A5010647076- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic and phenotypic traits in livestock
- Animal Genetics and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
- Animal Nutrition and Physiology
- RNA Research and Splicing
- MicroRNA in disease regulation
- Circular RNAs in diseases
- SARS-CoV-2 and COVID-19 Research
- Adipose Tissue and Metabolism
- Meat and Animal Product Quality
- Muscle Physiology and Disorders
- Livestock and Poultry Management
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Bacteriophages and microbial interactions
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Animal Virus Infections Studies
- Effects of Environmental Stressors on Livestock
- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- Regulation of Appetite and Obesity
- Metabolomics and Mass Spectrometry Studies
Guangdong Ocean University
2022-2025
South China University of Technology
2019-2023
South China Agricultural University
2013-2021
Agricultural Research Service
2018-2020
Chinese University of Hong Kong
2020
Prince of Wales Hospital
2020
Beltsville Agricultural Research Center
2019
United States Department of Agriculture
2018-2019
UCLA Health
2016
Ministère de l'Agriculture et de la Souveraineté alimentaire
2016
Altered metabolism is a hallmark of cancer and glycolysis one the important factors promoting tumor development. There however still lack molecular characterization comprehensive studies related to in pan-cancer landscape. Here, we applied gene expression signature quantify 9229 tumors across 25 types 7875 human lung single cells verified robustness using defined samples from previous studies. We classified into score-high -low groups, demonstrated their prognostic associations, identified...
Abstract In the past decade, treatments for tumors have made remarkable progress, such as successful clinical application of targeted therapies. Nowadays, therapies are based primarily on detection mutations, and next-generation sequencing (NGS) plays an important role in relevant research. The mutation frequency is a major problem tumor increasing depth widely used method to improve calling performance. Therefore, it necessary evaluate effect different well tools. this study, Strelka2...
The functional annotation of genomes, including chromatin accessibility and modifications, is important for understanding effectively utilizing the increased amount genome sequences reported. However, while such has been well explored in a diverse set tissues cell types human model organisms, relatively little data are available livestock hindering our complex trait variation, domestication, adaptive evolution. Here, we present first complete global landscape regulatory elements cattle...
Heat stress significantly impairs the growth performance of broilers, which causes serious losses to poultry industry every year. Thus, understanding indigenous chicken breeds under such environment is crucial address heat problem. The purpose this study was investigate effects (HS) on production performance, tissue histology, shock response (HSP70, HSP90), and muscle growth-related genes (GHR, IGF-1, IGF-1R) Normal yellow (NYC) Dwarf (DYC). Seventy-two female birds from each strain were...
To further reveal the phylogenetic evolution and molecular characteristics of whole genome severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on a large number genomes provide basis for prevention treatment SARS-CoV-2.Various analysis methods were employed.The estimated ratio rates non-synonymous to synonymous changes (Ka/Ks) SARS-CoV-2 was 1.008 or 1.094 622 3624 nine key specific sites high linkage, four major haplotypes found: H1, H2, H3 H4. The results Ka/Ks, detected...
The Insulin-like growth factor 2 mRNA binding protein (IGF2BP2) gene is closely associated with the diseases, fat deposition, and reproduction traits in animals. Investigations into relationship between IGF2BP2 polymorphism provide valuable breeding information for enhancing productivity economic gains pigeon. In this study, single nucleotide polymorphisms (SNPs) 13 exons 3' untranslated region (3'UTR) of 292 female pigeons Tianxiang 1 strain were detected through Sanger sequencing, their...
Copy number variations (CNVs), which cover many functional genes, are associated with complex diseases, phenotypic diversity and traits that economically important to raising chickens. The sex-determining region Y-box 6 (Sox6) plays a key role in fast-twitch muscle fiber differentiation of zebrafish mice, but it is still unknown whether SOX6 chicken skeletal development. We identified two copy polymorphisms (CNPs) were significantly related different on the genome level chickens by AccuCopy®...
