Giovanni Luca Botto

ORCID: 0000-0002-8049-7517
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About
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Research Areas
  • Cardiac pacing and defibrillation studies
  • Cardiac Arrhythmias and Treatments
  • Atrial Fibrillation Management and Outcomes
  • Cardiac electrophysiology and arrhythmias
  • Cardiovascular Function and Risk Factors
  • Gastrointestinal Tumor Research and Treatment
  • Heart Failure Treatment and Management
  • Health Systems, Economic Evaluations, Quality of Life
  • Cardiomyopathy and Myosin Studies
  • Heart Rate Variability and Autonomic Control
  • Metastasis and carcinoma case studies
  • Neurological disorders and treatments
  • Cancer Immunotherapy and Biomarkers
  • Medical Coding and Health Information
  • Cardiac, Anesthesia and Surgical Outcomes
  • Colorectal Cancer Surgical Treatments
  • Cardiovascular and exercise physiology
  • Breast Lesions and Carcinomas
  • Cardiac Structural Anomalies and Repair
  • Neuroscience and Neural Engineering
  • Venous Thromboembolism Diagnosis and Management
  • Acute Ischemic Stroke Management
  • Cardiovascular Effects of Exercise
  • ECG Monitoring and Analysis
  • Mobile Health and mHealth Applications

Aziende Socio Sanitaria Territoriale Rhodense
2018-2025

Carlo Forlanini Hospital
2024

ATS Sardegna (Italy)
2019-2024

Ospedale Sandro Pertini
2023

Ospedale Santa Maria
2023

Presidio Ospedaliero
2023

Azienda Socio Sanitaria Territoriale Lariana
2016-2022

CTO Hospital
2019

Ospedale Sant'Anna
1999-2018

Ospedale Sant'Anna
2016

In-hospital administration of flecainide and propafenone in a single oral loading dose has been shown to be effective superior placebo terminating atrial fibrillation. We evaluated the feasibility safety self-administered fibrillation recent onset outside hospital.We administered either or orally restore sinus rhythm 268 patients with mild heart disease none who came emergency room that was hemodynamically well tolerated. Of these patients, 58 (22 percent) were excluded from study because...

10.1056/nejmoa041233 article EN New England Journal of Medicine 2004-12-01

Asymptomatic atrial fibrillation (AF) can expose patients to the risk of stroke. The primary objective this study was assess incidence thromboembolic events in relationship with CHADS(2) (congestive heart failure, hypertension, age >or=75 years, diabetes mellitus, and prior stroke, or transient ischemic attack) score AF presence/duration. secondary compare intermittent versus continuous monitoring strategies.Data from an implanted pacemaker a history were analyzed. Thromboembolic quantified...

10.1111/j.1540-8167.2008.01320.x article EN Journal of Cardiovascular Electrophysiology 2008-10-31

In patients with atrial fibrillation (AF), stroke risk stratification schema do not consider AF parameters. The aim of the study is to assess impact combining factors continuous burden monitoring.In this retrospective 568 implanted a DDDR-P pacemaker (AT-500; Medtronic) and history were continuously monitored for 1 year.During follow-up, 14 (2.5%) had thromboembolic event. Patients divided into 3 groups: ≤5 minutes per day (AF-free; n=223 [39%]), >5 but <24 hours (AF-5 minutes; n=179 [32%]),...

10.1161/strokeaha.110.609297 article EN Stroke 2011-04-15

Atrial fibrillation (AF) is a common comorbidity in bradycardia patients. Advanced pacemakers feature atrial preventive pacing and antitachycardia (DDDRP) managed ventricular (MVP), which minimizes unnecessary right pacing. We evaluated whether DDDRP MVP might reduce mortality, morbidity, or progression to permanent AF when compared with standard dual-chamber (Control DDDR).In randomized, parallel, single-blind, multi-centre trial we enrolled 1300 patients previous tachyarrhythmias, whom...

10.1093/eurheartj/ehu165 article EN European Heart Journal 2014-04-25

We developed and validated an algorithm for prediction of heart failure (HF) hospitalizations using remote monitoring (RM) data transmitted by implanted defibrillators.The SELENE HF study enrolled 918 patients (median age 69 years, 81% men, median ejection fraction 30%) with cardiac resynchronization therapy (44%), dual-chamber (38%), or single-chamber defibrillators atrial diagnostics (18%). To develop a predictive algorithm, temporal trends diurnal nocturnal rates, ventricular...

