2020-2025
Shanghai Clinical Research Center
2020-2025
Shanghai Eye Disease Prevention & Treatment Center
2022-2025
Shanghai Jiao Tong University
2023-2024
Nanjing University of Chinese Medicine
2013-2024
Biotechnology Research Center
2023
Mackay Memorial Hospital
2023
Chinese University of Hong Kong
2022
Objective To evaluate the longitudinal changes in effective optical zone (EOZ) following hyperopic keratorefractive lenticule extraction (KLEx) and investigate factors influencing EOZ.
To explore the short-term effects of atropine 0.01% on structure and vasculature choroid retina in myopic Chinese children.This study was a single-center randomized clinical trial. A total 40 subjects with myopia < - 6.0 D were enrolled to receive once nightly regular single-vision lenses or simply wear at an allocation ratio 1:1. Follow-up visits planned 1 month 3 months. Choroidal thickness (ChT) obtained by optical coherence tomography (OCT). Retinal vessel density (RVD), retinal (RT),...
Neurite orientation dispersion and density imaging (NODDI) is a new diffusion MRI technique that has rarely been applied for glioma grading. The purpose of this study was to quantitatively evaluate the diagnostic efficiency NODDI in tumour parenchyma (TP) peritumoural area (PT) grading gliomas detecting isocitrate dehydrogenase-1 (IDH-1) mutation status. Forty-two patients (male: 23, female: 19, mean age: 44.5 y) were recruited underwent whole brain examination. Intracellular volume fraction...
Background: HIV/AIDS remains a major global public health challenge despite significant progress in treatment. New infections and HIV-related deaths persist, fueled by disparities prevention care access. Purpose: This review synthesizes recent advances across key domains - from vaccine development to novel treatments omics approaches – that collectively hold promise for ending the pandemic. Main body: Multiple innovative HIV platforms are now early-phase trials, including mRNA vaccines as...
The measurement and simulation of corneal lenticular curvature radii using a single swept-source biometry device enables more thorough evaluation the shape refractive power cornea lens during emmetropization or myopia progression in children.This study aimed to evaluate distribution characteristics parameters Chinese children with explored their association other ocular components.In this cross-sectional study, all biometric were measured Zeiss IOLMaster 700 Biometry. Simulations implemented...
Background: Sepsis remains a critical global health challenge with high mortality. This review summarizes current understanding of the intricate molecular mechanisms governing sepsis pathogenesis and highlights emerging therapeutic approaches. Main body abstract: The dysregulated immune response in sepsis, involving both excessive inflammation immunosuppression, is mediated through cytokines, pattern recognition receptors, disturbances cell function. Endothelial dysfunction, coagulation...
Abstract Background To describe the clinical and optical coherence tomography (OCT) features of focal choroidal excavation in Chinese patients. Methods Retrospectively, thirty-seven eyes (in 31 patients) that demonstrated on spectral-domain OCT were collected. Their characteristics other also collected analyzed. Results In total, 42 excavations identified patients, including 25 unilateral 6 bilateral (37 eyes). The abnormal changes these with more prominent at outer part neuro-retina,...
The purpose of the study was to investigate effect artificial light with different spectral composition and distribution on axial growth in guinea pigs. Three-week-old pigs were randomly assigned groups exposed natural light, low color temperature light-emitting diode (LED) two full spectrum lights (E Julia light) blue filtered same intensity. Axial lengths pigs’ eyes measured by A-scan ultrasonography prior experiment every 2 weeks during experiment. After exposure for 12 weeks, retinal...
Children respond differently to atropine treatment, and predicting patient factors associated with better myopia control is important. Therefore, we aimed evaluate related progression in Chinese children treated 0.01%. This retrospective study included 133 who were administered 0.01% eyedrops every night for 1 year. Enrolled examined at follow-up visits 3 6 months, The primary outcome was clinically significant (over a -0.75 diopter (D) increase spherical equivalent (SE)). Multivariate...
