A5063338779- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Drug-Induced Ocular Toxicity
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Mitochondrial Function and Pathology
- Cerebral Venous Sinus Thrombosis
- IgG4-Related and Inflammatory Diseases
- Ophthalmology and Visual Impairment Studies
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Vasculitis and related conditions
- Ocular Oncology and Treatments
- Cell Adhesion Molecules Research
- Corneal surgery and disorders
- Long-Term Effects of COVID-19
- Functional Brain Connectivity Studies
- Bacterial Infections and Vaccines
- Otitis Media and Relapsing Polychondritis
- Spondyloarthritis Studies and Treatments
- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
Chinese People's Liberation Army
2015-2025
Chinese PLA General Hospital
2016-2025
Tianjin Medical University
2024
Chinese General Hospital College of Nursing and Liberal Arts
2020-2024
People's Liberation Army No. 150 Hospital
2015-2023
University of Warmia and Mazury in Olsztyn
2022
Charité - Universitätsmedizin Berlin
2022
Instituto Politécnico de Lisboa
2022
Universidade Nova de Lisboa
2022
Hospital Posadas
2022
Objective The aim of this study was to compare the efficacy low-dose rituximab (RTX) and immunosuppressants in treating orbital inflammatory pseudotumor (OIP) with intracranial extension, a refractory high-relapse disease. Methods Patients who had been diagnosed OIP extension were systemic corticosteroids retrospectively recruited at Neuro-Ophthalmology Department Chinese People’s Liberation Army General Hospital between December 2018 September 2022. After methylprednisolone pulse therapy,...
Neuromyelitis Optica (NMO) is a neuroimmune disorder primarily driven by autoantibodies against aquaporin 4 (AQP4), known as NMO-IgG. Although the mechanisms underlying NMO-IgG-induced retinopathy are not fully understood, high expression of AQP4 in retinal Müller cells suggests direct interaction that may trigger inflammatory processes retina. Previous studies indicate microglia play critical role mediating immune responses, leading to neuronal dysfunction. NMO-IgG obtained from clinical...
Background/Aims To investigate clinical characteristics and prognosis of paediatric optic neuritis (PON) in patients seropositive for myelin oligodendrocyte glycoprotein antibody (MOG-Ab) China. Methods Children displaying initial onset (ON) were recruited from the Neuro-ophthalmology Department Chinese People’s Liberation Army General Hospital January 2016 to August 2017. They assigned into three groups based on status: MOG-Ab-seropositive ON (MOG-ON), aquaporin-4 antibody-seropositive...
This paper aims to explore the relationship of retinal neuron apoptosis and manganese superoxidase dismutase (MnSOD) at early phase diabetic retinopathy. Sprague-Dawley rats were grouped into normal controls diabetics. Data collected after 4, 8, 12 weeks (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>12</mml:mn></mml:math>). The pathological changes ultrastructure retina, rate neurons by TdT-mediated dUTP nick end label (TUNEL),...
Background/aims To evaluate the status of myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) in chronic relapsing inflammatory optic neuropathy (CRION) and investigate its different clinical characteristics prognosis. Methods Patients diagnosed with CRION were recruited by Neuro-ophthalmology Department Chinese People's Liberation Army General Hospital from December 2015 to April 2017. Based on antibody status, they assigned either MOG-CRION or seronegative-CRION groups. Results A...
Objective Paraneoplastic optic neuropathy (PON) is relatively uncommon, and the visual outcomes prognosis of this disease have not been well documented. The aim study was to investigate clinical features antibody-mediated PON. Methods Clinical data were retrospectively collected from hospitalised patients diagnosed with PON at Neuro-Ophthalmology Department Chinese People’s Liberation Army General Hospital January 2015 June 2017. Results A total seven (four females three males, 13 involved...
To describe different clinical characteristics and prognosis of optic neuritis (ON) in male patients with seropositive aquaporin-4 antibody (AQP4-Ab) or myelin oligodendrocyte glycoprotein (MOG-Ab) China. Males ON were recruited from the Neuro-ophthalmology Department Chinese People's Liberation Army, General Hospital January 2016 to February 2018. They assigned two groups based on antibodies status: MOG-Ab-seropositive (MOG-ON) Ab-seropositive (AQP4-ON). Seventy-six assessed, including 44...