10.1093/europace/euab170 article EN cc-by-nc EP Europace 2021-06-18

<h3>AIM</h3> To define the effect of defibrillator paddle position on technical success and dc shock energy requirements external cardioversion atrial fibrillation. <h3>METHODS</h3> 301 patients (mean (SD) age 62 (11) years) with stable fibrillation were randomly assigned to elective using anterolateral (ventricular apex–right infraclavicular area; group AL (151 patients)) or anteroposterior (sternal body–angle left scapula; AP (150 patients)). A step up protocol was used, delivering a 3...

10.1136/hrt.82.6.726 article EN Heart 1999-12-01

Abstract Aims To predict worsening heart failure hospitalizations (WHFHs) in patients with implantable defibrillators and remote monitoring, the HeartInsight algorithm (Biotronik, Berlin, Germany) calculates a (HF) score combining seven physiologic parameters: 24 h rate (HR), nocturnal HR, HR variability, atrial tachyarrhythmia, ventricular extrasystoles, patient activity, thoracic impedance. We compared temporal trends of HF its components 12 weeks before WHFH 12-week without WHFH, to...

10.1093/europace/euae032 article EN cc-by EP Europace 2024-01-29

A previous randomized study demonstrated that the subcutaneous implantable cardioverter defibrillator (S-ICD) was noninferior to transvenous ICD with respect device-related complications and inappropriate shocks. However, performed prior widespread adoption of pulse generator implantation in intermuscular (IM) space instead traditional (SC) pocket. The aim this analysis compare survival from shocks between patients who underwent S-ICD positioned an IM position comparison SC pocket.We...

10.1093/europace/euad028 article EN cc-by-nc EP Europace 2023-02-16

Patients with cardiomyopathies and channelopathies are usually younger have a predominantly arrhythmia-related prognosis; they nearly normal life expectancy thanks to the protection against sudden cardiac death provided by implantable cardioverter defibrillator (ICD). The subcutaneous ICD (S-ICD) is an effective alternative transvenous has evolved over years. This study aimed evaluate rate of inappropriate shocks (IS), appropriate therapies, device-related complications in patients who...

10.1093/europace/euad239 article EN cc-by EP Europace 2023-08-02

In subcutaneous implantable cardioverter defibrillator (S-ICD) recipients, the UNTOUCHED study demonstrated a very low inappropriate shock rate on programming conditional zone between 200 and 250 bpm for arrhythmias >250 bpm. The extent to which this approach is adopted in clinical practice still unknown, as its impact rates of appropriate therapies.We assessed ICD implantation during follow-up cohort 1468 consecutive S-ICD recipients 56 Italian centres. We also measured occurrence shocks...

10.1093/europace/euac234 article EN cc-by-nc EP Europace 2023-03-18

Abstract Background The mechanism of typical slow‐fast atrioventricular nodal re‐entrant tachycardia (AVNRT) and its anatomical electrophysiological circuit inside the right atrium (RA) Koch's Triangle (KT) are not well known. Objective To identify potentials compact AV node inferior extensions to perform accurate mapping RA KT in sinus rhythm (SR) during AVNRT, define circuit. Methods Consecutive patients with AVNRT were enrolled 12 Italian centers underwent ablation by means a basket...

10.1111/jce.16168 article EN Journal of Cardiovascular Electrophysiology 2024-01-07

Abstract Aims Subcutaneous implantable cardioverter–defibrillator (S-ICD) therapy is expanding rapidly. However, there are few data on the S-ICD extraction procedure and subsequent patient management. The aim of this analysis was to describe procedure, management, outcome extractions in clinical practice. Methods results We enrolled consecutive patients who required complete at 66 Italian centres. From 2013 2022, 2718 undergoing de novo implantation an were enrolled. Of these, 71 system (17...

10.1093/europace/euad158 article EN cc-by-nc EP Europace 2023-06-01

Abstract Background The subcutaneous implantable cardioverter-defibrillator (S-ICD) is an alternative to traditional ICDs. PRAETORIAN score, based on chest radiographs, has been validated predict the probability of successful S-ICD defibrillation testing by assessing factors like fat thickness between coil and sternum generator placement. Objective This study evaluated correlation score clinical characteristics, as well implantation variables. Methods We retrospectively analyzed data from...