Clostridium perfringens (CP) type A and newly created G strains are the key etiological factors in induction of necrotic enteritis (NE), an important enteric disease that is responsible for annual loss $6 billion worldwide poultry industry. Several CP toxin genes were found to be critical NE pathogenesis chickens, but limited information available on lethal tpeL gene. In this study, 19 isolated from NE-affected chicken farms characterized microbiologically molecularly evaluated their...
Various studies have shown that lysine acetyltransferase 2A (KAT2A), E2F transcription factor 1 (E2F1), and ubiquitin conjugating enzyme E2 C (UBE2C) genes regulated the proliferation migration of tumor cells through regulating cell cycle. However, there is a lack in-depth systematic research on their mechanisms action. This study analyzed The Cancer Genome Atlas (TCGA) to screen potential candidate regulation network KAT2A E2F1 complex in pan-cancer. Quantitative real-time PCR (qRT-PCR)...
Heat stress (HS) poses significant challenges to broiler production, negatively influencing growth performance and meat quality. This study explores the resilience quality of hybrid chickens with dwarf size frizzled feather traits HS. We investigated F1 progeny derived from a crossbreed yellow (DYCs) Yuexi chickens. Following rearing period 12 weeks, we randomly assigned 72 into two distinct environmental conditions: HS group subjected 35 ± 1 °C for 8 h per day, control (CN) maintained at 26...
The skeletal muscle is the major tissue in animals, and its production subject to a complex strict regulation. proliferation differentiation of myoblasts are important factors determining chicken development. Circular RNAs (circRNAs) endogenous that widely present various tissues organisms. Recent studies have shown circRNA plays key roles development muscles. solute carrier (SLC) family functions transport metabolites such as amino acids, glucose, nucleotides, essential nutrients involved...
To explore the regulatory mechanism of abdominal fat deposition in broilers, 100-day-old Sanhuang chickens ( n = 12) were divided into high-fat and low-fat groups, according to ratio size. Total RNA isolated from 12 tissues was used for miRNA mRNA sequencing. Results sequencing revealed that miR-429-3p highly expressed chicken whereas LPIN1 expression downregulated. Further, we determined promoted preadipocyte proliferation differentiation, exerted an opposite effect. Notably, found...
Adult skeletal muscle is primarily divided into fast and slow-type muscles, which have distinct capacities for regeneration, metabolism contractibility. Satellite cells plays an important role in adult muscle. However, the underlying mechanisms of satellite cell myogenesis are poorly understood. We previously found that Sox6 was highly expressed fast-type Therefore, we aimed to validate from different fiber types investigate regulation on myogenesis. First, isolated fast- muscles...
Effective means for early diagnosis are imperative to reduce death rate of non-small cell lung cancer (NSCLC) patients. We aimed find out high-performance serologic markers distinguish early-stage NSCLC patients from benign pulmonary nodule and healthy controls (HC). Cystatin-SN (CST1) is an active cysteine protease inhibitor the CST superfamily, involving in processes inflammation tumorigenesis. This first exploration diagnostic prognostic values serum CST1 NSCLC.We analyzed transcriptome...
Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV) infection. Plasma EBV DNA a validated screening tool for NPC. In screening, there are some individuals who do not have NPC but carry in plasma. Currently it known from if may be any genotypic differences isolates and non-NPC subjects. Also, low concentrations of plasma could pose challenge to such analysis through sequencing.In training dataset comprised sequencing data subjects, we studied the difference...
The upregulated proline rich 11 (PRR11) plays a critical role in cancer progression. relevant biological functions of PRR11 pan-cancer development are not well understood. In the current study, we found that was 19 types compared with normal tissues and high-expressed predictor poor prognosis 10 by bioinformatics. Then showed interfering on three cell lines could greatly inhibit proliferation migration arrest cells to S phase vivo . Based RNA-seq, downregulation expression extremely suppress...
The quality and quantity of animal meat are closely related to the development skeletal muscle, which, in turn, is determined by myogenic cells, including myoblasts muscle satellite cells (SMSCs). Circular RNA, an endogenous RNA derivative formed through specific reverse splicing mRNA precursors, has potential influence binding miRNAs or regulating gene expression involved muscular growth at transcriptional level. Previous high-throughput sequencing circRNA chicken liver tissue revealed a...