A5034082251- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Asthma and respiratory diseases
- Inflammatory Myopathies and Dermatomyositis
- Rheumatoid Arthritis Research and Therapies
- Animal Virus Infections Studies
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Viral Infections and Immunology Research
- Eosinophilic Esophagitis
- Monoclonal and Polyclonal Antibodies Research
- Paraquat toxicity studies and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
- Systemic Sclerosis and Related Diseases
- Axon Guidance and Neuronal Signaling
- COVID-19 Clinical Research Studies
- Eosinophilic Disorders and Syndromes
- Heme Oxygenase-1 and Carbon Monoxide
- Chronic Lymphocytic Leukemia Research
Chiba University Hospital
2012-2024
Chiba University
2014-2024
Karolinska Institutet
2024
Kumamoto University
2021-2023
Benaroya Research Institute
2018-2021
Kawasaki Medical School
1986-1993
Mitsui Memorial Hospital
1975-1989
Stat3 signaling is essential for the induction of RORγt and subsequent Th17 cell differentiation. However, downstream targets expression remain largely unknown. We show here that a novel isoform Sox5, named Sox5t, induced in cells Stat3-dependent manner. In vivo, T cell-specific Sox5-deficient mice exhibit impaired differentiation are resistant to experimental autoimmune encephalomyelitis delayed-type hypersensitivity. Retrovirus-mediated Sox5 together with c-Maf induces even Stat3-deficient...
Objective This prospective study aimed to determine whether the comprehensive ultrasonographic assessment of synovial inflammation predicts relapse after discontinuation treatment with a biologic agent in patients rheumatoid arthritis (RA) clinical remission. Methods RA remission (Disease Activity Score 28 joints [DAS28] <2.6) receiving who agreed discontinue were recruited. Patients underwent ultrasound scan on 134 sites 40 and prospectively followed up for 6 months. Physicians evaluated...
Helios+FoxP3+CD4+ (Helios+) Treg cells are believed to be involved in the regulation of various autoimmune diseases; however, regulatory mechanisms underlying development Helios+ remain uncertain. This study was undertaken elucidate Helios expression CD4+ T and its roles transforming growth factor β (TGFβ)-induced cell function.We examined patients with rheumatoid arthritis by DNA microarray analysis before after treatment biologic agents. We also effect interleukin-6 (IL-6) TGFβ on humans...
Abstract The lungs serve as the primary organ for respiration, facilitating vital exchange of gases with bloodstream. Given their perpetual exposure to external particulates and pathogens, they possess intricate protective barriers. Cellular adhesion in is robustly maintained through tight junctions, adherens desmosomes. Furthermore, pulmonary system features a mucociliary clearance mechanism that synthesizes mucus transports it outside. This enriched chemical barriers like antimicrobial...
Objective. This study aimed to determine whether [18F]fluorodeoxyglucose-PET/CT ([18F]FDG-PET/CT) discriminates PM/DM from non-muscular diseases and also FDG uptake in proximal muscles reflects the activity severity of muscular inflammation PM/DM.
Abstract Background Systemic lupus erythematosus (SLE) is heterogeneous in organ involvement and disease severity, presenting a broad clinical phenotype. type I interferon (IFN) activity has been shown to be associated with nephritis, autoantibodies, treated SLE patients; however, these relationships are unknown treatment-naive patients. We aimed determine the relationship of systemic IFN phenotypes, activity, damage accrual patients before after induction maintenance therapy. Methods Forty...
Although several miRNAs have been shown to regulate autoimmune pathogenesis by affecting lymphocyte function, the roles of in SSc remain unclear. Therefore purpose this study was identify that play a role quantitative PCR screening serum miRNAs.Ninety-five were predicted target SSc-related genes [IL-4, TGF-β, CTGF, PDGF-B, PDGF receptor (PDGFR) α/β and COL1A2) silico analyses selected. The expression these sera patients healthy controls measured PCR. Involvement miR-30b, which most strongly...
Abstract Objectives IgG4-related disease (IgG4-RD) is a systemic autoimmune with an unknown etiology, affecting single/multiple organ(s). Pathological findings include the infiltration of IgG4-producing plasma cells, obliterative phlebitis, and storiform fibrosis. Although immunological studies have shed light on dysregulation lymphocytes in IgG4-RD pathogenesis, role non-immune cells remains unclear. This study aimed to investigate demographics characteristics explore potential biomarkers...