Neuromyelitis optica spectrum disorder (NMOSD), a severe demyelinating disease, is rare among children. Plasma exchange (PE) widely used as salvage therapy for and corticosteroid-unresponsive patients with NMOSD. Presently, there are limited studies on the safety efficacy of PE in children Herein, we report case six NMOSD who received along outcomes adverse events. All (female, age at onset 4 years 9 months–13 2 months) were AQP4-IgG positive standard using COM.TEC Cell Separator. The...
Detecting imminent collisions is essential for survival. Here, we used high-resolution fMRI at 7 Tesla to investigate the role of attention and consciousness detecting collision trajectory in human subcortical pathways. Healthy participants can precisely discriminate from near-miss an approaching object, with pupil size change reflecting sensitivity. Subcortical pathways superior colliculus (SC) ventromedial pulvinar (vmPul) ventral tegmental area (VTA) exhibited collision-sensitive...
To evaluate the value of plasma exchange (PE) for patients with three subtypes demyelinating optic neuritis (ON): aquaporin-4 (AQP4) antibody-positive ON (AQP4-ON), myelin oligodendrocyte glycoprotein (MOG) (MOG-ON), and AQP4 MOG double-antibody-seronegative (D-ON).A single-center prospective study compared logarithm minimum angle resolution (logMAR) best-corrected visual acuity (BCVA) at most severe onset, 1 day before intravenous high-dose methylprednisolone (IVMP) treatment, PE after...
This study aimed to analyse the structural injury of peripapillary retinal nerve fibre layer (pRNFL) and segmented macular layers in optic neuritis (ON) aquaporin4-antibody (AQP4-Ab) seropositivity(AQP4-Ab-positiveON) patients AQP4-Ab seronegativity (AQP4-Ab-negative ON) order evaluate their correlations with best-corrected visual acuity (BCVA) value early diagnosis neuromyelitis optica (NMO).This is a retrospective, cross-sectional control observational study.In total, 213 ON (291 eyes) 50...
Objectives Population-based studies estimating the incidence of neuromyelitis optica spectrum disorders (NMOSDs) in Asia are limited, and relationship between latitude has been scarcely investigated. We aimed to estimate NMOSDs Chinese adults explore their latitude. Design Cohort study based on data from Urban Employee Basic Medical Insurance China. Participants 177 million people were followed 2016 2017 20 provinces. Primary outcome measures The rate was estimated by Poisson distribution...
To show the clinical characteristics, identify magnetic resonance imaging (MRI) and optical coherence tomography (OCT) features, observe visual outcome of methanol-induced optic neuropathy. Clinical data were retrospectively collected from in-patients diagnosed with neuropathy in Neuro-Ophthalmology Department Chinese People's Liberation Army General Hospital January 2016 to 2021. Eight patients included this study. The exposure time was 6-34 h for ingestion, 3-4 months inhalation, more than...
Objective: To study the differences in immunopathogenesis based on chemokine profile neuromyelitis optica patients positive for AQP4 antibodies or MOG antibodies. Patients and methods : We measured 52 cytokines/chemokines using ELISA 59 serum samples, which were divided into three groups according to CBA results: HCs (n=16), AQP4+(n=20) MOG+ (n=23). The regression equation (R2>0.98) of standard curve was calculated concentration corresponding A value. And then sample value sample. Results:...
Purpose To describe the pattern of MRI changes in pregeniculate visual pathway Leber hereditary optic neuropathy (LHON). Method This retrospective observational study enrolled 60 patients with LHON between January 2015 and December 2021. The abnormal features seen were investigated, then correlated causative mitochondrial DNA (mtDNA) mutation, distribution lesions duration vision loss. Result cohort included 48 (80%) males 53 (88%) had bilateral median age onset was 17.0 years (range...
<h3>Objective</h3> To evaluate the clinical features and prognosis of atypical optic neuritis (ON) with seronegative aquaporin-4 (AQP4) antibody in Chinese patients. <h3>Methods</h3> All patients first or relapsing ON were recruited from Neuro-ophthalmology Department People's Liberation Army General Hospital January 2013 to December 2014 assigned one three groups based on diagnosis: ON, typical neuromyelitis optica spectrum disorder (NMOSD)-ON. <h3>Results</h3> A total 173 included cohort....