A5016249120- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Particle Accelerators and Free-Electron Lasers
- Particle Detector Development and Performance
- Particle accelerators and beam dynamics
- Superconducting Materials and Applications
- Radiation Effects and Dosimetry
- Advanced Data Storage Technologies
- Gyrotron and Vacuum Electronics Research
- Neutrino Physics Research
- Graphite, nuclear technology, radiation studies
- Laser-Plasma Interactions and Diagnostics
- Atomic and Subatomic Physics Research
- Quantum Chromodynamics and Particle Interactions
- Physics and Engineering Research Articles
- Aerospace Engineering and Energy Systems
- Nuclear Physics and Applications
- Radiation Effects in Electronics
- Geophysical Methods and Applications
- Medical Imaging Techniques and Applications
- Refrigeration and Air Conditioning Technologies
- Non-Destructive Testing Techniques
- Wireless Sensor Networks for Data Analysis
- Aerospace Engineering and Applications
University of Oxford
2020-2025
European Organization for Nuclear Research
2020-2024
University of Victoria
2024
Brookhaven National Laboratory
2016
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due their highly penetrating nature and applicability as modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions VHEE need be optimised; one option is through the use of quadrupole magnets focus beam, reducing healthy tissue allowing targeted delivery at or dose-rates. This paper presents an in depth exploration focusing achievable current CLEAR (CERN Linear Accelerator...
Very high energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favourable dose distributions and accessibility of ultrahigh dose-rates (UHDR). Combining VHEE the normal tissue-sparing effect UHDR could improve patient outcomes. The standard dosimeters used conventional radiotherapy, including ionization chambers film, have limited application deficits in rate independence temporal resolution. Plastic scintillator...
Spatially-fractionated radiotherapy (SFRT) delivered with a very-high-energy electron (VHEE) beam and mini-GRID collimator was investigated to achieve synergistic normal tissue-sparing through spatial fractionation the FLASH effect.
Abstract Objective . Very high energy electrons (VHEE) in the range of 50–250 MeV are interest for treating deep-seated tumours with FLASH radiotherapy (RT). This approach offers favourable dose distributions and ability to deliver ultra-high rates (UHDR) efficiently. To make VHEE-based treatment clinically viable, a novel beam monitoring technology is explored as an alternative transmission ionisation monitor chambers, which have non-linear responses at UHDR. study introduces fibre optic...
Abstract Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an known as ‘FLASH’. This studied across several radiation modalities, including photons, protons and clinical energy electrons, however, very little data is available for the of FLASH with Very High Energy Electrons (VHEE). pBR322 plasmid DNA was used biological model measure damage in response Electron (VHEE) at conventional (0.08 Gy/s), intermediate (96 Gy/s) ultra-high rates (UHDR,...
Optical Beam-Loss Monitors (oBLMs) allow for cost-efficient and spatially continuous measurements of beam losses at accelerator facilities. A standard oBLM consists several tens metres optical fibre aligned parallel to a beamline, coupled photosensors either or both ends. Using the timing information from loss signals, positions can be reconstructed. This paper presents novel system recently deployed CERN Linear Electron Accelerator Research (CLEAR). Multiple methods extracting position...
Abstract Background: The FLASH effect holds significant potential in improving radiotherapy treatment outcomes. Very high energy electrons (VHEEs) with energies the range of 50-250 MeV can effectively target tumors deep body and be accelerated to achieve ultra-high dose rates (UHDR), making them a promising modality for delivering clinic. However, apart from suitable VHEE sources, clinical translation requires accurate dosimetry, which is challenging due limitation standard dosimeters under...
Abstract Very High Energy Electrons (VHEE) that can theoretically treat deep-seated tumours and be delivered at ultra-high dose rates (UHDR) could the solution to translate FLASH radiotherapy into clinic. Standard dosimeters have limited application in those extreme conditions, but dose-rate independent fast-response plastic scintillation detectors (PSDs) are a potential alternative overcome this. In this work, response of 4-channel PSD 200 MeV VHEE UHDR beam with doses pulse up 90 Gy 4.6 ×...
The FLASH effect holds significant potential in improving radiotherapy treatment outcomes. Very high energy electrons (VHEEs) can effectively target tumors deep the body and be accelerated to achieve ultra-high dose rates (UHDR), making them a promising modality for delivering clinic. However, apart from suitable VHEE sources, clinical translation requires accurate dosimetry, which is challenging due limitation of standard dosimeters under UHDR. Water-equivalent real-time plastic...
Abstract FLASH has emerged as a significant breakthrough for the future of radiation oncology, it reduces complications while preserving tumor killing efficacy. To define beam parameters clinical translation, Very High Energy Electrons (VHEE) delivered at CLEAR and able to reach deep seated tumors were used in conjunction with FLASH-validated Intermediate Electron (IIE) 160-225 keV X-ray beam, collectively deliver dose rates spanning from 1 Gy/min 10 11 Gy/s. High-throughput chemical assays...
Very high energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favourable dose distributions and accessibility of ultrahigh dose-rates (UHDR). Combining VHEE the normal tissue-sparing effect UHDR could improve patient outcomes. The standard dosimeters used conventional radiotherapy, including ionization chambers film, have limited application deficits in rate independence temporal resolution. Plastic scintillator...

To evaluate spatially fractionated radiation therapy (SFRT) for very-high-energy electrons (VHEEs) delivered with pencil beam scanning.
For future linear colliders, a nanometer-scale beam size at the interaction point (IP) is one of most challenging technical aspects. To explore feasibility final focus system with high chromaticity level, comparable to that Compact Linear Collider, ultralow ${\ensuremath{\beta}}^{*}$ optics has been proposed and tuned KEK Accelerator Test Facility 2. In this paper, recent experimental results are presented, which demonstrate capability achieving stabilizing vertical average 60 nm below...
The ATF2 beam line at KEK was built to validate the operating principle of a novel final-focus scheme devised demagnify high-energy beams in future linear lepton colliders; date vertical sizes as small 41 nm have been demonstrated. However, this could only be achieved with an electron bunch intensity $\ensuremath{\sim}10%$ nominal, and it has found that wakefield effects limit size for charges approaching design value ${10}^{10}{e}^{\ensuremath{-}}$. We present studies impact wakefields on...
Abstract Very High Energy Electrons (VHEEs) are a promising alternative to conventional radiotherapy due their highly penetratingnature and applicability as modality for FLASH (ultra-high dose rate) radiotherapy. The distributions VHEE need be optimised; one option is through the use of quadrupole magnets focus beam, reducing healthy tissue allowing targeted delivery at or rates. This paper presents first area focused in air water phantom, obtained using six quadrupoles fixed field strengths...