Herculano da Silva Martinho

ORCID: 0000-0002-7690-014X
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About
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Research Areas
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Spectroscopy and Chemometric Analyses
  • Bee Products Chemical Analysis
  • Supramolecular Self-Assembly in Materials
  • Advancements in Transdermal Drug Delivery
  • Photoacoustic and Ultrasonic Imaging
  • Laser Applications in Dentistry and Medicine
  • Lipid Membrane Structure and Behavior
  • Biosensors and Analytical Detection
  • SARS-CoV-2 and COVID-19 Research
  • Molecular Biology Techniques and Applications
  • Oral microbiology and periodontitis research
  • Collagen: Extraction and Characterization
  • Advanced biosensing and bioanalysis techniques
  • Optical Imaging and Spectroscopy Techniques
  • Metabolomics and Mass Spectrometry Studies
  • Salivary Gland Disorders and Functions
  • SARS-CoV-2 detection and testing
  • Shoulder Injury and Treatment
  • Essential Oils and Antimicrobial Activity
  • Molecular spectroscopy and chirality
  • Electrochemical sensors and biosensors
  • Nanopore and Nanochannel Transport Studies
  • Microbial infections and disease research
  • Advanced Condensed Matter Physics

Universidade Federal do ABC
2015-2025

Centro Regional de Derechos Humanos y Justicia de Género, Corporación Humanas
2015-2025

Natura (Brazil)
2024

Centro Universitário Fundação Santo André
2010-2021

Universidade do Vale do Paraíba
2006-2008

Universidade Estadual de Campinas (UNICAMP)
2004

A Raman spectroscopic study of the high-frequency optical phonons in single crystals multiferroic system $R{\mathrm{Mn}}_{2}{\mathrm{O}}_{5}$ ($R=\mathrm{Bi}$, Eu, Dy) was performed. All studied materials show anomalous phonon shifts, below a new characteristic temperature for these materials, ${T}^{*}\ensuremath{\sim}60--65\phantom{\rule{0.3em}{0ex}}\mathrm{K}$. The sign and magnitude such shifts appear to be correlated with ionic radius $R$, envolving from softenings $R=\mathrm{Bi}$...

10.1103/physrevb.73.104411 article EN Physical Review B 2006-03-10

Oral squamous cell carcinoma (OSCC) represents 90% of oral malignant neoplasms. The search for specific biomarkers OSCC is a very active field research contributing to establishing early diagnostic methods and unraveling underlying pathogenic mechanisms. In this work we investigated the salivary metabolites metabolic pathways aiming find possible biomarkers. Salivary samples from 27 patients 41 control individuals were compared through gas chromatography coupled mass spectrometer (GC-MS)...

10.3390/metabo11100650 article EN cc-by Metabolites 2021-09-23

Peri-implantitis is characterized as a pathological change in the tissues around dental implants. Fourier-transform infrared spectroscopy (FTIR) provides molecular information from optical phenomena observed by vibration of molecules, which used biological studies to characterize changes and serves form diagnosis. this case-control study evaluated peri-implant disease using FTIR with attenuated total reflectance fingerprint region. 38 saliva samples were evaluated, 17 control group 21...

10.1021/acs.jproteome.4c00707 article EN cc-by Journal of Proteome Research 2025-01-10

10.1038/s44161-025-00610-8 article EN Nature Cardiovascular Research 2025-02-06

Electronic cigarettes (e-cigs), initially introduced as smoking cessation aids, have given rise to a new wave of nicotine dependence. A critical question that has emerged is the potential adverse effects e-cig use on oral health, particularly how vapor emitted from these devices may alter salivary composition users. Here, we investigate users and analyze e-liquids (flavorings) using Fourier-transform infrared (FTIR) spectroscopy. Saliva samples were categorized into two groups: e-cigarette...

10.1021/acsomega.4c08648 article EN cc-by ACS Omega 2025-03-14

Biochemical changes in the cervix during labor are not well understood. This gap knowledge is significant, as understanding precise biochemical processes can provide critical insights into mechanisms of and potentially inform better clinical practices for monitoring managing pregnancy childbirth. Fourier-transform infrared (FT-IR) spectroscopy a non-invasive optical technique, it has potential sensibility to detect components. technology operates by meansuring vibrational energy molecular...

10.1186/s12884-024-06941-x article EN cc-by-nc-nd BMC Pregnancy and Childbirth 2025-03-27

Caffeine is a highly beneficial compound for human health, known its anticancer, anti-inflammatory, and antioxidant properties, particularly in protecting the skin from UVB radiation damage. Although caffeine shows excellent...

10.1039/d4cp04377d article EN Physical Chemistry Chemical Physics 2025-01-01

In this work we employ the Fourier Transform Raman Spectroscopy to study normal and tumoral human breast tissues, including several subtypes of cancers. We analyzed 194 spectra from tissues that were separated into 9 groups according their corresponding histopathological diagnosis. The assignment relevant bands enabled us connect kinds (normal pathological) biochemical moieties alterations distinguish among 7 groups: breast, fibrocystic condition, duct carcinoma-in-situ, carcinoma-in-situ...

10.1117/1.2363362 article EN Journal of Biomedical Optics 2006-01-01

The contamination of the Raman scattering signal with luminescence is a well-known problem when dealing biological media excited by visible light. viability shifted-excitation difference spectroscopy (SERDS) technique for suppression on spectra samples was studied in this work. A tunable Lithrow-configuration diode laser (λ = 785 and 830 nm) coupled (directly or optical fiber) to dispersive spectrometer employed study two sets human tissues (tooth skin) order determine set experimental...

