A5101539908- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Musculoskeletal pain and rehabilitation
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Bone Tumor Diagnosis and Treatments
- Kruppel-like factors research
- Prostate Cancer Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Polymer Surface Interaction Studies
- Knee injuries and reconstruction techniques
- Urinary Bladder and Prostate Research
- Hematopoietic Stem Cell Transplantation
- Urologic and reproductive health conditions
- Lung Cancer Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Genomics and Rare Diseases
- Endometrial and Cervical Cancer Treatments
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
Wellcome Sanger Institute
2020-2025
Wellcome/MRC Cambridge Stem Cell Institute
2020-2025
University of Cambridge
2020-2025
National University Hospital
2020-2022
Singapore General Hospital
2020
Guy's and St Thomas' NHS Foundation Trust
2017
University Hospital of Bern
2017
University College London
2015
University of California, Irvine
2010-2012
Mercy Hospital for Women
2009
Ewing sarcoma is a high-grade malignancy that most often occurs in children. Because its occurrence adults has been historically low, few studies have published on the epidemiology of this group patients. By using data from large, population-based cancer registry, authors designed present study to examine outcome children and adult patients with relevant prognostic factors.A retrospective analysis patient cases California Cancer Registry database was performed identify incident diagnosed...
ABSTRACT Mutations in cancer-associated genes drive tumour outgrowth. However, the timing of driver mutations and dynamics clonal expansion that lead to human cancers are largely unknown. We used 448,553 somatic from whole-genome sequencing 843 haematopoietic colonies reconstruct phylogeny haematopoiesis, embryogenesis clinical disease, 10 patients with myeloproliferative neoplasms which blood more common older age. JAK2 V617F , pathognomonic mutation these cancers, was acquired utero or...
Different intrinsic properties of the constituent cells anterior cruciate ligament (ACL) and medial collateral (MCL) have been proposed to be one factors in differential repair mechanisms. We found that outgrowth from rabbit ACL explants was slower than MCL after 10 d. Growth curves cultures at both Passage numbers 2 6 showed a rate proliferation (P < 0.005). The proliferative response b-FGF TGF-beta also investigated. Both had no significant effect on cell 48 h. However, did an inhibitory...
Abstract Ageing is the decline in an organism's function over time, driven by internal and external stresses. Key features of ageing include genomic instability, telomere shortening, epigenetic changes, loss proteostasis, they tend to worsen compound with age. However, how do these molecular changes manifest observed systemic seen unclear. Somatic mutations contribute cancer but are thought have a limited role ageing, as genome tolerates rare random errors. Yet, some confer fitness advantage...
Abstract Mutation of some genes drives uncontrolled cell proliferation and cancer. The Philadelphia chromosome in chronic myeloid leukaemia (CML) provided the very first such genetic link to cancer 1,2 . However, little is known about trajectory CML, rate BCR::ABL1 clonal expansion how this affects disease. Using whole-genome sequencing 1,013 haematopoietic colonies from nine patients with CML aged 22 81 years, we reconstruct phylogenetic trees haematopoiesis. Intronic breaks BCR ABL1 were...
Abstract As we age, cells accumulate somatic mutations, undergo epigenetic alterations, and experience telomere shortening. In older individuals, normal tissues are often overtaken by expanding clones of that have acquired mutations promoting proliferation. Whether changes can also provide selective advantage induce clonal expansion in ageing is less clear. Here, sequenced 719 whole genomes methylomes single-cell colonies derived from HSCs three healthy individuals breast cancer patients....
Abstract Cellular migration and proliferation are integral aspects of wound healing. An in vitro assay for cellular using explants rabbit anterior cruciate medial collateral ligaments was developed previously. This study presents the effects serum‐free culture medium supplemented with basic fibroblast growth factor, bovine insulin, transforming factor‐β1, platelet‐derived factor‐B, added either individually or combination, on cell outgrowth ligaments. Outgrowth assessed at 3 6 days by...
No AccessJournal of UrologyAdult Urology1 Jul 2009Risk Factors for Trocar Injury to the Bladder During Mid Urethral Sling Procedures Kobi Stav, Peter L. Dwyer, Anna Rosamilia, Lore Schierlitz, Yik N. Lim, and Joe Lee StavKobi Stav Department Urogynaecology, Mercy Hospital Women, Melbourne, Victoria, Australia Urology, Assaf Harofeh Medical Centre, Zeriffin, Israel , DwyerPeter Dwyer RosamiliaAnna Rosamilia Monash SchierlitzLore Schierlitz LimYik Lim LeeJoe View All Author...
Chordoma is the most common primary malignant tumor of spine. It extremely rare and has been studied primarily in single-institution case series. Using data from a large, population-based cancer registry, we designed present study to examine outcome for patients with chordoma determine relevant prognostic factors.A retrospective analysis California Cancer Registry database was performed identify diagnosis years 1989 2007. Comparisons examined differences demographics, disease...
In Brief Study Design. An in vitro biomechanical study of different pedicle screw configuration usage on the thoracic spine using a cadaveric model. Objectives. To investigate degree motion afforded configurations model with 2 degrees intrinsic stability. Summary Background Data. Recently, screws have become an alternative to hook and wire fixation, gained popularity. Clinically, use has ranged from application every segment, skipping other level. There exists no clear consensus as which...
In multiple myeloma (MM), del(17p) is associated with a poor outcome if present in greater than half the tumour cells. Similarly, intracranial involvement, often seen context of advanced disease, also heralds short survival. We rare case MM presenting disease and carrying 100% This patient was successfully treated combination chemotherapy employing central nervous system directed agents bortezomib, followed by autologous stem cell transplant consolidation radiotherapy, bortezomib...
Abstract Cancer is the proliferation of a genetic clone at expense its neighbours and normal tissue function. Studies have shown that with ageing, tissues become colonised by expanding clones, which acquired fitness-enhancing mutations allow them to over-proliferate relative their neighbours. However, whether clones’ founding cell also carries an epigenome inherited incompletely understood. In following study, we performed multi-omic profiling human hematopoietic stem cells (HSCs) establish...
Haemoglobin Baden is a rare variant haemoglobin which has only recently been clinically and functionally characterised. We present the case of young adult male patient who presented with an erythrocytosis but was asymptomatic. His mother also diagnosed retrospectively having being treated regular venesections. discuss management plan potential significance carrier this variant.