A5033567152- Spine and Intervertebral Disc Pathology
- Spinal Cord Injury Research
- Nerve injury and regeneration
- Pregnancy-related medical research
- Thyroid Disorders and Treatments
- Occupational exposure and asthma
- Tendon Structure and Treatment
- Protein Hydrolysis and Bioactive Peptides
- Neurogenesis and neuroplasticity mechanisms
- Musculoskeletal pain and rehabilitation
- Nutrition, Health and Food Behavior
- Pelvic floor disorders treatments
- Food Quality and Safety Studies
- Shoulder Injury and Treatment
- Cervical and Thoracic Myelopathy
- Indoor Air Quality and Microbial Exposure
- Adipose Tissue and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Health and Wellbeing Research
- Spinal Hematomas and Complications
- Thyroid and Parathyroid Surgery
- Diet, Metabolism, and Disease
- Pain Mechanisms and Treatments
Chungnam National University Hospital
2014-2023
Yonsei University
2012-2021
Chungnam National University
2011-2021
Gyeongsang National University
2019
Ansan University
2016-2018
Korea University
2014-2018
Korea Research Institute of Bioscience and Biotechnology
2014-2017
Ajou University
2007-2014
Genetic Resources Center
2014
Bioprocess Control (Sweden)
2013
Although the central branches of dorsal root ganglion (DRG) sensory neurons do not spontaneously regenerate, a conditioning peripheral injury can promote their regeneration. A potential role macrophages in axonal regeneration was proposed, but it has been critically addressed whether play an essential model. After sciatic nerve (SNI) rats, number DRGs gradually increased by day 7. The increase persisted up to 28 d and accompanied upregulation inflammatory mediators, including oncomodulin....
Tissue engineering has been used for bladder augmentations with small intestinal submucosa (SIS). Although favorable short-term outcomes have reported, long-term followup poor. We investigate whether tissue stem cells improves the morphological and genetic composition.A total of 33 Lewis rats (Harlan Laboratories, Indianapolis, Indiana) were to 4-layer SIS in certain groups, including control group (sham operation), partial cystectomy oversewn defect (OG), augmentation unseeded (USG) cell...
ABSTRACT The purpose of this study was to investigate the anti‐inflammatory effect platelet‐rich plasma (PRP) with collagen matrix on human nucleus pulposus (NP) cell in response pro‐inflammatory cytokines such as tumor necrosis factor‐alpha (TNF‐α) and interleukin‐1 (IL‐1). NP cells from disks were cultured a monolayer maintained prior addition recombinant IL‐1 TNF‐α. After applying TNF‐α, PRP prepared by using commercially available platelet concentration system added. investigated...
Study Design: In vitro experiment using degenerated human ligamentum flavum (LF) and various inflammatory cytokines. Objectives: To examine the effect of cytokines on LF cells to identify their roles in pathogenesis hypertrophy ossification. Summary Background Data: Spinal stenosis is caused, part, by ossification LF, which are induced degenerative processes (ie, increased collagen synthesis chondroid metaplasia) ligament fibroblasts. Degenerated intervertebral disk spontaneously produces...
Neural stem cells (NSCs) possess therapeutic potentials to reverse complex pathological processes following spinal cord injury (SCI), but many obstacles remain that could not be fully overcome by NSC transplantation alone. Combining complementary strategies might required advance NSC-based treatments the clinical stage. The present study was undertaken examine whether combination of NSCs, polymer scaffolds, neurotrophin-3 (NT3), and chondroitinase, which cleaves chondroitin sulfate...
The dopamine precursor l -3,4-dihydroxyphenylalanine ( -DOPA) is widely used as a therapeutic choice for the treatment of patients with Parkinson's disease. However, long-term use -DOPA leads to development debilitating involuntary movements, called -DOPA-induced dyskinesia (LID). cAMP/protein kinase A (PKA) signaling in striatum known play role LID. from among nine adenylyl cyclases (ACs) present striatum, AC that mediates LID remains unknown. To address this issue, we prepared an animal...
Abstract Traumatic spinal cord injury (SCI) triggers inflammatory reactions in which various types of cells and cytokines are involved. Several proinflammatory up‐regulated after SCI play crucial roles determining the extent secondary tissue damage. However, relatively little is known about antiinflammatory their trauma. Recent studies have shown that an cytokine, interleukin‐4 (IL‐4), expressed exerts modulatory effects CNS inflammation. We found present study IL‐4 was highly at 24 hr...
