A5056978527- Parasites and Host Interactions
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Travel-related health issues
- Trypanosoma species research and implications
- Global Maternal and Child Health
- Parasite Biology and Host Interactions
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Legionella and Acanthamoeba research
- Helminth infection and control
- Pneumonia and Respiratory Infections
- Parasitic Infections and Diagnostics
- Vibrio bacteria research studies
- COVID-19 Clinical Research Studies
- Parasitic infections in humans and animals
- Tuberculosis Research and Epidemiology
- Global Health Workforce Issues
- Autoimmune and Inflammatory Disorders Research
- Zoonotic diseases and public health
- COVID-19 epidemiological studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Mollusks and Parasites Studies
- Vector-borne infectious diseases
- Parasitic Diseases Research and Treatment
Hospital Universitari Germans Trias i Pujol
2016-2025
Institut Català de la Salut
2016-2025
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2022-2025
Badalona Serveis Assistencials
2022-2024
Universitat Autònoma de Barcelona
2015-2024
Fundació Lluita contra les Infeccions
2020-2024
Fundació ACE
2024
Universidad del Norte
2023
Instituto de Salud Carlos III
2022
Centro de Investigación Biomédica en Red
2022
Current therapeutic options for Chagas' disease are limited to benznidazole and nifurtimox, which have been associated with low cure rates in the chronic stage of considerable toxicity. Posaconazole has shown trypanocidal activity murine models.We performed a prospective, randomized clinical trial assess efficacy safety posaconazole as compared adults Trypanosoma cruzi infection. We randomly assigned patients receive at dose 400 mg twice daily (high-dose posaconazole), 100 (low-dose or 150...
BackgroundThe nematode Strongyloides stercoralis has a very particular autoinfection life-cycle which leads to chronic infections remaining undetected for decades. However, hyperinfection can occur in patients receiving immunotherapy resulting high mortality rates. The main objective of this study was assess the results 10-year multicenter surveillance program performed an area with dense immigration Barcelona, Spain.
Background Sub-Saharan African migrants may be suffering from imported Schistosomiasis, which can evolve into chronic schistosomiasis. Positive response to empiric treatment with praziquantel indicate the presence of persistent infection. Methods We tested in a cohort sub-Saharan probable Tests were administered at baseline and 6 12 months. Results Among 187 eligible participants 149 completed follow-up. Of these 119 (79.9%) males 65 (43.6%) Senegal. Median age was 43 years (IQR 35-51)...
Background Amoebic colitis is the most frequent clinical manifestation of invasive intestinal infection due to Entamoeba histolytica and a common cause diarrhoea worldwide. Since higher transmission rates are usually related poor health exposure unhygienic conditions, cases reported in Europe involve immigrants international travellers. The goal this study was characterise both epidemiological features European population diagnosed with amoebic then evaluate diagnostic tools therapeutic...
Background Chagas disease (CD) is a major cause of cardiomyopathy in Latin America, and migration movements have now spread the worldwide. However, data regarding (CC) usefulness echocardiography non endemic countries are still scarce. Methods results We selected 485 patients chronic phase CD from two Spanish settings. Data physical examination, electrocardiogram (EKG), x-ray, dimensional transthoracic echocardiogram were recorded. Trypanosoma cruzi DNA was assessed by PCR peripheral blood....
Abstract We performed a prospective, cross-sectional study of household contacts symptomatic index case-patients with SARS-CoV-2 infection during the shift from Delta- to Omicron-dominant variants in Spain. included 466 227 cases. The secondary attack rate was 58.2% (95% CI 49.1%–62.6%) Delta-dominant period and 80.9% 75.0%–86.9%) period. During period, unvaccinated had higher probability than vaccinated (odds ratio 5.42, 95% 1.6–18.6), but this effect disappeared at ≈20 weeks after...
Abstract Background Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imported to Europe. Male urogenital manifestations are often neglected. We aimed ascertain the prevalence of genitourinary clinical signs symptoms among long-term African migrants a non-endemic European country using serology test. Methods carried out prospective, community-based cross-sectional study adult male from living Spain. Schistosoma tests microscopic urine examinations were out, data obtained...
The involvement of genital women tract chronic schistosomiasis among African migrant in non-endemic countries might be more prevalent than expected. A gold standard diagnostic is most needed to determine the true prevalence this condition and characterize clinical presentation female particular population.