To investigate the refractive and ocular biometric characteristics of children with mild hyperopia distinguish between non-myopic pseudomyopic eyes before cycloplegia.
Little is known about changes in astigmatism during atropine treatment. We aimed to explore the effects of 0.01% eye drops on both spherical and cylindrical refractive errors myopic children.Children aged 6-14 years with myopia ≥ -6.00 D < -0.50 D, total > -2.00 at least one were enrolled. Subjects randomised either receive once nightly single-vision lenses or simply wear followed up 3-month intervals. Cycloplegic refraction axial length measured. The magnitude direction (TA), corneal (CA),...
Artificial light can affect eyeball development and increase myopia rate. Matrix metalloproteinase 2 (MMP-2) degrades the extracellular matrix, induces its remodeling, while tissue inhibitor of matrix MMP-2 (TIMP-2) inhibits active MMP-2. The present study aimed to look into how refractive expression TIMP-2 in guinea pigs' remodeled sclerae are affected by artificial with varying spectral compositions. Three weeks old pigs were randomly assigned groups exposed five different types light:...
Long noncoding RNAs (lncRNAs) play a key role in the occurrence and progression of myopia. However, function lncRNAs retinal ganglion cells (RGCs) pathogenesis myopia is still unknown. The aim our study was to explore lncRNA-mediated competing endogenous RNA (ceRNA) network RGCs during development myopia.RNA sequencing performed analyze lncRNA mRNA expression profiles between guinea pigs with form-deprived (FDM) normal control pigs, related ceRNA networks were constructed. Then, potentially...
Jerusalem artichoke (Helianthus tuberosus L.) polysaccharide (JAP) is a chain composed of D-fructose connected by β (1-2) glycosidic bonds, which kind inulin. This study evaluated the anti-respiratory syncytial virus (RSV) activity JAP in vivo and vitro. To investigate its antiviral activity, an MTT assay, q-PCR, enzyme-linked immunosorbent assay (ELISA), lung histological observation were performed. The results showed that anti-RSV vitro with half maximal inhibitory concentration (IC50)...
Background . To explore the effect of atropine 0.01% on accommodation functions and pupil size for safely effectively controlling myopia in Chinese children. Methods This was a single-center randomized clinical trial. 63 participants with at least −0.50 D astigmatism ≤−2.50 were enrolled to receive once nightly regular single-vision lenses or wear lenses, an allocation ratio 3 : 2. Primary outcomes included changes functions, diameter, distant near best-corrected visual acuity (BCVA),...
Abstract Purpose The morphological changes in the cornea and crystalline lens have not been closely evaluated after administration of atropine 0.01%. This study aims to evaluate radii curvature refractive power myopic eyes during 0.01% treatment. Methods Children aged 6–14 years with myopia <−6.0 D were randomized receive once nightly single vision lenses or simply wear lenses. Ocular biometric parameters measured using IOLMaster 700 biometry corneal lenticular simulated a customized...
Aim: To evaluate the effects of 0.5% tropicamide on anterior segment parameters with CASIA2 imaging device in emmetropic, myopic, and hyperopic eyes. Methods: In this prospective study, a total 125 subjects (34 emmetropic subjects, 57 myopic 34 subjects) at Shanghai Eye ENT Hospital Fudan University were recruited from June 2021 to September 2021. The solution was used once every 5 min times for cycloplegia. recorded by before after Changes compared among three refractive groups. Results:...
To explore the influence of artificial luminous environment and preventive function traditional Chinese medicine (TCM) intervention based on "Theory yin-yang clock" myopia.A total 45 New Zealand young rabbits were randomly divided into 5 groups, 9 for each group. Control group was exposed in natural light. Fluorescent full spectrum fluorescent light light, which basis TCM added with "Rizhong Yinyang Formulas", respectively. Optical parameters measured different lights serum retinal dopamine...