A5088046239- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Muscle metabolism and nutrition
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Fatty Acid Research and Health
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Spectroscopy and Chemometric Analyses
- Molecular Sensors and Ion Detection
- Gestational Diabetes Research and Management
- Oxidative Organic Chemistry Reactions
- Advanced Chemical Sensor Technologies
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Phenothiazines and Benzothiazines Synthesis and Activities
- Lipoproteins and Cardiovascular Health
- Cancer-related molecular mechanisms research
- Lipid metabolism and biosynthesis
- Sensory Analysis and Statistical Methods
- Synthesis and pharmacology of benzodiazepine derivatives
- Neural and Behavioral Psychology Studies
Umeå University
2016-2025
University Hospital of Umeå
2016-2024
Umeå Plant Science Centre
2009
Uppsala University
2009
Swedish University of Agricultural Sciences
2009
Abstract Aims APOC3, ANGPTL3, and ANGPTL4 are circulating proteins that actively pursued as pharmacological targets to treat dyslipidaemia reduce the risk of atherosclerotic cardiovascular disease. Here, we used human genetic data compare predicted therapeutic adverse effects inactivation. Methods results We conducted drug-target Mendelian randomization analyses using variants in proximity genes associated with protein levels drug targets. obtained exposure outcome from large-scale...
We have investigated whether postexercise ingestion of carbohydrates in combination with proteins generates a different systemic metabolic response, as compared to the sole carbohydrate or water, early recovery phase following exercise. In addition, patterns related fitness level were studied together individual responses nutritional modulation. Twenty-four male subjects exposed 90 min ergometer-cycling. Each participant was subject four identical test-sessions, including one beverages...
Analytical drift is a major source of bias in mass spectrometry based metabolomics confounding interpretation and biomarker detection. So far, standard protocols for sample data analysis have not been able to fully resolve this. We present combined approach minimizing the influence analytical on multivariate comparisons matched or dependent samples studies. The building randomization procedure run order, constrained independent randomizations between within pairs (e.g. pre/post...
We sought to determine putative relationships among improved mitochondrial respiration, insulin sensitivity and altered skeletal muscle lipids metabolite signature in response combined aerobic resistance training women with obesity.
The dietary inflammatory index (DII®), a validated tool used to measure the potential of diet, has been associated with metabolic disorders in various settings, but not African populations. aim this study was investigate whether DII is markers type 2 diabetes (T2D) risk, and if association mediated by adiposity and/or low-grade inflammation, black South Africa women. Energy-adjusted-DII (E-DII) scores were calculated 190 women (median age, 53 years) from Birth-to-Twenty plus cohort using...
Abstract Aims To investigate the association between dietary patterns at ages 40, 50 and 60 subclinical carotid atherosclerosis age 60. Methods Participants that were years of Swedish VIPVIZA (VisualiZation asymptomatic Atherosclerotic disease) trial baseline (2013-2016) with retrospective VIP (Västerbotten Intervention Programme) data 50, (n=1034) included. Dietary assessed using Mediterranean Diet Score (MDS) Healthy (HDS), while ultrasound was used to measure artery intima-media thickness...
An excessive energy intake combined with a low level of physical activity induces detrimental processes involved in disease development, e.g. type 2 diabetes and cardiovascular disease. However the underlying mechanisms for regulation metabolic capacity fitness status remain unclear. Metabolomics involves global studies reactions an organism or cell. Thus hypotheses regarding biochemical events can be generated to increase understanding development thereby aid novel treatments preventions....
Objective To investigate how weight loss by different diets impacts postprandial levels of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon. Methods In this single-centre, parallel group 2-year trial, 70 healthy postmenopausal obese women were randomised to the Paleolithic diet or a control based on Nordic Nutrition Recommendations. Both without calorie restriction. The primary outcome was change in fat mass. Here, secondary analyses GLP-1, GIP...
Increased levels of branched-chain amino acids (BCAAs) are associated with type 2 diabetes pathogenesis. However, most metabolomic studies limited to an analysis plasma metabolites under fasting conditions, rather than the dynamic shift in response a metabolic challenge. Moreover, profiles peripheral tissues involved glucose homeostasis scarce and transcriptomic regulation genes BCAA catabolism is partially unknown. This study aimed identify differences circulating skeletal muscle OGTT...
Angiopoietin-like proteins, ANGPTL3, ANGPTL4, and ANGPTL8, are involved in regulating plasma lipids. In vitro animal-based studies point to LPL endothelial lipase (EL, LIPG) as key targets of ANGPTLs. To examine the ANGPTL mechanisms for lipid modulation humans, we pursued a genetic mimicry analysis enhancing or suppressing variants LPL, LIPG, C hepatic type (LIPC), ANGPTL8 genes using data on 248 metabolic parameters derived from over 110,000 nonfasted individuals UK Biobank validated...
