A5007596802- Neuroinflammation and Neurodegeneration Mechanisms
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ubiquitin and proteasome pathways
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Alzheimer's disease research and treatments
- Hereditary Neurological Disorders
- Tryptophan and brain disorders
- Immune cells in cancer
- Nerve injury and regeneration
- Hypothalamic control of reproductive hormones
- S100 Proteins and Annexins
- Neuropeptides and Animal Physiology
- Sexual Differentiation and Disorders
- Receptor Mechanisms and Signaling
- Galectins and Cancer Biology
- Autophagy in Disease and Therapy
- Reproductive Health and Technologies
- Adenosine and Purinergic Signaling
- Signaling Pathways in Disease
- Lipoproteins and Cardiovascular Health
- Nitric Oxide and Endothelin Effects
- Biochemical Acid Research Studies
- Pain Mechanisms and Treatments
Catholic Kwandong University
2018-2025
International St. Mary's Hospital
2018-2025
Incheon Catholic University
2019
Kyungpook National University
2014-2017
University of Pittsburgh
2009-2016
Yeungnam University
2013-2014
University of Rochester Medical Center
2004-2008
University of Rochester
2006
Lady of Mercy Medical Center
2004
Sungkyunkwan University
2000-2003
Orosomucoid (ORM) is an acute-phase protein that belongs to the immunocalin subfamily, a group of small-molecule-binding proteins with immunomodulatory functions. Little known about role ORM in CNS. The aim present study was investigate brain expression and its neuroinflammation. Expression Orm2, but not Orm1 or Orm3, highly induced mouse after systemic injection lipopolysaccharide (LPS). Plasma levels ORM2 were also significantly higher patients cognitive impairment than normal subjects....
Protein tyrosine phosphatase 1B (PTP1B) is a member of the non-transmembrane phosphotyrosine family. Recently, PTP1B has been proposed to be novel target anti-cancer and anti-diabetic drugs. However, role in central nervous system not clearly understood. Therefore, this study, we sought define PTP1B's brain inflammation.
Abstract Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer’s disease (AD) is associated reduced clearance. Older microglia have a ability to phagocytose amyloid, so phagocytosis by could be regulated prevent accumulation. Furthermore, considering the aging-related disruption cell cycle machinery old microglia, we hypothesize that regulating their rejuvenate them and enhance promote more efficient First, used gene ontology analysis from young mice identify...
Ascorbic acid has recently been reported to protect sperm DNA from the damage induced by exogenous oxidative stress in vitro. But, there is no report on seminal ascorbic and fragmentation infertile men. In this study, we asked whether correlates with levels. Sperm index (DFI) was analysed 75 men flow cytometry after acridine orange staining. We also measured levels of plasma total antioxidant capacity. Abnormal integrity (DFI >or= 30%) observed 12% patients normal semen parameters 52%...
Pyruvate dehydrogenase kinases (PDK1-4) are mitochondrial metabolic regulators that serve as decision makers via modulation of pyruvate (PDH) activity to convert either aerobically acetyl-CoA or anaerobically lactate. Metabolic dysregulation and inflammatory processes two sides the same coin in several pathophysiological conditions. The lactic acid surge associated with shift has been implicated diverse painful states. In this study, we investigated role PDK-PDH-lactic axis pathogenesis...
Abstract Hypothalamic inflammation plays an important role in disrupting feeding behavior and energy homeostasis as well the pathogenesis of obesity diabetes. Here, we show that pyruvate dehydrogenase kinase (PDK)-2 a hypothalamic its sequelae mouse models Cell type-specific genetic ablation pharmacological inhibition PDK2 astrocytes suggest are involved diabetic phenotype. We also PDK2-lactic acid axis regulatory observed metabolic imbalance primary astrocyte organotypic cultures, through...
Abstract Knee osteoarthritis (OA) is characterized by knee cartilage degeneration and secondary bone hyperplasia, resulting in pain, stiffness, gait disturbance. The relationship between OA neurodegenerative diseases still unclear. This study used an Alzheimer’s disease (AD) mouse model to observe whether accelerates dementia progression analyzing brain histology neuroinflammation. was induced destabilizing the medial meniscus (DMM) control (WT) AD (5xFAD) mice before pathological symptoms....
Reactive oxygen species (ROS)-mediated intracellular signalling is well described in the vasculature, yet precise roles of ROS paracrine are not known. Studies implicate interstitial hydrogen peroxide (H2O2) vascular disease, and plasma H2O2 levels micromolar range detectable animal models humans with hypertension. Recently, was shown to cross biological membranes non-vascular cells via aquaporin (Aqp) water channels. Previous findings suggest that activates NADPH oxidase (Nox) enzymes...
Emerging evidence suggests that systemic inflammation may play a critical role in neurological disorders. Recent studies have shown the connection between inflammatory bowel diseases (IBD) and disorders, revealing bidirectional relationship through gut-brain axis. Immunotherapies, such as Treg cells infusion, been proposed for IBD. However, of adaptive immune IBD-induced neuroinflammation remains unclear. In this study, we established an animal model IBD mice with severe combined...
Dimethyl fumarate (DMF), which has been approved by the Food and Drug Administration for treatment of relapsing-remitting multiple sclerosis, is considered to exert anti-inflammatory antioxidant effects. Microglia maintain homeostasis in central nervous system play a key role neuroinflammation, while autophagy controls numerous fundamental biological processes, including pathogen removal, cytokine production, clearance toxic aggregates. However, DMF induction relationship this effect with...
Fluoxetine is a classic antidepressant drug, and its immunomodulatory effects have recently been reported in many disease models. In addition, it has strong antineuroinflammatory stroke neurodegenerative animal However, the effect of fluoxetine on microglia phagocytosis molecular mechanisms not yet studied. this study, we investigated whether regulatory microglial function. Microglia cell lines primary mouse were treated with fluoxetine, production inflammatory cytokines neurotrophic factors...
The PTH type 1 receptor (PTH1R) and PTHrP are expressed in vessels, where they contribute to regulating vascular smooth muscle cell (VSMC) function. Elevated levels VSMC often associated with hyperplasia. In contrast, exogenous PTHrP, acting through the PTH1R, inhibits proliferation. this study, we investigated regulation of PTH1R expression by endogenous effects on Blocking binding secreted fragments treatment either an antagonist or antibody against inhibition small interfering RNA...
Significance Our findings identify a previously unidentified role for scaffolding protein ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50; aka NHERF1) in the activation of NADPH oxidases (Nox), family professional reactive oxygen species (ROS) producing enzymes implicated numerous pathologies. We demonstrate that EBP50 is critical agonist-induced production ROS superoxide anion (O 2 •– ), and it directly associates with Nox organizing subunit p47 phox . deletion abolishes angiotensin...
To study phosphorylation of the endogenous type I thyrotropin-releasing hormone receptor in anterior pituitary, we generated phosphosite-specific polyclonal antibodies. The major site endogenously expressed pituitary GH3 cells was Thr365 tail; distal sites were more phosphorylated some heterologous models. β-Arrestin 2 reduced (TRH)-stimulated inositol phosphate production and accelerated internalization wild but not mutants where critical phosphosites mutated to Ala. Phosphorylation peaked...
Deletions of USP9Y have been observed among infertile males with defective spermatogenesis. Therefore, the gene has designated as a male infertility on Y chromosome. However, it remains to be determined how results from deletions this gene. In order initiate an investigation into cellular functions in germ cell development, present study we characterized enzymatic specificity USP9Y. Our show that both and Fam, mouse protein Usp9x, possess protease activity specific ubiquitin. These suggest...