A5002529270- Glioma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Cancer, Hypoxia, and Metabolism
- Paleopathology and ancient diseases
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- Neuroscience and Neuropharmacology Research
- Thyroid Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Immunotherapy and Immune Responses
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Virus-based gene therapy research
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Receptor Mechanisms and Signaling
University of Pisa
2016-2025
Azienda Ospedaliera Universitaria Pisana
2014-2024
Hospital de Clínicas da Unicamp
2023-2024
Fondazione Pisa
2016-2019
International Flame Research Foundation
2019
Columbia University
2013
Universidade de São Paulo
2013
Universidade de Ribeirão Preto
2013
University of Calabria
2008-2011
Hospital Israelita Albert Einstein
2009
HRPT2 gene mutations are associated with parathyroid carcinomas, and absence of parafibromin immunoreactivity has been suggested as a diagnostic marker malignancy. The aim our study was to extend studies in series benign malignant tumors cross-validate the results immunohistochemistry those analysis.We performed cyclin D1 immunostaining analysis using loss heterozygosity sequencing specimens from 11 patients carcinoma (eleven primary tumors, one skin, four lung metastases), 22 sporadic...
// Rebecca Lamb 1,2,* , Gloria Bonuccelli Béla Ozsvári 1,2 Maria Peiris-Pagès Marco Fiorillo 1,2,3 Duncan L. Smith 4 Generoso Bevilacqua 5,6 Chiara Mazzanti 5 Liam A. McDonnell Antonio Giuseppe Naccarato 6 Maybo Chiu Luke Wynne Ubaldo E. Martinez-Outschoorn 7 Federica Sotgia and Michael P. Lisanti 1 The Breast Cancer Now Research Unit, Institute of Sciences, University Manchester, UK 2 Manchester Centre for Cellular Metabolism (MCCM), 3 Department Pharmacy, Health...
Background and objectives: Cancer stem cells (CSCs) have been implicated in tumor initiation, recurrence, metastatic spread poor survival multiple types, breast cancers included. CSCs selectively overexpress key mitochondrial-related proteins inhibition of mitochondrial function may represent a new potential approach for the eradication CSCs. Because mitochondria evolved from bacteria, many classes FDA-approved antibiotics, including doxycycline, actually target mitochondria. Our clinical...
Abstract Here, we provide evidence that high ATP production by the mitochondrial ATP-synthase is a new therapeutic target for anticancer therapy, especially preventing tumor progression. More specifically, isolated subpopulation of ATP-high cancer cells which are phenotypically aggressive and demonstrate increases in proliferation, stemness, anchorage-independence, cell migration, invasion multi-drug resistance, as well antioxidant capacity. Clinically, these findings have important...
OBJECTIVE—This study was designed to evaluate the histopathology of neuropathic ulcers and whether pressure relief could change such histological patterns. RESEARCH DESIGN AND METHODS—We compared plantar tissue excised from 10 diabetic patients (group A) with those taken comparable lesions glycemic control after 20 days in a total contact cast B). Tissue specimens were blindly examined by two independent pathologists for hyperkeratosis, fibrosis, cutaneous annexes, capillaries, inflammation,...
Metronomic chemotherapy refers to the administration of at low, nontoxic doses on a frequent schedule with no prolonged breaks. The aim study is rationally develop CPT-11 metronomic regimen in preclinical settings colon cancer. In vitro cell proliferation, apoptosis and thrombospondin-1/vascular endothelial growth factor (TSP-1/VEGF) expression analyses were performed (HUVEC, HMVEC-d) colorectal cancer (HT-29, SW620) cells exposed for 144 h concentrations SN-38, active metabolite CPT-11....
// Chiara Maria Mazzanti 1, * , Francesca Lessi Ivana Armogida 2, 7 Katia Zavaglia 2 Sara Franceschi 1 Mohammad Al Hamad 8 Manuela Roncella 3 Matteo Ghilli Antonio Boldrini 4 Paolo Aretini Giovanni Fanelli Ivo Marchetti Cristian Scatena Jacob Hochman 5 Giuseppe Naccarato 6 Generoso Bevilacqua FPS – The Pisa Science Foundation, Pisa, Italy Department of Pathology, University Hospital, Breast Center, Surgery, Neonatology, Cell and Developmental Biology, Institute Life Sciences, Hebrew...