Background Schistosomiasis, one of the neglected tropical diseases (NTD) listed by WHO, is an acute and chronic parasitic disease caused blood flukes (trematode worms) genus Schistosoma. Complications long-term infestation include liver cirrhosis, bladder tumors kidney failure. The objective this study was to carry out a clinical epidemiological characterization schistosomiasis-diagnosed immigrant population with residencein EU as well evaluate diagnostic methods available date. Methods...
Introduction Strongyloides stercoralis is a globally distributed nematode that causes diverse clinical symptoms in humans. Spain, once considered an endemic country, has experienced recent increase imported cases. The introduction of serology helps diagnosis and currently replacing microbiological techniques some settings, but its sensitivity variable can be low immunocompromised patients. Diagnosis only confirmed by identification larvae. Often, this "gold standard" achieved severe cases,...
Background Disseminated tuberculosis is frequently associated with delayed diagnosis and a poorer prognosis. Objectives To describe case series of disseminated TB delay in low burden country during the COVID-19 period. Methodology We consecutively included all patients reported from 2019 to 2021 reference hospital Northern Crown Metropolitan Area Barcelona. collected socio-demographic information, clinical, laboratory radiological findings. Results 30 study period—5, 9, 16 2019, 2020,...
Abstract Purpose This study investigates the potential of inflammatory parameters (IP), symptoms, and patient-related outcome measurements as biomarkers severity their ability to predict tuberculosis (TB) evolution. Methods People with TB were included prospectively in Stage-TB conducted at five clinical sites Barcelona (Spain) between April 2018 December 2021. Data on demographics, epidemiology, features, microbiology, Sanit George Respiratory Questionnaire (SGRQ) Kessler-10 Health-Related...
The Chikungunya virus (CKIKV) is currently present in America. Travel between America and Europe particularly intense one of the main vectors CHIKV, Aedes albopictus, well established Mediterranean basin. We describe a series imported cases that could originate European outbreak.We retrospectively studied CHIKV originating diagnosed last year three Tropical Medicine Units Barcelona International Health Program Catalan Institute (PROSICS). Clinical, microbiological epidemiological data were...
Following Latin American migration, Chagas disease has inevitably appeared in non-endemic countries Europe and elsewhere. New policies are necessary to prevent transmission those but the long, often undetected chronic period of early stages also renders epidemiological studies important. The main objective our study was determine presence clinical, electrocardiogram (ECG) echocardiographic abnormalities a population migrants infected with Trypanosoma cruzi at moment diagnosis. We performed...
To describe the infectious diseases imported by immigrants visiting friends and relatives in their countries of origin.We performed a cross-sectional descriptive study all among adult patients between 01/2001-12/2008. The population was classified 3 groups: a) relatives; b) tourists, c) non-travelling immigrants. Diseases were as (a) cosmopolitan or (b) tropical endemic, and, according to severity mild, serious, (c) potentially lethal.A total 761 analyzed. mean age 31.7 (SD: 12.4) years. Of...
Schistosomiasis among migrant populations in Europe is an underdiagnosed infection, yet delayed treatment may have serious long-term consequences. In this study we aimed to characterize the clinical manifestations of Schistosoma infection women, and degree underdiagnosis.We carried out a prospective cross-sectional population living North Metropolitan Barcelona area coming from schistosomiasis-endemic countries. We obtained clinical, laboratory socio-demographic data electronic records, as...
Imported schistosomiasis is an emerging issue in European countries as a result of growing global migration from schistosomiasis-endemic countries, mainly sub-Saharan Africa. Undetected infection may lead to serious long-term complications with associated high cost for public healthcare systems especially among migrants.To evaluate health economics perspective the introduction screening programs non-endemic prevalence migrants.We calculated costs three approaches-presumptive treatment,...
The use of high-dose intravenous immunoglobulins (IVIGs) as immunomodulators for the treatment COVID-19–affected individuals has shown promising results. IVIG reduced inflammation in these patients, who progressively restored respiratory function. However, little is known about how they may modulate immune responses COVID-19 individuals. Here, we have analyzed levels 41 inflammatory biomarkers plasma samples obtained at day 0 (pretreatment initiation), 3, 7, and 14 from five hospitalized...
Imported diseases recorded in the European Union (EU) increasingly involve traveling immigrants returning from visits to their relatives and friends (VFR). Children of these immigrant families can represent a population extreme vulnerability.A randomized cross-sectional study 698 children under age 15 was performed. VFR non-VFR (or tourist) groups were compared.A total individuals analyzed: 354 males (50.7%) 344 females (49.3%), with median (interquartile range) 4 (2-9) years. Of these, 578...