A5052441582- Radiation Therapy and Dosimetry
- Radiation Effects and Dosimetry
- Carcinogens and Genotoxicity Assessment
- Effects of Radiation Exposure
- Digital Innovation in Industries
- Nuclear Physics and Applications
- Corporate Governance and Management
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Geophysics and Gravity Measurements
- Microtubule and mitosis dynamics
- Glioma Diagnosis and Treatment
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Spaceflight effects on biology
- Geomagnetism and Paleomagnetism Studies
- Radioactive contamination and transfer
- Epigenetics and DNA Methylation
- Distributed and Parallel Computing Systems
- Scientific Research and Discoveries
- Radioactivity and Radon Measurements
- Statistical and numerical algorithms
Federal Office for Radiation Protection
2020-2025
Medizinische Hochschule Hannover
2019
Université Paris Cité
2016
University of KwaZulu-Natal
2016
Centre National de la Recherche Scientifique
2016
Tools for radiation exposure reconstruction are required to support the medical management of victims in radiological or nuclear incidents. Different biological and physical dosimetry assays can be used various scenarios estimate dose ionizing a person has absorbed. Regular validation techniques through inter-laboratory comparisons (ILC) is essential guarantee high quality results. In current RENEB comparison, performance established cytogenetic [dicentric chromosome assay (DCA),...
Abstract In previous RENEB interlaboratory comparisons based on the manual scoring of dicentric chromosomes, a tendency for systematic overestimation doses > 2.5 Gy was found. However, these exercises included only very few in high dose range, and they were heterogeneous terms radiation quality evaluation mode, comparable to limited extent. Here, this presumed deviation explored by investigating three Gy. Blood samples irradiated (2.56, 3.41 4.54 Gy) using 60 Co source sent 14 member...
Abstract Astronauts travelling in space will be exposed to mixed beams of particle radiation and photons. Exposure limits that correspond defined cancer risk are calculated by multiplying absorbed doses a radiation-type specific quality factor reflects the biological effectiveness without considering possible interaction with We have shown previously alpha X-rays may interact resulting synergistic DNA damage responses human peripheral blood lymphocytes but level intra-individual variability...
After large-scale radiation accidents where many individuals are suspected to be exposed ionizing radiation, biological and physical retrospective dosimetry assays important tools aid clinical decision making by categorizing into unexposed/minimally, moderately or highly groups. Quality-controlled inter-laboratory comparisons of simulated accident scenarios regularly performed in the frame European legal association RENEB (Running Network Biological Physical Dosimetry) optimize international...
Biological dosimetry is an internationally recognized method for quantifying and estimating radiation dose following suspected or verified excessive exposure to ionising radiation. In severe accidents where a large number of people are potentially affected, it possible distinguish irradiated from non-irradiated in order initiate appropriate medical care if necessary. addition incidents caused by technical failure, environmental disasters, military actions, criminal abuse, there also which...
Ataxia-telangiectasia (AT) is a rare inherited recessive disorder which caused by mutated (ATM) gene. Hallmarks include chromosomal instability, cancer predisposition and increased sensitivity to ionizing radiation. The ATM protein plays an important role in signaling of DNA double-strand breaks (DSB), thereby phosphorylating the histone H2A.X. Non-functional leads defects damage response, unresolved DSBs genomic instability. aim this study was evaluate aberrations γH2A.X foci as potential...
In the case of a radiological or nuclear event, biological dosimetry can be an important tool to support clinical decision-making. During individuals might exposed mixed field neutrons and photons. The composition neutron energy spectrum influence degree damage chromosomes. transatlantic BALANCE project, exposure similar Hiroshima-like device at distance 1.5 km from epicenter was simulated, based on dicentric chromosomes performed evaluate participants ability discover unknown doses test...
In case of population exposure by ionizing radiation, a fast and reliable dose assessment exposed non-exposed individuals is crucial important. initial triage, physicians have to take decisions whom treat with adequate medical care. addition, worries about significant can be taken away from hundreds thousands non- or low individuals. Studies shown that the γH2A.X radiation-induced foci assay promising test for triage decisions. However, in large-scale scenario most biodosimetry laboratories...
X-ray cabinets are replacing 137 Cs/60 Co sources in radiation biology research due to advantages size, handling, and protection. However, because of their different physical properties, more susceptible experimental influences than conventional sources. The aim this study was examine the variations related setups typically used investigate biological effects with cabinets.A combined approach dose measurements by thermoluminescence dosimetry detection quantification γH2AX 53BP1 foci analyze...
Purpose In cases of radiological or nuclear events, biological dosimetry enables decisions whether an individual was exposed to ionizing radiation and the estimation dose. Several statistical methods are used assess uncertainties. The stringency applied method has impact on lowest dose that can be detected. To obtain reliable comparable results, it is crucial harmonize methods.
Systematic bio- and databanks are key prerequisites for modern radiation research to investigate response mechanisms in the context of genetic, environmental lifestyle-associated factors. This report presents current status German Uranium Miners’ Biobank. In 2008, databank was established at Federal Office Radiation Protection, sampling biological materials from former uranium miners with without lung cancer initiated. For this purpose, various specimens, such as DNA RNA, were isolated blood...
In biological dosimetry, dose-response curves are essential for reliable retrospective dose estimation of individual exposure in case a radiation accident. Therefore, blood samples irradiated vitro and evaluated based on the applied assay. Accurate physical dosimetry irradiation performance is critical part experimental procedure influenced by setup, especially when X-ray cabinets used. The aim this study was to investigate variations pitfalls associated with setups used establish...
We present an exact expression for the $1/f$ contribution to noise of CMB temperature and polarization maps a survey in which scan pattern is isotropic. The result applies likewise surveys with without rotating half-wave plate. A representative range parameters explored implications design optimization future are discussed. These results most directly applicable space-based surveys, afford considerable freedom choice on celestial sphere. discuss applicability methods developed here analyzing...
Zusammenfassung Bei einer unklaren, übermäßigen Exposition durch ionisierende Strahlung am Menschen bietet die biologische Dosimetrie Möglichkeit, diese retrospektiv nachzuweisen und gegebenenfalls zu quantifizieren. Besonders hilfreich ist dies in Fällen, denen keine physikalische Dosisrekonstruktion möglich oder widersprüchliche Ergebnisse vorliegen. Grundlage für sind zelluläre Reaktionen, DNA-Schäden Fehlreparaturen nach gegenüber ionisierender Strahlung. Die der biologischen...