Abstract Group 2 innate lymphoid cells (ILC2s) are a subset of lymphocytes that produce type cytokines, including IL-4, IL-5, and IL-13. GATA3 is critical transcription factor for ILC2 development at multiple stages. However, when how induced to the levels required remains unclear. Herein, we identify ILC2-specific GATA3-related tandem super-enhancers (G3SE) induce high in ILC2-committed precursors. G3SE-deficient mice exhibit deficiency bone marrow, lung, liver, small intestine with minimal...
Immune homeostasis in the intestine is tightly controlled by FOXP3+ regulatory T cells (Tregs), defects of which are linked to development chronic conditions, such as inflammatory bowel disease (IBD). As a mechanism immune evasion, several species intestinal parasites boost Treg activity. The parasite Heligmosomoides polygyrus known secrete molecule (Hp-TGM) that mimics ability TGF-β induce FOXP3 expression CD4+ cells. study aimed investigate whether Hp-TGM could human Tregs potential...
The zinc finger protein 36-like 2, ZFP36L2, is a member of small family RNA-binding proteins composed by ZFP36 (also known as tristetraprolin, TTP), ZFP36L1 and ZFP36L2 in humans, with corresponding murine orthologs. These bind to adenine uridine-rich element (ARE) the 3'untranslated region target messenger RNA stimulate degradation. functions an anti-inflammatory modulator models inflammatory diseases down-regulating production cytokines such tumor necrosis factor-α. However, how alter...
Abstract Objectives Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). However, precise mechanisms by which MTX stalls RA progression and alleviates ensuing disease effects remain unknown. The aim present study was to identify novel therapeutic target molecules, expression patterns are affected in patients with RA. Methods CD4 + T cells from 28 treatment-naïve before 3 months after initiation were subjected DNA microarray analyses. levels semaphorin 3G, a...
Methotrexate (MTX) is a standard, first-line therapy for rheumatoid arthritis (RA); however, its precise mechanisms of action other than antifolate activity are largely unknown. We performed DNA microarray analyses CD4+ T cells in patients with RA before and after MTX treatment found that TP63 was the most significantly downregulated gene treatment. TAp63, an isoform TP63, highly expressed human IL-17–producing Th (Th17) suppressed by vitro. Murine TAp63 at high levels lower thymus-derived...
Regulatory T cells (Tregs) are indispensable for the establishment of tolerance self-antigens in animals. The transcriptional regulator Foxp3 is critical Treg development and function, controlling expression genes important Tregs through interactions with binding partners. We previously reported KAP1 as a partner FOXP3 human Tregs, but mechanisms by which affects function were unclear. In this study, we analyzed mice Treg-specific deletion found that they develop spontaneous autoimmune...
Asthma is a widespread airway disorder where GATA3-dependent Type-2 helper T (Th2) cells and group 2 innate lymphoid (ILC2s) play vital roles. Asthma-associated single nucleotide polymorphisms (SNPs) are enriched in region located 926-970 kb downstream from GATA3 the 10p14 (hG900). However, it unknown how hG900 affects pathogenesis of allergic inflammation. To investigate roles asthma-associated enhancer experimental inflammation, we first examined correlation between expression activation...
Objective We have previously shown that expression of the Bcl‐3 gene, a member IκB family, is down‐regulated in CD4+ T cells from patients with rheumatoid arthritis (RA) following tocilizumab therapy. The objective this study was to examine role pathogenesis RA. Methods DNA microarray analysis used compare signal intensity untreated RA and healthy controls. examined roles interleukin‐6 (IL‐6)/STAT‐3 signaling induction Bcl‐3. In addition, we analyzed gene profiles Bcl‐3–transduced by RNA...
Abstract We measured antibody responses in 2,015 healthcare workers who were receiving 2 doses of BNT162b2 mRNA vaccine against SARS-CoV-2. The vast majority (99.9%) had either seroconversion or a substantial increase titer. A multivariate linear regression model identified predictive factors for which may have clinical implications.
In addition to the pivotal roles of mast cells in allergic diseases, recent data suggest that play crucial a variety autoimmune responses. However, their pathogenesis skeletal muscle diseases have not been clarified despite distribution muscle. Therefore, objective this study is determine development diseases.The number affected was examined patients with dermatomyositis (DM) or polymyositis (PM). The susceptibility cell-deficient WBB6F1-Kit(W)/Kit(Wv) mice (W/W(v) mice) murine model...
The effect of aggressive haemoperfusion; i.e. haemoperfusion 10 h or more during the first 24 after ingestion, on clinical course paraquat poisoning was studied. Among 40 patients admitted within 15 ingestion with an SIPP less than 100 (h x μg ml -1 ), 21 received and 19 conventional same period. Survival rates severity between Proudfoof's curve in two groups were compared by log-rank test. Aggressive did not improve outcome but survival rates; that is, number surviving at particulalr points...