A5000383893- Plant biochemistry and biosynthesis
- Traditional Chinese Medicine Analysis
- Genomics and Phylogenetic Studies
- Phytochemistry and biological activity of medicinal plants
- Herbal Medicine Research Studies
- thermodynamics and calorimetric analyses
- Insect and Pesticide Research
- Biological and pharmacological studies of plants
- Microbial Natural Products and Biosynthesis
- Pharmacological Effects of Natural Compounds
- Spectroscopy and Chemometric Analyses
- Parkinson's Disease Mechanisms and Treatments
- Ethics in medical practice
- Metabolomics and Mass Spectrometry Studies
- Plant Pathogens and Fungal Diseases
- Toxin Mechanisms and Immunotoxins
- Nuclear Receptors and Signaling
- Ginseng Biological Effects and Applications
- Genetic Neurodegenerative Diseases
- Plant and Fungal Species Descriptions
- Malaria Research and Control
- Plant and Fungal Interactions Research
- Plant Molecular Biology Research
- Advances in Cucurbitaceae Research
- Powdery Mildew Fungal Diseases
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
China Academy of Chinese Medical Sciences
2019-2025
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Shanghai Jiao Tong University
1992-2023
Shandong University of Traditional Chinese Medicine
2022
Guangdong Provincial Hospital of Traditional Chinese Medicine
2022
Guangzhou University of Chinese Medicine
2022
Chengdu University of Traditional Chinese Medicine
2016-2022
Dali University
2022
Wuhan University of Technology
2020
A comprehensive, unbiased inventory of synuclein forms present in Lewy bodies from patients with dementia was carried out using two-dimensional immunoblot analysis, novel sandwich enzyme-linked immunosorbent assays modification-specific antibodies, and mass spectroscopy. The predominant modification α-synuclein is a single phosphorylation at Ser-129. In addition, there set characteristic modifications that are to lesser extent, including ubiquitination Lys residues 12, 21, 23 specific...
The complete chloroplast genome of Artemisia annua (Asteraceae), the primary source artemisinin, was sequenced and analyzed. A. cp is 150,995 bp, harbors a pair inverted repeat regions (IRa IRb), 24,850 bp each that separate large (LSC, 82,988 bp) small (SSC, 18,267 single-copy regions. Our annotation revealed contains 113 genes 18 duplicated genes. gene order in SSC region inverted; this fact consistent with sequences genomes from three other species. Fifteen (15) forward seventeen (17)...
Abstract Background The RUNX1 transcription factor gene is frequently mutated in sporadic myeloid and lymphoid leukemia through translocation, point mutation or amplification. It also responsible for a familial platelet disorder with predisposition to acute (FPD-AML). disruption of the largely unknown biological pathways controlled by likely be development leukemia. We have used multiple microarray platforms bioinformatic techniques help identify these aid understanding why mutations lead...
Paeonia ostii, a common oil-tree peony, is important ornamentally and medicinally. However, there are few studies on the chloroplast genome of ostii. We sequenced analyzed complete P. The size ostii 152,153 bp, including large single-copy region (85,373 bp), small (17,054 pair inverted repeats regions (24,863 bp). encodes 111 genes, 77 protein-coding four ribosomal RNA 30 transfer genes. contains forward (22), palindromic (28), tandem (24). presence rich simple-sequence repeat loci in...
Herbgenomics is an emerging field of traditional Chinese medicine (TCM) research and development. By combining TCM with genomics, herbgenomics can help to establish the scientific validity bring it into wider usage within medicine. Salvia Linn. ( S . Linn.) a large genus Labiatae that includes important medicinal plants. In this study, complete chloroplast (cp) genomes two spp.—namely, S. przewalskii bulleyana , which are used as surrogate for miltiorrhiza —were sequenced compared those...
We sequenced and analyzed the complete chloroplast genome of Aster tataricus (family Asteraceae), a Chinese herb used medicinally to relieve coughs reduce sputum. The A. was 152,992 bp in size, harbored pair inverted repeat regions (IRa IRb, each 24,850 bp) divided into large single-copy (LSC, 84,698 small (SSC, 18,250 region. Our annotation revealed that contained 115 genes, including 81 protein-coding 4 ribosomal RNA 30 transfer genes. In addition, 70 simple sequence repeats (SSRs) were...
<title>Abstract</title> <italic>Nothapodytes nimmoniana</italic> is known to produce the highest content of anticancer compound camptothecin (CPT) in plant kingdom. We present chromosome-level allotetraploid genome <italic>N. nimmoniana</italic>, marking first sequence from order Icacinales. This 5-Gb encodes 92,630 genes, with subgenome B exhibiting dominant gene expression. Through mining, we identified and characterized four key enzymes involved CPT biosynthesis, revealing that shares a...
