A5054088124- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Obstructive Sleep Apnea Research
- Pulmonary Hypertension Research and Treatments
- Airway Management and Intubation Techniques
- Sepsis Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- Aortic aneurysm repair treatments
- Infectious Aortic and Vascular Conditions
- Chronic Disease Management Strategies
- Statistical Methods in Clinical Trials
- Glaucoma and retinal disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Language Development and Disorders
- Cardiac Fibrosis and Remodeling
- Pharmaceutical studies and practices
- Cytokine Signaling Pathways and Interactions
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac Imaging and Diagnostics
- Data Analysis with R
- Dysphagia Assessment and Management
University of Cambridge
2019-2024
Papworth Hospital
2018-2024
MRC Biostatistics Unit
2019-2024
Papworth Hospital NHS Foundation Trust
2019-2022
Medical Research Council
2022
Lancaster University
2018
We assessed the simple view of reading as a framework for Grade 3 comprehension in two ways. first confirmed that structural equation model which word recognition, listening comprehension, and were by multiple measures to inform each latent construct provided an adequate fit this 3. next examined how well prekindergarten (pre-K) oral language (vocabulary, grammar, discourse) code-related (letter print knowledge, phonological processing) skills predicted through core components view:...
Abstract Aims In pre-clinical models of acute myocardial infarction (MI), mature B cells mobilize inflammatory monocytes into the heart, leading to increased infarct size and deterioration cardiac function, whilst anti-CD20 antibody-mediated depletion limits injury improves function. Rituximab is a monoclonal antibody targeted against human cells. However, its use in cardiovascular disease untested currently contraindicated. Therefore, we assessed safety, feasibility, pharmacodynamic effect...
Summary NHS England recently mandated that the National Early Warning Score of vital signs be used in all acute hospital trusts UK despite limited validation postoperative setting. We undertook a multicentre study 13,631 patients discharged from intensive care after risk‐stratified cardiac surgery four centres, which Vital PAC TM to electronically collect signs. analysed 540,127 sets generate logistic score, discrimination we compared with national additive score for composite outcome of:...
Population heterogeneity is frequently observed among patients' treatment responses in clinical trials because of various factors such as background, environmental, and genetic factors. Different subpopulations defined by those baseline can lead to differences the benefit or safety profile a therapeutic intervention. Ignoring between substantially impact on medical practice. One approach address necessitates designs analysis with subpopulation selection. Several types have been proposed for...
International early warning scores (EWS) including the additive National Early Warning Score (NEWS) and logistic EWS currently utilise physiological snapshots to predict clinical deterioration. We hypothesised that a dynamic score vital sign trajectory would improve discriminatory power.Multicentre retrospective analysis of electronic health record data from postoperative patients admitted cardiac surgical wards in four UK hospitals. Least absolute shrinkage selection operator-type...
Précis: In this study, we found a high prevalence of obstructive sleep apnea (OSA) among patients with primary open-angle glaucoma (POAG) but was not different (nor OSA more severe) to matched people without glaucoma. Rationale: It has been proposed that might be contributing factor in the development POAG and by extension there could role for screening OSA. Objectives: To assess whether is from examine associations between apnea-hypopnea index (AHI) markers functional structural changes...
Abstract Background High-flow nasal therapy is a non-invasive form of respiratory support that delivers low-level, flow dependent positive airway pressure. The device can be better tolerated by patients than alternatives such as continuous primary objective to determine if prophylactic high-flow after tracheal extubation result in an increase the number days alive and at home within first 90 surgery, when compared with standard oxygen therapy. co-primary estimate incremental...
Abstract OBJECTIVES The Amaze trial showed that adding atrial fibrillation (AF) surgery to cardiac operations increased return sinus rhythm (SR) without impact on quality of life or survival at 2 years. We report outcomes 5 METHODS In a multicentre, phase III, pragmatic, double-blind, randomized controlled superiority trial, patients with >3 months AF were 1:1 adjunct control. Primary 1-year SR restoration and 2-year quality-adjusted already reported. This study reports rhythm,...
Abstract Background The NOTACS trial will assess the efficacy, safety and cost-effectiveness of high-flow nasal therapy (HFNT) compared to standard oxygen (SOT) on outcomes patients after cardiac surgery. Methods/design is an adaptive, international, multicentre, parallel-group, randomised controlled trial, with a pre-planned interim sample size re-estimation (SSR). A minimum 850 be 1:1 receive either HFNT or SOT. primary outcome days alive at home in first 90 planned surgery (DAH90), number...
Abstract Background Repair of thoracic aortic aneurysms with either endovascular repair (TEVAR) or open surgical (OSR) represents major surgery, is costly and associated significant complications. The aim this study was to establish accurate costs delivering TEVAR OSR in a cohort UK NHS patients suitable for treatment the whole pathway from admission discharge 12-month follow-up. Methods A prospective 30 vascular/cardiothoracic units England aged ≥18, distal arch/descending (CTAA)...
Abstract Background Coronary microvascular dysfunction (CMD) after percutaneous coronary intervention (PCI) is prognostically important and may also be a cause of persistent angina. The stent balloon inflation technique or material properties influence the degree CMD post‐PCI. Methods Thirty‐six patients with stable angina attending for elective PCI were randomized to either slow drug eluting (DES) implantation (DES group): +2 atm. every 5 s., maintained further 30 s standard std rapid...
Abstract Background The NOTACS trial will assess the efficacy, safety and cost-effectiveness of high-flow nasal therapy (HFNT) compared to standard oxygen (SOT) on outcomes patients after cardiac surgery. Methods/design is an adaptive, international, multicentre, parallel group, randomised controlled trial, with a pre-planned interim sample size re-estimation (SSR). A minimum 850 be 1:1 receive either HFNT or SOT. primary outcome days alive at home in first 90 planned surgery (DAH90), number...
Introduction Sarcoidosis is a multisystem disease, predominantly affecting the lungs but can involve heart, resulting in cardiac sarcoidosis (CS). Patients require MRI/Positron Emission Tomography (PET) scans for diagnosis. Echocardiography, ECG and Holter monitoring may be indicative not diagnostic alone. present late with conduction defects, heart failure or sudden death. The CASPA (CArdiac PApworth) study protocol aims to (1) use MRI identify CS prevalence; (2) speckle-tracking...
Abstract Background Obstructive sleep apnoea (OSA) involves repeated breathing pauses during due to upper airway obstruction. It causes excessive daytime sleepiness and has other health impacts. Continuous positive pressure (CPAP) therapy is effective first line treatment for moderate severe OSA. Unfortunately, many patients have difficulty tolerating CPAP intolerance probably an important contributing factor. Mandibular advancement devices (MAD) are alternative CPAP. They worn in the mouth...
<h3>Background</h3> Anti-fibrotic (AF) medications and pulmonary rehabilitation (PR) are recommended by international guidelines as treatments for idiopathic fibrosis (IPF). However, the combined effects of both these on exercise capacity lung function is unknown. We aimed to investigate whether patients who utilised experienced an enhanced effect compared those treated with AF only. <h3>Method</h3> With ethical approval, IPF were retrospectively grouped into PR (n=34) alone (n=56). Six...
Abstract • Background : Obstructive Sleep Apnoea (OSA) involves repeated breathing pauses during sleep due to upper airway obstruction. It causes excessive daytime sleepiness and has other health impacts. Continuous Positive Airway Pressure(CPAP) therapy is effective first line treatment for moderate severe OSA. Unfortunately, many patients have difficulty tolerating CPAP pressure intolerance probably an important contributing factor. Mandibular Advancement Devices (MAD) are alternative...