Laser capture microdissection coupled with RNA-seq is a powerful tool to identify genes that are differentially expressed in specific histological tumor subtypes. To better understand the role of single cell populations complex heterogeneity glioblastoma, we paired and NGS technology study intra-tumoral differences into regions cells human GBM FFPE tumors. We here isolated astrocytes, neurons endothelial 6 different contexts: core pseudopalisading perineuronal astrocytes satellitosis, blood...
Glioblastoma (GB) is the most severe form of brain cancer, with a 12-15 month median survival. Surgical resection, temozolomide (TMZ) treatment, and radiotherapy remain primary therapeutic options for GB, no new therapies have been introduced in recent years. This standstill primarily due to preclinical approaches that do not fully respect complexity GB cell biology fail test efficiently anti-cancer treatments. Therefore, better treatment screening are needed. In this study, we developed...
Toxic multinodular goiter, a heterogeneous disease producing hyperthyroidism, is frequently found in iodine-deficient areas. The pathogenesis of this common clinical entity still unclear. aim the present study was to search for activating TSH receptor (TSHr) or Gsα mutations areas toxic functionally autonomous goiters that appeared hyperfunctioning at thyroid scintiscan but did not clearly correspond definite nodules physical ultrasonographic examination. Surgical tissue specimens from nine...
A viral etiology of human breast cancer (HBC) has been postulated for decades since the identification mouse mammary tumor virus (MMTV). The detection MMTV env-like exogenous sequences (MMTVels) in 30% to 40% invasive HBCs increased attention this hypothesis. Looking MMTVels during progression may contribute a better understanding their role HBC. Herein, we analyzed HBC preinvasive lesions presence MMTVels. Samples were obtained by laser microdissection FFPE tissues: 20 usual-type ductal...
// Caterina Chiappetta 1 , Massimiliano Mancini Francesca Lessi 2 Paolo Aretini Veronica De Gregorio Chiara Puggioni Raffaella Carletti Vincenzo Petrozza Prospero Civita Sara Franceschi Antonio G. Naccarato 3 Carlo Della Rocca M. Mazzanti 2, * and Claudio Di Cristofano 1, UOC of Pathology, Department Medical-Surgical Sciences Bio-Technologies, Sapienza University Rome, Latina, Italy Pisa Science Foundation, Pisa, These authors contributed equally to this work Correspondence to: Rocca, email:...
The development of the human central nervous system represents a delicate moment embryogenesis. purpose this study was to analyze expression multiple immunohistochemical markers in stem/progenitor cells cerebral cortex during early phases development. To end, samples from were obtained 4 embryos 11 weeks gestation. Each sample formalin-fixed, paraffin embedded and immunostained with several including GFAP, WT1, Nestin, Vimentin, CD117, S100B, Sox2, PAX2, PAX5, Tβ4, Neurofilament, CD44,...
Myocardial fibrosis (MF) is a deleterious consequence of aortic valve stenosis (AVS). Global longitudinal strain (GLS) novel left ventricular (LV) functional parameter potentially useful to non-invasively estimate MF. MicroRNAs (miRNAs) are non-coding small ribonucleic acids (RNA) modulating genes function, mainly through RNA degradation. miRNA-21 biomarker associated with MF in pressure overload. The aim the present study was find an integrated algorithm for detection using combined...
The tumor microenvironment (TME) plays an essential role in promoting cancer initiation, progression and metastasis. Cancer-associated fibroblasts (CAFs) are a major constituent of the TME, but universal CAFs' markers have not yet been identified. We selected several new biomarkers [p16 α-smooth muscle actin (α-SMA)] to investigate molecular landscape epithelial ovarian (EOC), given unique TME this malignancy. In total, 64 patients with diagnosis EOC who underwent primary debulking surgery...