10.1364/boe.1.000617 article EN Biomedical Optics Express 2010-08-19

Abstract Renal injury caused by renal ischemia and reperfusion strongly influences heart morphology, electrophysiology, redox unbalance. The so-called cardiorenal syndrome is an important class of dysfunction since kidneys are responsible for hemodynamic stability organ perfusion through a complex network. In the present work we investigate vibrational spectral features probed Fourier-Transform Raman (FT-Raman) spectroscopy due to physiological alterations induced ischemic aiming detect...

10.1038/s41598-021-93762-z article EN cc-by Scientific Reports 2021-07-22

Low-level laser therapy (LLLT) is an emerging therapeutic approach for several clinical conditions. The effects induced by LLLT presumably scale from photobiostimulation/photobioinhibition at the cellular level to molecular level. detailed mechanism underlying this effect remains unknown. This study quantifies some relevant aspects of related and variations. Malignant breast cells (MCF-7) were exposed spatially filtered light a He-Ne (633 nm) with fluences 5, 28.8, 1000 mJ/cm2. cell...

10.1117/1.jbo.17.10.101516 article EN Journal of Biomedical Optics 2012-08-03

It has been reported that patients diagnosed with COVID-19 become critically ill primarily around the time of activation adaptive immune response. However role antibodies in worsening disease is not obvious. Higher titers anti-spike immunoglobulin IgG1 associated low fucosylation antibody Fc tail have to excessive inflammatory In contrast it also NP-, S-, RBD- specific IgA, IgG, and IgM are SARS-CoV-2 viral load, indicating there no obvious correlation between response antigen detection....

10.1038/s41598-022-08156-6 article EN cc-by Scientific Reports 2022-03-11

Background The SARS-CoV-2 infections are still imposing a great public health challenge despite the recent developments in vaccines and therapy. Searching for diagnostic prognostic methods that fast, low-cost accurate essential disease control patient recovery. MALDI-TOF mass spectrometry technique is rapid, low cost when compared to other MS methods, thus its use already reported literature various applications, including microorganism identification, diagnosis prognosis of diseases.Methods...

10.1080/20002297.2022.2043651 article EN cc-by Journal of Oral Microbiology 2022-02-27

Two-dimensional Ruddlesden-Popper (RP) perovskites are emerging materials offering great synthetic versatility and remarkable features due to the tunability of their crystal structure. We present a novel strategy provide magnetism in 2D RP perovskite using histidine molecules as spacer, which could induce charge rebalancing at interface inorganic layer. observe that amide imidazole groups close Pb ions. The interaction with indicates this functional group, possibly assisted by carboxyl...

10.1021/acs.jpclett.1c04216 article EN The Journal of Physical Chemistry Letters 2022-02-04

Abstract The synthesis, structural characterisation and magnetic properties of a new chloro‐bridged linear chain imine‐copper(II) compound are reported. results indicate that uniform chains formed by stacking parallel pyramidal units from the copper centre coordinated to imine ligands bridged chloride ions, with uncoordinated perchlorate ions located between layers balance charge. Magnetic measurements carried out on powder sample at temperatures 1.8 290 K field 500 Oe, indicated an...

10.1002/ejic.200801218 article EN European Journal of Inorganic Chemistry 2009-04-14

The objectives of this study were to evaluate the effect low-level laser irradiation (LLLI) on bovine oocyte and granulosa cells metabolism during in vitro maturation (IVM) further embryo development. Cumulus-oocytes complexes (COCs) subjected (experimental group) or not (control with LLLI a 633-nm wavelength 1 J/cm 2 fluency. COCs evaluated after 30 min, 8, 16, 24 h IVM. Cumulus for cell cycle status, mitochondrial activity, viability (flow cytometry). Oocytes assessed meiotic progression...

10.1117/1.jbo.19.3.035006 article EN Journal of Biomedical Optics 2014-03-21

Abstract Genomic surveillance has been applied since the beginning of COVID‐19 pandemic to track spread virus, leading characterization multiple SARS‐CoV‐2 variants, including variants concern (VOC). Although sequencing is standard method, a rapid molecular test for screening and VOC considered detection. Furthermore, using alternative saliva as specimen collection facilitates implementation less invasive, self‐collected sample. In this study, we combinatory strategy reverse transcription...

10.1002/jmv.27839 article EN Journal of Medical Virology 2022-05-07

The Fourier transform (FT)-Raman spectroscopy technique is used to assess the biochemical alterations that occur in degenerative process of rotator cuff supraspinatus tendon. main observed glycine, proline, hydroxyproline, cysteine, cistine, phenylalanine, tyrosine, collagen I and III, nucleic acid, lipids, glycosaminoglycans, metalloproteinases bands. An increasing intensity for these bands found degenerated tendons, a finding well correlated with hyaline state cellular activity....

10.1117/1.2841017 article EN Journal of Biomedical Optics 2008-01-01

To qualify the FT-Raman spectral data of primary and metastatic cutaneous melanoma in order to obtain a differential diagnosis.Ten normal human skin samples without any clinical or histopathological alterations, ten fragments, nine lymph node metastasis were used; 105, 140 126 spectra obtained respectively. Each sample was divided into 2 3 fragments approximately mm³ positioned Raman spectrometer holder spectra; monochrome laser light Nd:YAG at 1064 nm used excite inelastic effect.To...

10.1590/s0102-86502010000500009 article EN cc-by Acta Cirúrgica Brasileira 2010-09-22

Vibrational spectroscopy has been widely employed to unravel the physical-chemical properties of biological systems. Due its high sensitivity monitoring real time "in situ" changes, Raman successfully employed, e.g., in biomedicine, metabolomics, and biomedical engineering. The interpretation spectra these cases is based on isolated macromolecules constituent vibrational assignment. this, probing anharmonic or mutual interactions among specific moieties/side chains a challenge. We present...

10.1364/boe.9.001728 article EN cc-by Biomedical Optics Express 2018-03-15
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