A5013823117- Glaucoma and retinal disorders
- Neurological Disorders and Treatments
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Atherosclerosis and Cardiovascular Diseases
- Ocular Diseases and Behçet’s Syndrome
- Cerebral Venous Sinus Thrombosis
- Connexins and lens biology
- Ocular Infections and Treatments
- Ocular and Laser Science Research
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Dermatologic Treatments and Research
- Syphilis Diagnosis and Treatment
- Flavonoids in Medical Research
- S100 Proteins and Annexins
- Advanced Glycation End Products research
- Optical Systems and Laser Technology
- Protease and Inhibitor Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Intersectoral Research and Technology Complex Eye Microsurgery
2016-2025
Ministry of Health of the Russian Federation
2016-2025
Siberian Branch of the Russian Academy of Sciences
2021
Institute of Clinical and Experimental Lymphology
2021
Russian Academy of Sciences
2021
Institute of Cytology and Genetics
2021
IFC Research (United Kingdom)
2021
THz radiation is increasingly used for diagnostics in medicine. As technology utilizing continues to develop rapidly, it becoming important consider its biological effects and establish safe exposure standards parameters. The paper presents data on the clinical status functional properties of anterior posterior structures eyes rabbits after irradiation at frequency 2.3 THz. Terahertz was generated Novosibirsk Free Electron Laser (NovoFEL) "Siberian Synchrotron Radiation Centre" (Budker...
Modern research shows that innate immunity plays an important role in the pathogenesis of primary open-angle glaucoma (POAG). An increase content toll-like receptors (TLR) glaucomatous retina human eye was revealed. TLRs can modulate immune response glaucoma; provide early recognition damaging agents, activation signaling pathways and effector mechanisms nonspecific defense system aimed at restoring homeostasis. The TLR-encoding genes’ polymorphism alters amino acid structure receptors,...
Exosomes represent a sort of extracellular vesicles, which transfer molecular signals in organism and possess markers producing cells. Our study was aimed at search exosomes the tears healthy humans, confirmation their nature examination exosome morphological molecular-biological characteristics. The (110-340 ml) were collected from 24 donors (aged 46-60 years); individual probes centrifuged 20000 g for 15 min to pellet cell debris. supernatants examined electron microscope using negative...
ObjectivesTo investigate the possible role of cystatin C in eye biological fluids locally and serum lactoferrin revealing anti-tumor activity tumor development.BackgroundThe increased number tumors was registered recently not only countries with high insolation, but also northern including Russia (11 cases per million population). Search for new markers is important diagnosis prognosis tumors. Cystatin C, an endogenous inhibitor cysteine proteases, plays protective several Lactoferrin shown...
Fibroblasts isolated and expanded from ReLEx SMILE lenticules can be a source of human keratocytes. Since corneal keratocytes are quiescent cells, it is difficult to expand them in vitro suitable numbers for clinical experimental use. In the present study, this problem was solved by isolating growing fibroblasts (CFs) with high proliferative potential their reversion selective serum-free medium. reversed into (rCFs) had dendritic morphology ultrastructural signs activation protein synthesis...
The paper provides an overview of the results multiyear joint researches team collaborators Institute Laser Physics SB RAS together with NF IRTC "Eye Microsurgery" for period from 1988 to present, in which were first proposed and experimentally realized laser medical technologies correction refractive errors known today as LASIK, treatment ophthalmic herpes open-angle glaucoma. It is carry out operations use UV excimer KrCl a wavelength 222 nm. same emission most suitable herpes, because it...
AIM: To study polymorphisms in promotor regions of tumor necrosis factor (TNF)-α TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), and TNF-238A/G (rs361525) patients with age-related macular degeneration (AMD) associations complex TNF-α genotypes AMD. METHODS: One hundred two (82 women, 20 men; mean age 64.2±1.2y) AMD 100 healthy age- sex-matched controls 18 60±1.4y) were included the study. All subjects Caucasian, all their parents inhabitants Russia. Genomic DNA was obtained from...