The gut microbiome interacts with the host in metabolic response to diet, and early microbial aberrancies may be linked development of obesity disorders later life. Probiotics have been proposed affect programming blood lipid levels, although studies are lacking infants. Here, we report on profile global following daily feeding probiotics during weaning. A total 179 healthy, term infants were randomised intake cereals ( n 89) or without 90) addition Lactobacillus paracasei ssp. F19 (LF19) 10...
We studied effects of diet-induced postmenopausal weight loss on gene expression and activity proteins involved in lipogenesis lipolysis adipose tissue. Fifty-eight women with overweight (BMI 32.5 ± 5.5) were randomized to eat an ad libitum Paleolithic-type diet (PD) aiming for a high intake protein unsaturated fatty acids or prudent control (CD) 24 months. Anthropometry, plasma adipokines, fat metabolism subcutaneous tissue (SAT) lipoprotein lipase (LPL) mass SAT measured at baseline after...
Abstract Background Cross-sectional studies in South Africa (SA) have shown that black SA women, despite being more insulin resistant, less visceral adipose tissue (VAT) and subcutaneous (SAT) than white women. This study aimed to investigate whether baseline and/or change body fat its distribution predict type 2 diabetes (T2D) risk middle-aged 13 years later. Methods We studied 142 women who are the caregivers of Birth-to-Twenty plus cohort, had normal glucose tolerance (NGT) at baseline....
The pathogenesis of type 2 diabetes (T2D) in black African women is complex and differs from that their white counterparts. However, earlier studies have been cross-sectional provide little insight into the causal pathways. Exercise training consistently used as a model to examine mechanisms underlying insulin resistance risk for T2D.The objective study was changes sensitivity secretion response 12-week exercise intervention obese South (SA) women.A total 45 (body mass index, BMI: 30-40...
Abdominal fat accumulation after menopause is associated with low-grade inflammation and increased risk of metabolic disorders. Effective long-term lifestyle treatment therefore needed.Seventy healthy postmenopausal women (age 60 ± 5.6 years) BMI 32.5 5.5 were randomized to a Paleolithic-type diet (PD) or prudent control (CD) for 24 months. Blood samples biopsies collected at baseline, 6 months, months analyze inflammation-related parameters.Android decreased significantly more in the PD...
The present study explored patterns of circulating metabolites and proteins that can predict future risk for ST-elevation myocardial infarction (STEMI) non-ST-elevation (NSTEMI). We conducted a prospective nested case-control in northern Sweden individuals who developed STEMI (N = 50) NSTEMI within 5 years individually matched controls 100). Fasted plasma samples were subjected to multiplatform mass spectrometry-based metabolomics multiplex protein analyses. Multivariate analyses used...
A 4-week dietary intervention with a starch- and sucrose-restricted diet (SSRD) was conducted in patients irritable bowel syndrome (IBS) to examine the metabolic profile relation nutrient intake gastrointestinal symptoms. IBS were randomized SSRD (n = 69) or control continuing their ordinary food habits 22). Food registered questionnaires IBS-symptoms severity scale (IBS-SSS) visual analog for (VAS-IBS) completed. Metabolomics untargeted analysis performed by gas chromatography mass...
Objectives: To investigate the long-term effects on cognition and brain function after installing treadmill workstations in offices for 13 months. Methods: Eighty healthy overweight or obese office workers aged 40-67 years were individually randomized to an intervention group, receiving a workstation encouraging emails, control continuing work as usual. Effects cognitive function, hippocampal volume, prefrontal cortex (PFC) thickness, circulating brain-derived neurotrophic factor (BDNF)...
Lifestyle interventions with weight loss can improve insulin sensitivity in type 2 diabetes (T2D), but mechanisms are unclear. We explored circulating and skeletal muscle metabolite signatures of altered peripheral (pIS) hepatic (hIS) overweight obese T2D individuals that were randomly assigned a 12-week Paleolithic-type diet (diet-ex, n = 13) or without (diet, supervised exercise. Baseline post-intervention measures included: mass spectrometry-based metabolomics lipidomics plasma; pIS hIS;...
Abstract Multivariate projection methods are unique in being both multivariable by combining many variables into stronger predictive features (latent variables), and multivariate for able to model systematic variation related orthogonal an observed response. Orthogonal partial least squares (OPLS) is a versatile method analysis of correlation, discrimination effect changes. However, currently OPLS not fully using its potential since considered interpretation, resulting univariate...