10.1093/europace/euaf011 article EN cc-by EP Europace 2025-01-21
Pietro Francia Matteo Ziacchi Federico Migliore Paolo De Filippo A Dello Russo and 95 more Stefano Viani Antonio Rapacciuolo Giulio Falasconi Carmen Adduci Giovanni Bisignani Luca Checchi Giuseppe Busacca Luca Santini Carlo Lavalle Valéria Calvi Antonio Curcio Massimo Stefano Silvetti Antonio Pangallo Marco Carbonaro Davide Giorgi Raimondo Pittorru Mariolina Lovecchio Sergio Valsecchi Mauro Biffi Antonio D’Onofrio Antonio Pelliccia Giovanni Luca Botto Fabio Lorenzo Canevese M. Casale Fabrizio Caravati B Schintu Antonella Scalone Gianfranco Tola Alessio Setzu Giuseppe Santarpia Amato Santoro C. Baiocchi SLunghetti R Gentilini Pietro Palmisano Michele Accogli Ennio Pisanò Giulio Milanese P. Pepi Daniele Nicolis Massimo Mariani Michele Pagani Massimo Vincenzo Bonfantino Vincenzo Caccavo M. Grimaldi Grigorios Katsouras GB. Forleo Enrico Chieffo E. Tavarelli R. Brambilla Antonio Pani Massimo Giammaria M.T. Lucciola C. Amellone Carlo Uran Matteo Baroni Paolo Ferrari Cristina Leidi Fabrizio Drago Vincenzo Pazzano Scott J. Russo Romolo Remoli Irma Battipaglia Ilaria Cazzoli Fabio Anselmo Saputo Chiara Devecchi Lorella Barbonaglia Miguel Viscusi Marcello Brignoli Andrea Mattera Stefano Pedretti Alessandro Lupi S. Tommasi Amir Kol Maria Chiara Gatto Alessandro Persi Anna Gonella Guido Rossetti Endrj Menardi Roberta Rossini Pasquale Notarstefano Martina Nesti A. Fraticelli G. Carreras Sonia Donzelli Corrado P. Marini A Tordini Ludovico Lazzari P. Sartori Pietro Rossi Paolo Di Donna Giuseppe Mascia Paolo Capogrosso P Magliano M. Colimodio Simone Sala

BACKGROUND: The safety of subcutaneous implantable cardioverter defibrillator (S-ICD) recipients who lead active lifestyles and engage in recreational sports is unknown. We aimed to evaluate the association between lifestyle occurrence arrhythmia- device-related complications, appropriate inappropriate shocks S-ICD recipients. METHODS: assessed a cohort young-adult (15–65 years) patients, evaluated their physical activity with IPAQ (International Physical Activity Questionnaire), on shocks....

10.1161/circep.124.013365 article EN Circulation Arrhythmia and Electrophysiology 2025-02-24

Heart rhythm (HR) management is rapidly developing as a subspecialty within cardiology and it imperative to promote ensure sufficient homogeneous training qualification among professionals in Europe. This encouraged the European Society of Cardiology, through Rhythm Association (EHRA), organize Core Curriculum for HR specialist following: definition scope speciality (Syllabus), development minimum standards objectives (Curriculum), model certify teaching units (Accreditation), Registry...

10.1093/europace/eup215 article EN EP Europace 2009-08-01

Background— The role of pacing sites and atrial electrophysiology on the progression fibrillation (AF) to permanent form in patients with sinus node dysfunction (SND) has never been investigated. aim study was investigate relationship between efficacy at low interatrial septum (IAS) or right appendage (RAA) prevent persistent/permanent AF SND. Methods Results— Electrophysiology-Guided Pacing Site Selection (EPASS) Study a prospective, controlled, randomized study. Atrial refractoriness,...

10.1161/circep.110.957126 article EN Circulation Arrhythmia and Electrophysiology 2011-09-24

<h3>Objective</h3> To evaluate the 2-year clinical improvement after 9Ablate and Pace9 therapy to identify variables able influence efficacy of this in patients with permanent atrial fibrillation (AF). <h3>Design</h3> Prospective multicentre observational study. <h3>Setting</h3> Cardiology departments 19 general hospitals Italy, Spain Greece. <h3>Patients</h3> 171 drug-refractory severely symptomatic AF considered for AV junction ablation. <h3>Interventions</h3> Patients underwent ablation,...

10.1136/heartjnl-2011-301069 article EN Heart 2011-11-17
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