A5006640593- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- interferon and immune responses
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Advanced Memory and Neural Computing
- Animal Disease Management and Epidemiology
- Physical Unclonable Functions (PUFs) and Hardware Security
- Mycotoxins in Agriculture and Food
- Neuroscience and Neural Engineering
- Poxvirus research and outbreaks
- Toxin Mechanisms and Immunotoxins
- Genetic and phenotypic traits in livestock
- Immune Cell Function and Interaction
- Plant Toxicity and Pharmacological Properties
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- Ginseng Biological Effects and Applications
- Herpesvirus Infections and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Plant and Fungal Interactions Research
Fujian Agriculture and Forestry University
2024
Hohai University
2023
South China Agricultural University
2014-2022
Tufts University
2018
Jean Mayer Human Nutrition Research Center on Aging
2018
University of Miami
2018
Atypical porcine pestivirus (APPV) have been detected in swine herds from the USA, Germany, Netherlands, Spain and most recently Austria, suggesting a wide geographic distribution of this novel virus. Here, for first time, we reported APPV infection China. Newborn piglets two separate Guangdong province were found showing typical congenital tremors July August 2016. RT-PCR, sequencing phylogenetic analysis showed occurred. Phylogenetic that Chinese strains, GD1 GD2, formed independent branch...
From June to July 2017, six Seneca Valley virus (SVV) strains were isolated from swine herds exhibiting SVV-associated porcine idiopathic vesicular disease (PIVD) in Guangdong province, China. Complete genomic sequences of these newly identified genetically and phylogenetically analysed. The results revealed that SVV closely related USA/GBI29/2015 notably distinct all previous Chinese strains, indicating the reemergence new province.
H9N2 avian influenza virus (AIV) becomes the focus for its ability of transmission to mammals and as a donor provide internal genes form new epidemic lethal viruses. Residue 627 in PB2 has been proven virulence factor mice, but detailed data inflammation difference between strains with site mutation is still unclear. The inflammasome NLRP3 recently reported cellular machinery responsible activation inflammatory processes plays an important role during development caused by infection. In this...
Abstract MicroRNAs (miRNAs) play key roles in the regulation of gene expression during multiple physiological processes, including early development, differentiation, and ageing. However, their involvement age‐related thymic involution is not clear. In this study, we profiled global transcriptome miRNAome epithelial cells 1‐ 3‐month‐old male female mice, predicted possible transcription factors target genes four most significantly differentially expressed miRNAs (DEMs) (miR‐183‐5p,...
This letter introduces an innovative Biological Physical Unclonable Function (Bio-PUFs) architecture designed to generate secure secrets. The core of this utilizes a bionic tunable ion gel-gated synaptic transistor array in flexible high-density superficial non-invasive electronic components. exhibits distinct responses excitation signals varying frequencies, and by feeding these into the array, we can compare resulting outputs with predefined threshold voltage. outcome comparison is...
Orf virus (ORFV) is the causative agent of contagious ecthyma, which a zoonotic disease that affects sheep, goats, wild small ruminants and humans. Shandong Province in East China one main producing areas for sheep goats. Here, we conducted epidemiological surveys different this Province, isolated three orf strains, SDLC, SDTA SDJN, from goat flocks then analyzed genetic evolution these strains. The ORFV011, ORFV059, ORFV109, ORFV110 ORFV127 genes strains were amplified, sequenced analyzed....
Thymic degeneration and regeneration are regulated by estrogen androgen. Recent studies have found that long non-coding RNAs (lncRNAs) microRNAs (miRNAs) involved in organ development. In this study, RNA sequencing (RNA-seq) results showed ovariectomy significantly affected 333 lncRNAs, 51 miRNAs, 144 mRNAs levels (p < 0.05 |log2fold change| > 1), orchiectomy 165 208 mRNA the thymus. Gene Ontology (GO) Kyoto Encyclopedia of Genes Genomes (KEGG) analysis differentially expressed genes (DEGs)...
Thymus is the primary organ for T cell differentiation and maturation. Many studies have demonstrated that estrogen plays a crucial role in thymic epithelial (TEC) proliferation during involution. LncRNAs are involved various biological processes; however, estrogen-mediated lncRNA expression TECs has not been yet reported. To address this question, mouse medullary line 1 (MTEC1) was treated with 17β-estradiol (E2). By using CCK8 assay flow cytometry, we found E2 able to inhibit viability of...
Abstract Thymic epithelial cells (TECs) are essential regulators of T-cell development and selection. miRNAs play critical roles in regulating TEC proliferation during the process thymic aging. Our previous studies revealed that miR-199b-5p was upregulated TECs from 1- to 3-month-old mice. But its function potential mechanism not clear. We hypothesized may an important role age-related thymus involution via targeting some genes. To confirm it, murine cell line 1 (MTEC1) were used. results...
The NOD-like receptor protein 3 (NLRP3) inflammasome comprised of NLRP3, ASC and caspase-1 plays an important role in the inflammatory innate immune response. However, little is known about expression pattern histological distribution these genes goat. Here, we first cloned fulllength cDNAs Hainan black goat produced their polyclonal antibodies. Tissue-specific were analysed. Phylogenetic analysis revealed that three had high homology with Bos taurus low avian or fish genes. After...
MicroRNAs (miRNAs) control the proliferation of thymic epithelial cells (TECs) for involution. Previous studies have shown that expression levels miR-152-3p were significantly increased in thymus and TECs during involution mouse thymus. However, possible function potential molecular mechanism remains unclear. This study identified overexpression can inhibit, while inhibition promote, murine medullary cell line 1 (MTEC1) cells. Moreover, was quantitatively analyzed to negatively regulate...