Purpose. To study the content of cytokines and growth factors in intraocular fluid patients with developed stage primary open-angle glaucoma (POAG). Materials methods. 56 a verified diagnosis glaucomawere examined. The control group consisted 30 uncomplicated cataract. A concentration 17 cytokinesand 3 isoforms transforming factor (TGF) β was determined using Bio-Plex Pro™ Human Cytokine 17-plex Assay TGFβ 3-plex kit by flow-through fluorometry on 200, Bio-Rad double beam laser analyzer,...
Abstract Background The aim of the study was to determine concentration endogenous cystatin C and SN, as potential tumor biomarkers, in serum biological fluids eye both healthy controls patients with uveal melanoma. Patients methods cystatins determined intraocular fluid (IOF), tear fluid, melanoma compared baseline measurements IOF, tears, serum, cerebral spinal saliva urine controls. Results all matrices obtained from significantly exceeded SN independent gender. Cystatin concentrations...
To establish possible association between age-related macular degeneration (AMD) and cytokine genotype polymorphisms; for that promoter regions of a number genes were studied, namely, TNF-A863C, TNF-A308G, TNF-A238G, IL1β-C-31T, IL4-C590T, IL6-C174G, IL10A-1082G.A total 102 AMD 100 non-AMD participants in the same age range examined at Novosibirsk branch Academician S.N. Fyodorov IRTC «Eye Microsurgery». In all cases restriction fragment length polymorphism analysis was performed.The...
Diabetic macular edema (DME) is a common complication associated with the loss of visual acuity in diabetic patients. Intravitreal injections vascular endothelium growth factor (VEGF) inhibitors (anti-VEGF therapy) have been proposed recently as new treatment option for patients DME. In this review we summarized results randomized clinical trials VEGF DME The indicate that all studied (ranibizumab, bevacizumab, pegaptanib and aflibersept) reduce retinal thickness improve when are used...
Epidemiological investigation of pseudoexfoliative syndrome (PEX) as a glaucoma predictor is necessary for antiglaucoma treatment planning.To study the prevalence PEX and (PXFG) among healthy people, naïve patients, patients under observation well to evaluate hypotensive efficacy bimatoprost/timolol fixed combination (FCBT) over 4 months in PXFG.Epidemiological analysis, ophthalmological examination, statistical analysis.The Novosibirsk region citizens 19.9%. In ophthalmologically...
The review presents information of contemporary scientific literature regarding the role various classes cytokines and growth factors in pathogenesis proliferative diabetic retinopathy (PDR). Information PDR biologically active molecules, involved inflammatory angio-proliferative processes, is a basis for selection potential molecular targets development new bio-engineering drugs.
We report the results of an experimental study effect short-pulse laser UV radiation on eye scleral tissue. As samples, we used isolated flaps tissue from patients with open-angle glaucoma second and third stages. The impact was implemented using excimer XeCl a wavelength 308 nm tunable within 210 to 355 nm. Depending problem be solved, energy density surface irradiated varied fraction mJ cm–2 15 J cm–2. For first time studied optical properties intraocular fluid in blue spectral range....
Purpose. To study transforming growth factors – beta 1,2,3 (TGF-β1, TGF-β2, TGF-β3) in intraocular aqueous humor (AH) of patients with the advanced stage primary open angle glaucoma (POAG). Material and methods. The included an examination 56 POAG which comprised main group. diagnosis was confirmed based on ophthalmological examination. control group consisted 30 uncomplicated cataract. TGF-β isoforms concentrations were detected by flow fluorimetry using Bio-Plex Pro™ 3-plex Assay...
Cell-based therapies using corneal stromal stem cells (CSSC), keratocytes, or a combination of both suppress scarring. The number quiescent keratocytes in the cornea is small; it difficult to expand them vitro quantities suitable for transplantation. This study examined therapeutic effect fibroblasts reversed into (rCF) mouse model mechanical injury. rCF was studied vivo (slit lamp, optical coherence tomography) and ex (transmission electron microscopy immunofluorescence staining). Injection...