Nonsteroidal anti-inflammatory drugs are a mainstay for medical treatment of chronic lower back pain (CLBP). Increased dose intervals medication have been associated with increased patient adherence to prescriptions. The purpose this clinical trial was compare the efficacy and safety once daily aceclofenac controlled release (CR) twice CLBP management.A prospective, randomized, single center, open-label performed CR (200 mg daily) (100 daily). Fifty patients in each group were enrolled...
Background Postoperative thyroid stimulating hormone (TSH) suppression therapy is recommended for patients with intermediate- and high-risk differentiated cancer to prevent the recurrence of cancer. With recent increase in small cases, extent resection during surgery has generally decreased. Therefore, questions have been raised about efficacy long-term side effects TSH who undergone a lobectomy. Methods This multicenter, prospective, randomized, controlled clinical trial which 2,986...
Humulus japonicus (HJ), popularly known as Japanese hops, is a traditional herbal medicine widely used for the treatment of pulmonary disease, skin and hypertension in Korea. HJ exerts scavenging effects against reactive oxygen species (ROS), such superoxide radical, hydroxyl hydrogen peroxide. Moreover, dysfunction damage mitochondria elicited by ROS are critical importance pathogenesis Parkinson's disease (PD). The present study aimed to examine neuroprotective potential extracts using...
Dupuytren's disease is a fibroproliferative connective tissue disorder characterized by contracture of the palmer fascia hand. Relaxin (RLN) multifunctional factor which contributes to remodeling pelvic ligament inhibiting fibrosis and inflammatory activities. The aim this study was investigate effect RLN gene on inhibition in myofibroblastic cells. Myofibroblast cells with adenovirus LacZ (Ad-LacZ) as marker or relaxin (Ad-RLN) therapeutic showed transgene expressions beta-galactosidase...
Study Design: In vitro experiment using degenerated human ligamentum flavum (LF) and herniated intervertebral disk (IVD). Objectives: To investigate the role effect of IVDs on LF hypertrophy ossification. Summary Background Data: Spinal stenosis is caused, in part, by ossification LF, which are induced aging degenerative process. It well known that spontaneously produce inflammatory cytokines. Therefore, we hypothesized IVD may affect adjacent through secreted Methods: lumbar tissues were...
Four types of roe protein isolates (RPIs) were prepared through the alkaline solubilization and acid precipitation (ASAP) process, their functional properties in vitro bioactivities evaluated. Higher buffer capacity pH-shift range 8-12 was found RPI-1 (pH 11/4.5), required average 94.5 mM NaOH than that other RPIs to change pH by 1 unit. All samples 1% dispersion (w/v) showed lowest buffering near initial pH. The water-holding capacities (WHC) casein as controls without 3.7-4.0 g/g protein,...
Ghrelin, an endogenous ligand of the GH (growth hormone) secretagogue receptor, influences many metabolic processes including secretion, food intake, energy balance, insulin secretion and adipogenesis. Although ghrelin exhibits a variety biological functions, mechanism by which expression is regulated unknown. Ghrelin expressed in gastrointestinal tract, predominantly stomach, as KLF4 (Krüppel-like factor 4). Therefore we investigated whether associated with KLF4, found that tissue...
Context Thyroid-stimulating hormone (TSH) suppression is recommended to reduce tumor recurrence following surgery for differentiated thyroid cancer (DTC). However, prolonged subclinical hyperthyroidism caused by levothyroxine treatment has deleterious effects on various organs. Objective To evaluate the relationships of TSH concentration with muscle mass, strength, and physical performance related sarcopenia in patients DTC undergoing surgery. Methods We studied 134 >60 years who were...
Abstract Objective: To assess the impact of intraoperative intravenous dexamethasone on reduction postoperative morbidity in children undergoing adenotonsillectomy. Methods: A double blind randomized controlled trial conducted among adenotonsillectomy at a tertiary hospital Korea from November 2018 to June 2019. Children were randomly assigned receive (0.5 mg/kg, maximum dose 24 mg) or placebo intravenously after induction anesthesia. The primary endpoint was pain and nausea vomiting (PONV);...
Type 2 deiodinase (DIO2)-mediated thyroid hormone synthesis stimulates osteoblast activity and increases the expression of differentiation markers, but there are no large cohort studies to identify role DIO2 polymorphism in bone mineral density humans.To investigate hypothesis that individuals with gene susceptible osteoporosis, we assessed 7,524 Koreans drawn from large-scale Ansan-Anseong Korean Genome Epidemiology Study. All participants underwent genotyping Thr92Ala (rs225014).A total...