Abstract In this study, the chloroplast genome sequencing of Achyranthes longifolia , bidentata and aspera were performed by Next-generation technology. The results revealed that there a length 151,520 bp ( A. ), 151,284 151,486 respectively . These have highly conserved structure with pair inverted repeat (IR) regions (25,150 bp; 25,145 25,150 bp), large single copy (LSC) (83,732 83,933 83,966 bp) small (SSC) (17,252 17,263 17,254 in bidentate, There 127 genes annotated, which including 8...
Camptotheca acuminata Decne., the main source of camptothecin (CPT), has received increasing attention for its remarkable antitumor activity. Many CPT derivatives are clinically used as effective anticancer agents worldwide. However, their biosynthesis mechanism remains unclear, and uncovering this pathway would greatly facilitate development alternative production methods to replace current inefficient plant-derived ones. The expression >30,000 genes was accurately quantified using unique...
Artemisinin-based combination therapy has become the preferred approach for treating malaria and successfully reduced malaria-related mortality. Currently, main source of artemisinin is Artemisia annua L., thus, it strategic importance to enhance contents in A. plants. Phytohormones illumination are known be important external environmental factor that can have notable effects on production secondary metabolite. The activities different hormones influenced varying degrees by light, thus...
Lipoxygenase (LOX) is a ubiquitous oxygenase found in animals and plants plays pivotal role diverse biological processes, including defense development. Artemisinin, which can only be obtained from Artemisia annua L., the most effective therapeutic drug for malaria without serious side effects. This study identified analyzed LOX gene family members A. genome at chromosomal level. Twenty genes with various molecular weights, isoelectric points, amino acid numbers were named AaLOX, located...
The roots of Salvia miltiorrhiza Bunge. are commonly used in the treatment cardiovascular diseases, and tanshinones salvianolic acids its main active ingredients. However, composition content ingredients S. planted different regions soil environment also quite different, which adds new difficulties to large-scale standardization artificial cultivation. Therefore, this study, we measured contents rhizosphere elements from 25 production areas eight provinces China, data develop a prediction...
Abstract Background Amorpha-4,11-diene synthase (ADS) is a key enzyme in the artemisinin biosynthetic pathway. ADS promotes first step of synthesis by cyclizing faresyl pyrophosphate to synthesize sesquiterpene product amorpha-4,11-diene. Thanks continuous improvement genomic information, its evolutionary trace can be analyzed genome view. Methods Phylogenetic analysis was used identify -like genes other Asteraceae. Gene structure and motif analyze structural similarity these identified...
Two new alkaloids, 6-(hydroxymethyl)-3,9-dimethyl-7H-benzo[de]quinolin-7-one (1) and 6-(hydroxymethyl)-8-methoxy-3,9-dimethyl-7H-benzo[de]quinolin-7-one (2), together with four known alkaloids (3-6) were isolated from the seeds of Cassia alata.Their structures determined by means HRESIMS extensive 1D 2D NMR spectroscopic studies.Compounds 1-6were tested for their anti-tobacco mosaic virus (TMV) activities, results showed that compound 2 exhibited high anti-TMV activity inhibition rates...
Based on the gradual transformation from wild growth to artificial cultivation, accurate authentication of licorice seeds contributes first committed step its quality control and is pivotal ensure clinical efficacy licorice. However, it still challenging obtain genetically stable germplasm resources due multi-source, multi-heterozygous, polyploid, hybrid characteristics seeds. Here, a new method for determining heterozygosity seed mixture, based various sites, finding composition...
Three new furan-2-carboxylic acids, 5-(4-hydroxy-2-methoxy-6-methyl-phenyl)-3-methylfuran-2-carboxylic acid (1), methyl 5-(4-hydroxy-2-methoxy-6-methylphenyl)-3-methylfuran-2-carboxylate (2), and 5-(3-hydroxy-4-methoxy-5-methylphenyl)-3-methylfuran-2-carboxylic (3), together with two known acids (4 5) were isolated from the leaves of Nicotiana tabacum.Their structures determined by means HRESIMS extensive 1D 2D NMR spectroscopic studies.Compounds 1-5 tested for their anti-TMV activities.The...
Rhododendron is well-known for its beauty and colourful corolla. Although some high-quality whole-genome sequencing of it has been completed, there are few studies on long terminal repeat (LTR) retrotransposons in Rhododendron, which limits our ability to elucidate the causes genetic variations species. Properties intact LTR were investigated at a genome-wide level. Based available data, genomes from five species, i.e. R. griersonianum, simsii, henanense subsp. lingbaoense, mucronatum var....
Abstract Polystyrene/montmorillonite nanocomposites were prepared by γ‐ray radiation polymerization. X‐ray diffraction and high‐resolution transmission electron microscopy confirmed that polystyrene (PS) could be easily inserted between the sheets of montmorillonite (MMT) to form intercalated nanocomposites. In these PS/MMT nanocomposites, distance MMT was barely influenced varying content MMT. Thermal stabilities samples studied thermal gravimetric analysis differential scanning...