Sofia Sisti
A5042269047- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Neutropenia and Cancer Infections
- Signaling Pathways in Disease
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects of Natural Compounds
- Tuberculosis Research and Epidemiology
- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- Ginger and Zingiberaceae research
- Diet and metabolism studies
- CRISPR and Genetic Engineering
- Inflammatory Biomarkers in Disease Prognosis
- HIV Research and Treatment
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Hematopoietic Stem Cell Transplantation
- Reproductive tract infections research
- Tryptophan and brain disorders
- Animal Virus Infections Studies
- Genomics and Phylogenetic Studies
- Antibiotic Resistance in Bacteria
- Hematological disorders and diagnostics
Vita-Salute San Raffaele University
2021-2024
IRCCS Ospedale San Raffaele
2023-2024
San Raffaele University of Rome
2023-2024
Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role interferons (IFNs) type I (IFN-I) or III (IFN-III) families remains debated. We scrutinized production IFNs along respiratory tract COVID-19 patients and found that high levels IFN-III, to a lesser extent IFN-I, characterize upper airways with viral burden reduced risk severity. Production specific not members denotes mild pathology efficiently drives transcription genes protect...
Abstract Aconitate decarboxylase 1 (ACOD1) is the enzyme synthesizing itaconate, an immuno-regulatory metabolite tuning host-pathogen interactions. Such functions are achieved by affecting metabolic pathways regulating inflammation and microbe survival. However, at whole-body level, roles of itaconate remain largely unresolved. By using multiomics-integrated approaches, here we show that ACOD1 responds to high-fat diet consumption in mice promoting gut microbiota alterations supporting...
Summary The COVID-19 outbreak driven by SARS-CoV-2 has caused more than 2.5 million deaths globally, with the most severe cases characterized over-exuberant production of immune-mediators, nature which is not fully understood. Interferons type I (IFN-I) or III (IFN-III) families are potent antivirals, but their role in remains debated. Our analysis gene and protein expression along respiratory tract shows that IFNs, especially IFN-III, over-represented lower airways patients COVID-19, while...
Abstract While asymptomatic smoldering multiple myeloma (SMM) holds an overall risk of progression to (MM) at 10% per year, only active surveillance is offered most patients affected by SMM, which leaves them in anxiety and frustration. Intestinal microbiota gut-born T helper 17 (Th17) lymphocytes may act as drivers MM evolution. In transgenic Vk*MYC mice developing de novo MM, invariably evolves from Early-MM that mimics SMM full-blown Late-MM, we investigated the impact gut modulation on...
<h3>Background</h3> Poor diet quality lacking plant-based foods, elevated body mass index (BMI), insulin resistance, microbiome dysbiosis, as well inflammation have all been implicated in progression from monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) to MM. Whether a dietary intervention can delay has not investigated. <h3>Methods</h3> We conducted pilot, single-arm trial providing high fiber plant based (HFPBD) for 12 weeks health coaching...
The ongoing emergence of SARS-CoV-2 variants poses significant challenges to existing therapeutics. spike (S) glycoprotein is central both viral entry and cell-to-cell transmission via syncytia formation, a process that confers resistance neutralizing antibodies. mechanisms underlying this resistance, particularly in relation spike-mediated fusion, remain poorly understood.